austdiol has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for austdiol and Neoplasms
| Article | Year |
|---|---|
A novel tricyclic polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic fungus Dothideomycete sp.
Azaphilone derivatives 1 and 2 and a novel tricyclic polyketide 3, together with a known azaphilone, austdiol (4), were isolated from the endophytic fungus Dothideomycete sp., which was isolated from a Thai medicinal plant, Tiliacora triandra. Compound 3 is the first polyketide having a tricyclic 6,6,6 ring system, which is similar to that of a terpenoid skeleton. The absolute configurations of stereogenic centers in 1-3 were addressed by Mosher's method and biosynthetic analogy with a known azaphilone isolated from the same fungus. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated. Topics: Aldehydes; Anti-Bacterial Agents; Antineoplastic Agents; Benzopyrans; Cell Line, Tumor; Fungi; Humans; Neoplasms; Pigments, Biological; Plants, Medicinal; Polyketides; Staphylococcal Infections; Staphylococcus aureus | 2012 |