aurotioprol and Kidney-Diseases

Analysis is made of the results of the treatment with parenteral (crysanol and myochrysine) and oral (ridaura) gold drugs as well as with small doses of D-penicillamine (DP) of patients suffering from rheumatoid arthritis with the signs of nephropathy. The latter ones were identified, respectively, in 18 out of 80 patients who began receiving treatment, in 17 out of 72, and in 16 out of 61 patients. The clinical, laboratory, instrumental and morphological manifestations of nephropathy are described and analysis of their dynamics under the treatment impact is provided. It is noted that these types of basic therapy produce a beneficial effect on the manifestations of rheumatoid nephropathy. That referred to a greater measure to the gold drugs than to the small doses of DP. The degree of counteracting the symptoms of renal pathology agreed well with a good clinical effect in respect to the articular syndrome and inflammatory responses of blood. Among patients receiving crysanol, iatrogenic nephropathy was recorded in 8.75% of cases, among those on ridaura, in 2.8%, and those on DP, in 8.2% of cases. The authors provide evidence for the use of gold drugs and DP in patients suffering from rheumatoid nephropathy.

Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Dimercaprol; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Injections; Kidney Diseases; Organogold Compounds; Organometallic Compounds; Penicillamine; Propanols; Prospective Studies; Sulfhydryl Compounds; Time Factors

Titers of circulating antigalactosyl antibodies (a-Gal Ab) were assessed by passive hemagglutination using rabbit red blood cells in 40 normal subjects, in 14 patients with immunodeficient states, in 47 patients with active rheumatoid arthritis (RA), and in 15 patients with an Henoch-Schönlein disease (HS). Titers of controls ranged from 1:16 to 1:64. All immunodeficient patients exhibited very low titers (1:1). On the contrary, the existence of an enhanced humoral immune response status, as observed in RA, was not reflected by a parallel increase of a-Gal Ab titers. However, in this disease, a strong relationship existed between titers exceeding control values (greater than 1:64) and the prior occurrence of renal injury under gold or D-penicillamine therapy. Lastly, the discovery of elevated titers (greater than 1:64) in HS only when renal involvement occurred further suggests that such antibodies reflect a renal injury.

Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Antibody Formation; Antibody Specificity; Arthritis, Rheumatoid; Child; Child, Preschool; Dimercaprol; Female; Gold; Hemagglutination Tests; Humans; IgA Vasculitis; Immune Complex Diseases; Immunoglobulin G; Infant; Kidney; Kidney Diseases; Male; Middle Aged; Multiple Myeloma; Organogold Compounds; Organometallic Compounds; Penicillamine; Propanols; Sulfhydryl Compounds