atrial-natriuretic-factor has been researched along with Substance-Related-Disorders* in 3 studies
3 other study(ies) available for atrial-natriuretic-factor and Substance-Related-Disorders
| Article | Year |
|---|---|
Atrial natriuretic peptide modulates N-methyl-D-aspartate-induced hyperexcitability in ethanol-dependent mice.
The role of central nervous atrial natriuretic peptide was investigated for behavioral hyperexcitability in alcohol-dependent mice. Mice were made tolerant to and dependent on ethanol with an ethanol-liquid diet for 14 days. Five hours after withdrawal from ethanol, withdrawal symptoms were analyzed by scoring handling-induced convulsions. N-methyl-D-aspartate (NMDA) induced behavioral seizures in a dose-dependent manner, an effect which was more intensive during the ethanol withdrawal period than in alcohol-naive animals. Intracerebroventricular (i.c.v.) injections of alpha-atrial natriuretic peptide (atrial natriuretic peptide) dose-dependently inhibited, whereas injection of an antiserum against atrial natriuretic peptide potentiated, the seizure-inducing effect of NMDA in ethanol-dependent mice. The main conclusion is that central nervous atrial natriuretic peptide plays a modulatory role in behavioral hyperexcitability during alcohol withdrawal. Topics: Animals; Atrial Natriuretic Factor; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Immune Sera; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Seizures; Substance-Related Disorders | 2000 |
Uneventful self poisoning with a very high dose of captopril.
A 43-year-old patient with mild heart failure attempted suicide by ingesting between 5000 and 7500 mg of captopril. Blood pressure oscillated around 100-120/50-75 mmHg and pulse rate showed no tendency to accelerate (75-100/min). The psychiatric examination showed no drug induced psychopathological symptoms. The calculated half-life of captopril was 4.4 h. Seven hours after ingestion of approximately 50 times the maximal therapeutic daily dose of captopril the serum concentration reached 20 micrograms/ml. The calculated amount of absorbed captopril was approximately 5400 mg. Atrial natriuretic factor (ANF) plasma levels were slightly elevated and showed no tendency to increase or to fall. Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Captopril; Half-Life; Humans; Male; Substance-Related Disorders; Suicide, Attempted | 1990 |
Indomethacin and atrial natriuretic peptide in pseudo-Bartter's syndrome.
Topics: Adult; Atrial Natriuretic Factor; Bartter Syndrome; Female; Furosemide; Humans; Hyperaldosteronism; Indomethacin; Male; Substance-Related Disorders | 1987 |