atrial-natriuretic-factor and Infertility--Female

The effect of tokishakuyakusan, a Chinese herbal medicine, was examined, in vivo, in women with luteal insufficiency and in women with normal menstrual cycles. Luteal insufficiency was determined by daily measurement of basal body temperature and plasma progesterone levels. Tokishakuyakusan improved luteal insufficiency. Furthermore, the effects of tokishakuyakusan on prolactin, gonadotropins, steroids, angiotensin II, ANP and renin levels in the blood of women with normal menstrual cycles were studied, as were the medicine's effects on estrogens, pregnenediol and LH in the urine of the same women. Tokishakuyakusan had no adverse effect on hormonal levels in either blood or urine. Furthermore, no clinical side effects were detected. These results suggest that tokishakuyakusan improves luteal insufficiency in women but does not affect the hormonal levels of women with normal menstrual cycles.

Topics: Adult; Angiotensin II; Atrial Natriuretic Factor; Body Temperature; Drugs, Chinese Herbal; Estradiol; Female; Fertility Agents; Follicle Stimulating Hormone; Gonadotropins; Humans; Infertility, Female; Luteal Phase; Luteinizing Hormone; Menstrual Cycle; Phytotherapy; Plants, Medicinal; Progesterone; Prolactin; Renin