avapro has been researched along with Muscle Contraction in 6 studies
Irbesartan: A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.
irbesartan : A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pretreatment with irbesartan inhibited U46619-induced vasoconstriction, and the dose-response curve was shifted to the right in a dose-dependent manner." | 1.31 | Novel angiotensin II AT(1) receptor antagonist irbesartan prevents thromboxane A(2)-induced vasoconstriction in canine coronary arteries and human platelet aggregation. ( Brosnihan, KB; Diz, DI; Ferrario, CM; Fukuhara, M; Li, P, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vongpatanasin, W | 1 |
| Wang, Z | 1 |
| Arbique, D | 1 |
| Arbique, G | 1 |
| Adams-Huet, B | 1 |
| Mitchell, JH | 1 |
| Victor, RG | 1 |
| Thomas, GD | 1 |
| Li, N | 1 |
| Meng, Y | 1 |
| Cheng, YX | 1 |
| Niu, Y | 1 |
| Shen, B | 1 |
| Li, X | 1 |
| Lai, WY | 1 |
| Hakim, A | 1 |
| Stanke-Labesque, F | 1 |
| Hoffmann, P | 1 |
| Sessa, C | 1 |
| Caron, F | 1 |
| Cracowski, JL | 1 |
| Bessard, G | 1 |
| Cazaubon, C | 1 |
| Gougat, J | 1 |
| Bousquet, F | 1 |
| Guiraudou, P | 1 |
| Gayraud, R | 1 |
| Lacour, C | 1 |
| Roccon, A | 1 |
| Galindo, G | 1 |
| Barthelemy, G | 1 |
| Gautret, B | 1 |
| Morsing, P | 1 |
| Adler, G | 1 |
| Brandt-Eliasson, U | 1 |
| Karp, L | 1 |
| Ohlson, K | 1 |
| Renberg, L | 1 |
| Sjöquist, PO | 1 |
| Abrahamsson, T | 1 |
| Li, P | 1 |
| Fukuhara, M | 1 |
| Diz, DI | 1 |
| Ferrario, CM | 1 |
| Brosnihan, KB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mechanisms of Muscle Blood Flow Dysregulation and Exercise Intolerance in Chronic Kidney Disease[NCT02664519] | 32 participants (Actual) | Interventional | 2016-01-31 | Terminated (stopped due to No funding support and not adequate number of subjects are recruited for the study) | |||
| The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension[NCT01996449] | Phase 2 | 14 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
measurement of sympathetic nerve activity by microneurography (intraneural microelectrodes) (NCT01996449)
Timeframe: 8 weeks post treatment initiation
| Intervention | bursts/minute (Mean) |
|---|---|
| Amlodipine | 41 |
| Eplerenone | 43.8 |
measurement of sympathetic nerve activity by microneurography (intraneural microelectrodes) during arm cycling exercise (NCT01996449)
Timeframe: 8 weeks post treatment initiation
| Intervention | bursts/minute (Mean) |
|---|---|
| Amlodipine | 47 |
| Eplerenone | 51 |
6 other studies available for avapro and Muscle Contraction
| Article | Year |
|---|---|
Functional sympatholysis is impaired in hypertensive humans.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Blood Pressure; Electrocardiogra | 2011 |
Functional sympatholysis is impaired in hypertensive humans.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Blood Pressure; Electrocardiogra | 2011 |
Functional sympatholysis is impaired in hypertensive humans.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Blood Pressure; Electrocardiogra | 2011 |
Functional sympatholysis is impaired in hypertensive humans.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Blood Pressure; Electrocardiogra | 2011 |
[Activation of Rho-kinase pathway is involved in angiotensin II-induced contraction of human airway smooth muscle cells].
Topics: Amides; Angiotensin II; Asthma; Biphenyl Compounds; Bronchi; Humans; Irbesartan; Muscle Contraction; | 2011 |
Functional comparison of the antagonistic properties of some Angiotensin II type 1 receptor blockers on the contraction elicited by Angiotensin II and thromboxane A2 on human saphenous veins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin II T | 2003 |
Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist.
Topics: Adrenal Cortex; Angiotensin Receptor Antagonists; Animals; Aorta; Binding Sites; Biphenyl Compounds; | 1993 |
Mechanistic differences of various AT1-receptor blockers in isolated vessels of different origin.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimida | 1999 |
Novel angiotensin II AT(1) receptor antagonist irbesartan prevents thromboxane A(2)-induced vasoconstriction in canine coronary arteries and human platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin Receptor Antagonists | 2000 |