au-006 and Myocardial-Infarction

Coronary artery disease (CAD) has emerged as the major cause of morbidity and mortality among Asian Indians in the recent past. The following study was undertaken to assess the predictive value of novel biomarkers of dyslipidemia for risk assessment for CAD in the Indian population.. The study group comprised of 100 clinically assessed patients of myocardial infarction and 100 age and sex matched healthy controls. Apolipoprotein-A (Apo-AI) and Apolipoprotein-B (Apo-B) were estimated and small dense LDL was derived mathematically.. The cases showed significantly high levels of total serum cholesterol, triglycerides, LDL cholesterol, Apo-B, sdLDL, and non-HDL cholesterol. On carrying out multivariate regression analysis, Lp(a)/HDL ratio emerged as the best determinant of CAD risk. The above data clearly underlines the role of these novel biomarkers in the risk assessment for CAD in the Indian context.

Topics: Adult; Aged; Case-Control Studies; Cholesterol; Coronary Artery Disease; Dyslipidemias; Female; Humans; India; Lipoproteins; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Quinolines; Regression Analysis; Risk Assessment; ROC Curve; Triglycerides