atrial-natriuretic-factor and Glioblastoma

atrial-natriuretic-factor has been researched along with Glioblastoma* in 2 studies

Other Studies

2 other study(ies) available for atrial-natriuretic-factor and Glioblastoma

Article	Year
CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells. The EMBO journal, 2011, Aug-19, Volume: 30, Issue:20 Cancer stem cells or cancer initiating cells are believed to contribute to cancer recurrence after therapy. MicroRNAs (miRNAs) are short RNA molecules with fundamental roles in gene regulation. The role of miRNAs in cancer stem cells is only poorly understood. Here, we report miRNA expression profiles of glioblastoma stem cell-containing CD133(+) cell populations. We find that miR-9, miR-9() (referred to as miR-9/9()), miR-17 and miR-106b are highly abundant in CD133(+) cells. Furthermore, inhibition of miR-9/9() or miR-17 leads to reduced neurosphere formation and stimulates cell differentiation. Calmodulin-binding transcription activator 1 (CAMTA1) is a putative transcription factor, which induces the expression of the anti-proliferative cardiac hormone natriuretic peptide A (NPPA). We identify CAMTA1 as an miR-9/9() and miR-17 target. CAMTA1 expression leads to reduced neurosphere formation and tumour growth in nude mice, suggesting that CAMTA1 can function as tumour suppressor. Consistently, CAMTA1 and NPPA expression correlate with patient survival. Our findings could provide a basis for novel strategies of glioblastoma therapy. Topics: AC133 Antigen; Animals; Antigens, CD; Atrial Natriuretic Factor; Calcium-Binding Proteins; Cell Differentiation; Cell Line, Tumor; Cohort Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycoproteins; Humans; Male; Mice; Mice, Nude; MicroRNAs; Neoplastic Stem Cells; Peptides; Trans-Activators; Transcriptome; Tumor Suppressor Proteins	2011
Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide. Cancer letters, 2007, Aug-28, Volume: 254, Issue:1 Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The four cardiac hormones decreased DNA synthesis 65-87% and increased cyclic GMP 1.3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present.. four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis. Topics: Animals; Antineoplastic Agents; Atrial Natriuretic Factor; Blotting, Western; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Dose-Response Relationship, Drug; Elapidae; Glioblastoma; Humans; Myocardium; Peptide Fragments; Peptides; Protein Precursors; Receptors, Atrial Natriuretic Factor; Time Factors	2007

Article

Year

CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells.

The EMBO journal, 2011, Aug-19, Volume: 30, Issue:20

Cancer stem cells or cancer initiating cells are believed to contribute to cancer recurrence after therapy. MicroRNAs (miRNAs) are short RNA molecules with fundamental roles in gene regulation. The role of miRNAs in cancer stem cells is only poorly understood. Here, we report miRNA expression profiles of glioblastoma stem cell-containing CD133(+) cell populations. We find that miR-9, miR-9(*) (referred to as miR-9/9(*)), miR-17 and miR-106b are highly abundant in CD133(+) cells. Furthermore, inhibition of miR-9/9(*) or miR-17 leads to reduced neurosphere formation and stimulates cell differentiation. Calmodulin-binding transcription activator 1 (CAMTA1) is a putative transcription factor, which induces the expression of the anti-proliferative cardiac hormone natriuretic peptide A (NPPA). We identify CAMTA1 as an miR-9/9(*) and miR-17 target. CAMTA1 expression leads to reduced neurosphere formation and tumour growth in nude mice, suggesting that CAMTA1 can function as tumour suppressor. Consistently, CAMTA1 and NPPA expression correlate with patient survival. Our findings could provide a basis for novel strategies of glioblastoma therapy.

Topics: AC133 Antigen; Animals; Antigens, CD; Atrial Natriuretic Factor; Calcium-Binding Proteins; Cell Differentiation; Cell Line, Tumor; Cohort Studies; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycoproteins; Humans; Male; Mice; Mice, Nude; MicroRNAs; Neoplastic Stem Cells; Peptides; Trans-Activators; Transcriptome; Tumor Suppressor Proteins

2011

Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide.

Cancer letters, 2007, Aug-28, Volume: 254, Issue:1

Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The four cardiac hormones decreased DNA synthesis 65-87% and increased cyclic GMP 1.3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present.. four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis.

Topics: Animals; Antineoplastic Agents; Atrial Natriuretic Factor; Blotting, Western; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Dose-Response Relationship, Drug; Elapidae; Glioblastoma; Humans; Myocardium; Peptide Fragments; Peptides; Protein Precursors; Receptors, Atrial Natriuretic Factor; Time Factors

2007