auriculasin has been researched along with Colorectal-Neoplasms* in 1 studies
1 other study(ies) available for auriculasin and Colorectal-Neoplasms
| Article | Year |
|---|---|
Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation.
Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apoptosis, led to mitochondrial shrinkage, and increased the intracellular accumulation of Fe Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Fabaceae; Ferroptosis; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Iron; Isoflavones; Kelch-Like ECH-Associated Protein 1; Malondialdehyde; Mitochondria; Mitochondrial Proteins; Models, Biological; Phosphoprotein Phosphatases; Plant Extracts; Reactive Oxygen Species | 2022 |