atrial-natriuretic-factor and Cardiac-Output--High

atrial-natriuretic-factor has been researched along with Cardiac-Output--High* in 2 studies

Other Studies

2 other study(ies) available for atrial-natriuretic-factor and Cardiac-Output--High

ArticleYear
Captopril enhances renal responsiveness to ANF in dogs with compensated high-output heart failure.
    The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 2

    The systemic hemodynamic, hormonal, and renal effects of chronic angiotensin-converting enzyme inhibition (CEI) with captopril and the responses to synthetic atrial natriuretic factor (ANF) infusions in the presence and absence of captopril were examined in normal dogs (n = 6) and in dogs with an arteriovenous (AV) fistula and compensated high-output heart failure (n = 6). This experimental model is characterized by normalization of the circulating renin-angiotensin-aldosterone system (RAAS) and persistent elevations in central filling pressures and plasma ANF. In both normal and AV-fistula dogs, oral captopril for 1 wk at 35 mg.kg-1.day-1 in three divided doses produced progressive reductions in arterial and atrial pressures (P less than 0.05), plasma ANF (P less than 0.05), and aldosterone (P less than 0.05). After 1-2 days of a modest increase in urinary sodium excretion (UNaV) (P less than 0.05), all of the dogs regained and maintained sodium balance during captopril administration. On the 8th day of the captopril regimen, synthetic ANF was infused at 15 and 30 ng.kg-1.min-1 for 75-min periods each. Control infusion experiments were performed in the same animals before captopril administration. The normal dogs exhibited dose-related elevations in UNaV (P less than 0.05) that were not augmented with captopril (P greater than 0.05). In contrast, in the AV-fistula dogs the observed renal unresponsiveness to synthetic ANF in the control experiments was reversed with chronic CEI, and ANF-induced UNaV achieved levels comparable to those obtained in the normal animals.(ABSTRACT TRUNCATED AT 250 WORDS)

    Topics: Aldosterone; Analysis of Variance; Animals; Arteriovenous Fistula; Atrial Natriuretic Factor; Blood Pressure; Captopril; Cardiac Output, High; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Natriuresis; Recombinant Proteins; Reference Values; Renin-Angiotensin System

1992
Chronic captopril and losartan (DuP 753) administration in rats with high-output heart failure.
    The American journal of physiology, 1992, Volume: 263, Issue:3 Pt 2

    We investigated the role of atrial natriuretic factor (ANF) and the renin-angiotensin system as well as the effects of losartan in rats with aortocaval (AC) shunts. Right atrial and left ventricular end-diastolic pressures (LVEDP) were higher and mean arterial blood pressure (MAP) was lower in AC shunt animals than in their controls. AC shunt rats presented marked cardiac hypertrophy, decreased right atrial ANF concentration, and increased ventricular ANF content and concentration. Plasma ANF levels were elevated, and hematocrit was lower in AC shunt animals than in controls. Captopril or losartan treatment decreased MAP and returned LVEDP to sham-operated control values. A clear regression of cardiac hypertrophy was evident in both treated AC shunt groups, with plasma ANF levels tending to follow those in sham-operated rats. Plasma COOH-terminal ANF levels were decreased and urinary volume and hematocrit were increased in losartan-treated AC shunt animals. We conclude that chronic angiotensin converting enzyme inhibition and angiotension II receptor antagonism improved hemodynamic conditions, diminished water retention, reversed cardiac hypertrophy, and restored plasma and tissue ANF to more "normal" levels in rats with moderate high-output heart failure.

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Body Fluids; Captopril; Cardiac Output, High; Cardiomegaly; Hemodynamics; Homeostasis; Imidazoles; Losartan; Male; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Time Factors

1992