aurapten and Pneumonia

aurapten has been researched along with Pneumonia* in 1 studies

Other Studies

1 other study(ies) available for aurapten and Pneumonia

ArticleYear
Auraptene alleviates inflammatory injury and cell apoptosis in children with pneumonia
    Allergologia et immunopathologia, 2023, Volume: 51, Issue:6

    The aim of the present study is to investigate the effects of auraptene on inflammation and apoptosis of pneumonia cell model and uncover the mechanism.. WI-38 cells were treated with lipopolysaccharide (LPS) to construct a pneumonia model. Cell counting kit-8 assay, enzyme-linked-immunosorbent serologic assay, and quantitative polymerase chain reaction assay were conducted to confirm the effects of auraptene on the viability and inflammation of WI-38 cells. Flow cytometry (FCM) and immunoblot assays were conducted to detect the effects of auraptene on the apoptosis of WI-38 cells. Immunoblot assay was performed to confirm the mechanism.. We found that auraptene stimulated cell viability in WI-38 cells upon LPS treatment. Auraptene also inhibited cellular inflammation. Furthermore, auraptene inhibited cell apoptosis of WI-38 cells upon LPS treatment. Mechanically, auraptene inhibited the nuclear factor kappa B signaling pathway, thereby suppressing the pneumonia.. Auraptene alleviates inflammatory injury and cell apoptosis in pneumonia, thus has the potential to act as a pneumonia drug.

    Topics: Apoptosis; Child; Humans; Inflammation; Lipopolysaccharides; MicroRNAs; Pneumonia

2023