atrial-natriuretic-factor has been researched along with Nephritis* in 2 studies
1 review(s) available for atrial-natriuretic-factor and Nephritis
| Article | Year |
|---|---|
Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: benefits of atrial natriuretic peptide, losartan, and tempol.
The body regulates plasma sodium levels within a small physiologic range, despite large variations in daily sodium and water intake. It is known that sodium transport in the kidneys plays an important role in hypoxia, being the major determinant of renal oxygen consumption. Tubular epithelial cell hypoxia is an important contributor to the development of renal inflammation, and the damage may progress to structural injury, ending in acute renal failure. In this review, we will summarize the renal inflammatory effects of high acute plasma sodium (acute hypernatremia), and the molecular mechanisms involved. We will also discuss recent findings related to the role of oxidative stress and angiotensin II (Ang II) in the pathogenesis of renal injury. We will comment on the effects of agents used to prevent or attenuate the inflammatory response, such as the atrial natriuretic peptide, the superoxide dismutase mimetic - tempol, and losartan. Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cyclic N-Oxides; Humans; Hypernatremia; Losartan; Nephritis; Oxidative Stress; Spin Labels | 2015 |
1 other study(ies) available for atrial-natriuretic-factor and Nephritis
| Article | Year |
|---|---|
Renal effects of synthetic rat-atrial natriuretic peptide in nephron-reduced rats with nephrotoxic nephritis.
Following nephron reduction by means of five--sixths nephrectomy (Nx), nephritis was induced in rats by injection of nephrotoxic serum (NTS). A continuous intravenous infusion of synthetic rat--atrial natriuretic peptide (r-ANP) at 2.5 micrograms/min for produced remarkable diuresis and natriuresis in these rats. Furthermore, inulin clearance, para-amino-hippuric acid clearance and filtration fraction increased in spite of the reduction of mean arterial pressure during the infusion of r-ANP. It was therefore evident that diuresis and natriuresis were mediated by a direct action of r-ANP in the kidney. We observed that r-ANP was a diuretic, natriuretic and hypotensive agent but at a higher dosage in Nx rats with NTN. Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Diuresis; Glomerular Filtration Rate; Immune Sera; Kidney; Male; Natriuresis; Nephrectomy; Nephritis; Rats; Rats, Inbred Strains | 1987 |