avapro has been researched along with Alloxan Diabetes in 34 studies
Irbesartan: A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.
irbesartan : A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diabetic spontaneously hypertensive rats developed albuminuria and had a reduction in both gene and protein expression of nephrin when compared with control rats." | 7.71 | Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. ( Allen, TJ; Boner, G; Bonnet, F; Cao, Z; Cooper, ME; Kawachi, H, 2001) |
| "Cellular hypertrophy is an early, important pathological feature of renal diseases such as diabetic nephropathy and remnant kidney." | 5.33 | Connective tissue growth factor-mediated angiotensin II-induced hypertrophy of proximal tubular cells. ( Chen, L; Huang, HQ; Liu, BC; Liu, DG; Liu, H; Ma, KL; Sun, J; Zhang, XL, 2006) |
| "Treatment with irbesartan attenuates cardiac inflammation in type 2 diabetic db/db mice, and this effect was probably associated with the suppression of cardiac angiotensin II and NF-κB signaling pathway." | 3.83 | [Irbesartan ameliorates cardiac inflammation in type 2 diabetic db/db mice]. ( Gong, WQ; Huang, WC; Liang, Y; Liu, B; Yang, CM; Ye, XL; Zheng, YT, 2016) |
| "Diabetic spontaneously hypertensive rats developed albuminuria and had a reduction in both gene and protein expression of nephrin when compared with control rats." | 3.71 | Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. ( Allen, TJ; Boner, G; Bonnet, F; Cao, Z; Cooper, ME; Kawachi, H, 2001) |
| "HKC was administered to the diabetic nephropathy rats at three different doses: high dose HKC (300mg/kg/d); middle dose HKC (175mg/kg/d); and low dose HKC (75mg/kg/d)." | 1.43 | Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator-activated receptor (PPAR)-α/γ and attenuating endoplasmic reticulum stress in rats. ( Ge, J; Miao, JJ; Sun, XY; Yu, JY, 2016) |
| "Leptin may cause delayed gastric emptying in the central and peripheral pathways." | 1.40 | Improved gastric emptying in diabetic rats by irbesartan via decreased serum leptin and ameliorated gastric microcirculation. ( He, L; Ren, R; Sun, Y; Wang, F; Zhang, Y; Zhu, Y, 2014) |
| "T2DM rats were induced by fed with high-sucrose-high-fat diet combined with a low dose of streptozocin." | 1.38 | [Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model]. ( Li, YS; Liu, LQ; Ma, RX; Xu, Y; Zhang, J, 2012) |
| "To investigate the relationship between the dosage of irbesartan and the renal tissue structure in diabetic rats." | 1.36 | [Dose-effect relationship of irbsartan with the changes in the renal tissue structure in diabetic rats]. ( Fan, YF; Liu, S; Shen, J; Tang, JL; Xie, CH, 2010) |
| "Cellular hypertrophy is an early, important pathological feature of renal diseases such as diabetic nephropathy and remnant kidney." | 1.33 | Connective tissue growth factor-mediated angiotensin II-induced hypertrophy of proximal tubular cells. ( Chen, L; Huang, HQ; Liu, BC; Liu, DG; Liu, H; Ma, KL; Sun, J; Zhang, XL, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (50.00) | 29.6817 |
| 2010's | 17 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, XL | 1 |
