Page last updated: 2024-10-29

avapro and Elevated Cholesterol

avapro has been researched along with Elevated Cholesterol in 9 studies

Irbesartan: A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.
irbesartan : A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

Research Excerpts

ExcerptRelevanceReference
"A once-daily combination product of irbesartan and atorvastatin provided an effective, safe, and more compliable treatment for patients with coexisting hypertension and hyperlipidemia."9.22Blood Pressure and Cholesterol-lowering Efficacy of a Fixed-dose Combination With Irbesartan and Atorvastatin in Patients With Hypertension and Hypercholesterolemia: A Randomized, Double-blind, Factorial, Multicenter Phase III Study. ( Chae, SC; Cho, DG; Chung, MH; Ha, JW; Han, GR; Hyon, MS; Jo, SH; Kim, CH; Kim, DW; Kim, KS; Kim, SH; Kim, YD; Lee, HL; Lee, NH; Lee, SC; Lee, SY; Oh, BH; Park, CG; Ryu, GH; Seung, KB; Yoon, MH, 2016)
"Cardiac hypertrophy is not only an adaptational state before heart failure but also is an independent risk factor for ischemia, arrhythmia, and sudden death."5.36The inhibitory effects of rosiglitazone on cardiac hypertrophy through modulating the renin-angiotensin system in diet-induced hypercholesterolemic rats. ( Hu, D; Li, Y; Liu, N; Ren, L; Sheng, Z; Tang, R, 2010)
"A once-daily combination product of irbesartan and atorvastatin provided an effective, safe, and more compliable treatment for patients with coexisting hypertension and hyperlipidemia."5.22Blood Pressure and Cholesterol-lowering Efficacy of a Fixed-dose Combination With Irbesartan and Atorvastatin in Patients With Hypertension and Hypercholesterolemia: A Randomized, Double-blind, Factorial, Multicenter Phase III Study. ( Chae, SC; Cho, DG; Chung, MH; Ha, JW; Han, GR; Hyon, MS; Jo, SH; Kim, CH; Kim, DW; Kim, KS; Kim, SH; Kim, YD; Lee, HL; Lee, NH; Lee, SC; Lee, SY; Oh, BH; Park, CG; Ryu, GH; Seung, KB; Yoon, MH, 2016)
"Hypercholesterolemia is an important risk factor for atherosclerotic vascular disease including stroke."2.73Effects of angiotensin II type 1-receptor blockade on retinal endothelial function. ( Harazny, J; Michelson, G; Ott, C; Schlaich, MP; Schmidt, BM; Schmieder, RE, 2008)
"Atherosclerosis is a chronic inflammatory disease in which the renin-angiotensin-aldosterone system plays an important role."1.36Molecular mechanisms of irbesartan suppressing atherosclerosis in high cholesterol-diet apolipoprotein E knock-out mice. ( Chen, Y; Cheng, X; Ding, YJ; Liao, MY; Liao, YH; Tang, TT; Xie, JJ; Yao, R; Yu, X, 2010)
"Cardiac hypertrophy is not only an adaptational state before heart failure but also is an independent risk factor for ischemia, arrhythmia, and sudden death."1.36The inhibitory effects of rosiglitazone on cardiac hypertrophy through modulating the renin-angiotensin system in diet-induced hypercholesterolemic rats. ( Hu, D; Li, Y; Liu, N; Ren, L; Sheng, Z; Tang, R, 2010)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, SH1
Jo, SH1
Lee, SC1
Lee, SY1
Yoon, MH1
Lee, HL1
Lee, NH2
Ha, JW1
Kim, DW1
Han, GR1
Hyon, MS1
Cho, DG1
Park, CG1
Kim, YD1
Ryu, GH1
Kim, CH1
Kim, KS1
Chung, MH1
Chae, SC1
Seung, KB1
Oh, BH1
Yao, R1
Cheng, X1
Chen, Y1
Xie, JJ1
Yu, X1
Liao, MY1
Ding, YJ1
Tang, TT1
Liao, YH1
Ren, L1
Li, Y2
Tang, R1
Hu, D1
Sheng, Z1
Liu, N1
Alexandru, N2
Popov, D2
Dragan, E2
Andrei, E2
Georgescu, A2
Titorencu, I1
Tarziu, C1
Ghiorghe, S1
Badila, E1
Bartos, D1
Chade, AR1
Rodriguez-Porcel, M1
Rippentrop, SJ1
Lerman, A1
Lerman, LO1
Morawietz, H1
Erbs, S1
Holtz, J1
Schubert, A1
Krekler, M1
Goettsch, W1
Kuss, O1
Adams, V1
Lenk, K1
Mohr, FW1
Schuler, G1
Hambrecht, R1
Ott, C1
Schlaich, MP1
Harazny, J1
Schmidt, BM1
Michelson, G1
Schmieder, RE1
Sanz, M1
Ganado, P1
Tejerina, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Coadministered Irbesartan and Atorvastatin in Patients With Hypertension and Hyperlipidemia[NCT01442987]Phase 3230 participants (Actual)Interventional2011-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for avapro and Elevated Cholesterol

ArticleYear
Blood Pressure and Cholesterol-lowering Efficacy of a Fixed-dose Combination With Irbesartan and Atorvastatin in Patients With Hypertension and Hypercholesterolemia: A Randomized, Double-blind, Factorial, Multicenter Phase III Study.
    Clinical therapeutics, 2016, Volume: 38, Issue:10

    Topics: Aged; Antihypertensive Agents; Atorvastatin; Biphenyl Compounds; Blood Pressure; Cholesterol; Double

2016
Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial.
    Circulation, 2006, Jul-04, Volume: 114, Issue:1 Suppl

    Topics: Angiotensin II Type 1 Receptor Blockers; Atherosclerosis; Biphenyl Compounds; Blood Pressure; Choles

2006
Effects of angiotensin II type 1-receptor blockade on retinal endothelial function.
    Journal of hypertension, 2008, Volume: 26, Issue:3

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Double-Blind Method; Endothelium

2008

Other Studies

6 other studies available for avapro and Elevated Cholesterol

ArticleYear
Molecular mechanisms of irbesartan suppressing atherosclerosis in high cholesterol-diet apolipoprotein E knock-out mice.
    International journal of cardiology, 2010, Mar-04, Volume: 139, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Bipheny

2010
The inhibitory effects of rosiglitazone on cardiac hypertrophy through modulating the renin-angiotensin system in diet-induced hypercholesterolemic rats.
    Cell biochemistry and function, 2010, Volume: 28, Issue:1

    Topics: Angiotensin II; Animals; Biphenyl Compounds; Cardiomegaly; Cholesterol, Dietary; Hypercholesterolemi

2010
Platelet activation in hypertension associated with hypercholesterolemia: effects of irbesartan.
    Journal of thrombosis and haemostasis : JTH, 2011, Volume: 9, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxidants; Biphenyl Co

2011
Circulating microparticles and endothelial progenitor cells in atherosclerosis: pharmacological effects of irbesartan.
    Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atherosclerosis; Biphenyl Compounds; Blood Pressur

2012
Angiotensin II AT1 receptor blockade improves renal perfusion in hypercholesterolemia.
    American journal of hypertension, 2003, Volume: 16, Issue:2

    Topics: Acetylcholine; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Hemodynamics; Hypercho

2003
Two angiotensin AT1 receptor antagonists, irbesartan and losartan, effects in cholesterol-fed rabbits.
    European journal of pharmacology, 2002, May-03, Volume: 442, Issue:1-2

    Topics: Acetylcholine; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Chole

2002
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