ay-23626 and Psoriasis

ay-23626 has been researched along with Psoriasis* in 1 studies

Other Studies

1 other study(ies) available for ay-23626 and Psoriasis

Article	Year
11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds. Journal of medicinal chemistry, 1977, Volume: 20, Issue:4 A series of 8-alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids which embody structural features of 11,12-secoprostaglandins was synthesized and evaluated for their ability to mimic the E series prostaglandins in stimulating cAMP formation in the mouse ovary and in binding to the rat lipocyte prostaglandin receptor. A key member of the series, 8-methylsulfonyl-12-hydroxyheptadecanoic acid, markedly stimulated cAMP formation at reasonable pharmacological concentrations, shows significant affinity for a prostaglandin receptor, and effectively inhibits antigen-induced lymphocyte transformation. In contrast, this compound is not a substrate for 15-hydroxyprostaglandin dehydrogenase, the major prostaglandin-metabolizing enzyme. Topics: Animals; Binding, Competitive; Blood Pressure; Cyclic AMP; Dogs; Female; Gastric Juice; Humans; In Vitro Techniques; Lymphocytes; Mice; Ovary; Prostaglandins E; Prostaglandins, Synthetic; Psoriasis; Receptors, Prostaglandin; Skin; Structure-Activity Relationship	1977

Article

Year

11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds.

Journal of medicinal chemistry, 1977, Volume: 20, Issue:4

A series of 8-alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids which embody structural features of 11,12-secoprostaglandins was synthesized and evaluated for their ability to mimic the E series prostaglandins in stimulating cAMP formation in the mouse ovary and in binding to the rat lipocyte prostaglandin receptor. A key member of the series, 8-methylsulfonyl-12-hydroxyheptadecanoic acid, markedly stimulated cAMP formation at reasonable pharmacological concentrations, shows significant affinity for a prostaglandin receptor, and effectively inhibits antigen-induced lymphocyte transformation. In contrast, this compound is not a substrate for 15-hydroxyprostaglandin dehydrogenase, the major prostaglandin-metabolizing enzyme.

Topics: Animals; Binding, Competitive; Blood Pressure; Cyclic AMP; Dogs; Female; Gastric Juice; Humans; In Vitro Techniques; Lymphocytes; Mice; Ovary; Prostaglandins E; Prostaglandins, Synthetic; Psoriasis; Receptors, Prostaglandin; Skin; Structure-Activity Relationship

1977