| Huang, WC | 1 |
| Zheng, YT | 1 |
| Liang, Y | 1 |
| Gong, WQ | 1 |
| Yang, CM | 1 |
| Liu, B | 1 |
| Zhang, H | 2 |
| Tao, M | 1 |
| Kang, PF | 1 |
| Guo, JL | 1 |
| Xuan, L | 1 |
| Gao, Q | 1 |
| Tang, B | 1 |
| Li, LJ | 1 |
| Wang, HJ | 1 |
| Zhao, X | 1 |
| Yang, D | 1 |
| Xu, W | 2 |
| Guo, Z | 1 |
| He, L | 1 |
| Sun, Y | 1 |
| Zhu, Y | 2 |
| Ren, R | 1 |
| Zhang, Y | 3 |
| Wang, F | 1 |
| Liu, X | 1 |
| Xu, Q | 1 |
| Wang, X | 1 |
| Zhao, Z | 1 |
| Zhang, L | 2 |
| Zhong, L | 1 |
| Li, L | 1 |
| Kang, W | 1 |
| Ge, Z | 1 |
| Chen, WD | 1 |
| Chang, BC | 1 |
| Yang, P | 1 |
| Liu, L | 1 |
| Yu, QX | 1 |
| Xu, WH | 1 |
| Hao, F | 1 |
| Liu, SL | 1 |
| Bai, MM | 1 |
| Mu, JW | 1 |
| Zhang, HJ | 1 |
| Ge, J | 1 |
| Miao, JJ | 1 |
| Sun, XY | 1 |
| Yu, JY | 1 |
| Tunçdemir, M | 1 |
| Öztürk, M | 1 |
| Prasad, T | 1 |
| Roksnoer, LC | 1 |
| Zhu, P | 1 |
| Verma, A | 1 |
| Li, Y | 1 |
| Batenburg, WW | 1 |
| de Vries, R | 1 |
| Danser, AH | 1 |
| Li, Q | 3 |
| Vieitez, P | 1 |
| Gómez, O | 1 |
| Uceda, ER | 1 |
| Vera, ME | 1 |
| Molina-Holgado, E | 1 |
| Sen, S | 2 |
| Saniye, S | 1 |
| Kanter, M | 2 |
| Mehmet, K | 1 |
| Ustundag, S | 2 |
| Sedat, U | 1 |
| Aktas, C | 2 |
| Cevat, A | 1 |
| Dogutan, H | 1 |
| Yalcin, O | 1 |
| Omer, Y | 1 |
| Ren, X | 1 |
| Guan, G | 1 |
| Liu, G | 2 |
| Failli, P | 1 |
| Alfarano, C | 1 |
| Franchi-Micheli, S | 1 |
| Mannucci, E | 1 |
| Cerbai, E | 1 |
| Mugelli, A | 1 |
| Raimondi, L | 1 |
| Long, HB | 2 |
| Niu, HX | 1 |
| Li, XY | 1 |
| Zhou, WD | 2 |
| He, JH | 1 |
| Zhong, J | 2 |
| Wei, LB | 2 |
| Donmez, S | 1 |
| Erboga, M | 1 |
| Tang, JL | 2 |
| Shen, J | 2 |
| Liu, S | 2 |
| Fan, YF | 1 |
| Xie, CH | 1 |
| Hu, YY | 1 |
| Dai, HY | 3 |
| Zheng, M | 3 |
| Tang, RN | 3 |
| Ni, J | 3 |
| Ma, KL | 6 |
| Liu, BC | 7 |
| Lv, LL | 1 |
| Zhang, JD | 1 |
| Ma, RX | 1 |
| Xu, Y | 2 |
| Zhang, J | 1 |
| Li, YS | 1 |
| Liu, LQ | 1 |
| Bonnet, F | 2 |
| Candido, R | 2 |
| Carey, RM | 1 |
| Casley, D | 1 |
| Russo, LM | 1 |
| Osicka, TM | 1 |
| Cooper, ME | 3 |
| Cao, Z | 3 |
| Chen, Q | 1 |
| Luo, DD | 2 |
| Sun, J | 3 |
| Phillips, AO | 1 |
| Ruan, XZ | 2 |
| Liu, NF | 1 |
| Allen, TJ | 2 |
| Lassila, M | 1 |
| Thallas, V | 1 |
| Jandeleit-Dahm, KA | 1 |
| Huang, HQ | 2 |
| Yin, LF | 1 |
| Liu, DG | 2 |
| Chen, L | 2 |
| Liu, H | 1 |
| Zhang, XL | 1 |
| Ma, J | 1 |
| Gu, Y | 1 |
| Lin, S | 1 |
| Qian, XX | 1 |
| Chen, YM | 1 |
| Wu, WK | 1 |
| Liu, Y | 1 |
| Zhou, B | 1 |
| Liu, JL | 1 |
| Westermann, D | 1 |
| Rutschow, S | 1 |
| Jäger, S | 1 |
| Linderer, A | 1 |
| Anker, S | 1 |
| Riad, A | 1 |
| Unger, T | 1 |
| Schultheiss, HP | 1 |
| Pauschinger, M | 1 |
| Tschöpe, C | 1 |
| Xu, ZZ | 1 |
| Huang, Z | 1 |
| Jansson, L | 1 |
| Sjöholm, A | 1 |
| Kawachi, H | 1 |
| Boner, G | 1 |
34 other studies available for avapro and Alloxan Diabetes
| Article | Year |
|---|---|
[Irbesartan ameliorates cardiac inflammation in type 2 diabetic db/db mice].
Topics: Actins; Angiotensin II; Animals; Biphenyl Compounds; Cardiovascular Diseases; Diabetes Mellitus, Exp | 2016 |
[Effects of irbesartan on Notch1 signaling pathway in diabetic rats with myocardial injury].
