australine has been researched along with Gaucher Disease in 1 studies
*Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Álvarez, E; García Fernández, JM; Ortiz Mellet, C; Sánchez-Fernández, EM | 1 |
1 other study(ies) available for australine and Gaucher Disease
| Article | Year |
|---|---|
Synthesis of multibranched australine derivatives from reducing castanospermine analogues through the Amadori rearrangement of gem-diamine intermediates: selective inhibitors of β-glucosidase.
Topics: beta-Glucosidase; Biochemical Phenomena; Diamines; Enzyme Inhibitors; Gaucher Disease; Humans; Indolizidines; Indolizines; Molecular Chaperones; Molecular Structure; Pyrrolizidine Alkaloids | 2014 |