Topics: Animals; Diabetes Mellitus, Experimental; Irbesartan; Myocardium; Rats; Rats, Sprague-Dawley; Recept | 2018 |
Effect of Irbesartan on Oxidative Stress and Serum Inflammatory Factors in Renal Tissues of Type 2 Diabetic Rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Exper | 2019 |
Improved gastric emptying in diabetic rats by irbesartan via decreased serum leptin and ameliorated gastric microcirculation.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blood Glucose; Diabetes Compli | 2014 |
Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model.
Topics: Animals; Biphenyl Compounds; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2015 |
[Effect of Tripterygium glycosides on expression of hypoxia inducible factor-1α and endothelin-1 in kidney of diabetic rats].
Topics: Animals; Biphenyl Compounds; Blood Glucose; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Expe | 2015 |
Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats.
Topics: Animals; Biphenyl Compounds; Chemokines; Diabetes Mellitus, Experimental; Intercellular Signaling Pe | 2015 |
Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator-activated receptor (PPAR)-α/γ and attenuating endoplasmic reticulum stress in rats.
Topics: Abelmoschus; Administration, Oral; Albuminuria; Animals; Biphenyl Compounds; Capsules; Diabetes Mell | 2016 |
Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosi | 2016 |
Beneficial Effects of Combined AT1 Receptor/Neprilysin Inhibition (ARNI) Versus AT1 Receptor Blockade Alone in the Diabetic Eye.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blotting, Western; Diabetes Me | 2016 |
Systemic and local effects of angiotensin II blockade in experimental diabetic nephropathy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blotting, West | 2008 |
Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on streptozotocin-induced diabetic nephropathy.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl | 2008 |
Irbesartan ameliorates diabetic nephropathy by reducing the expression of connective tissue growth factor and alpha-smooth-muscle actin in the tubulointerstitium of diabetic rats.
Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blood Glucose; Connect | 2009 |
Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Biphenyl Co | 2009 |
[Effects of irbesartan on renal advanced glycation end products and their receptor in rats with early diabetic nephropathy].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Diabetes Mellitus, Experimenta | 2009 |
Protective effects of irbesartan and alpha lipoic acid in STZ-induced diabetic nephropathy in rats.
Topics: Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Immuno | 2010 |
[Dose-effect relationship of irbsartan with the changes in the renal tissue structure in diabetic rats].
Topics: Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Irbe | 2010 |
[Effect of irbesartan on ACE2 expression in diabetic rat myocardium].
Topics: Angiotensin-Converting Enzyme 2; Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Irbes | 2010 |
Effects of angiotensin receptor blocker on phenotypic alterations of podocytes in early diabetic nephropathy.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biomarkers; | 2011 |
Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blotting, Western; Calcium-Bin | 2013 |
Inhibition of integrin-linked kinase by angiotensin II receptor antagonist, irbesartan attenuates podocyte injury in diabetic rats.
Topics: Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Enzy | 2012 |
[Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model].
Topics: Animals; Biphenyl Compounds; Bone Morphogenetic Protein 7; Connective Tissue Growth Factor; Diabetes | 2012 |
Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade.
Topics: Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diab | 2002 |
Mechanisms of irbesartan in prevention of renal lesion in streptozotocin-induced diabetic rats.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Connective T | 2003 |
[Influence of irbesartan on renal hypertrophy and thickening of glomerular basement-membrane in streptozotocin-induced diabetic rats].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Basement Membrane; Biphenyl Compounds; Diabetes Me | 2003 |
Irbesartan but not amlodipine suppresses diabetes-associated atherosclerosis.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aortic Diseas | 2004 |
Effects of irbesartan on the expression of matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 in streptozotocin-induced diabetic rat kidney.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Creatinine; Diabetes Mellitus, | 2005 |
Connective tissue growth factor-mediated angiotensin II-induced hypertrophy of proximal tubular cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cell Cycle; Ce | 2006 |
Effects of blocking the renin-angiotensin system on expression and translocation of protein kinase C isoforms in the kidney of diabetic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Biologic | 2006 |
[Effects of irbesartan on nitric oxide system in the heart of diabetic rats].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Diabetes Mellitus, Experimenta | 2006 |
Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cardiomyopathies; Collagen Typ | 2007 |
[Effects of angiotensin II receptor antagonist on rat podocyte injury in early diabetic nephropathy].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Desmin; Diabetes Mellitus, Exp | 2007 |
Gender-specific regulation of pancreatic islet blood flow, insulin levels and glycaemia in spontaneously diabetic Goto-Kakizaki rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl | 2008 |
Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension.
Topics: Albuminuria; Analysis of Variance; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Di | 2001 |