atrasentan has been researched along with Hypertension in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (19.05) | 18.2507 |
| 2000's | 32 (50.79) | 29.6817 |
| 2010's | 17 (26.98) | 24.3611 |
| 2020's | 2 (3.17) | 2.80 |
| Authors | Studies |
|---|---|
| Bądzyńska, B; Hojná, S; Kompanowska-Jezierska, E; Sadowski, J; Vaneckova, I | 1 |
| Červenka, L; Gawrys, O; Jíchová, Š; Kala, P; Kompanowska-Jezierska, E; Maxová, H; Miklovič, M; Sadowski, J; Škaroupková, P; Táborský, M; Vaněčková, I; Vaňourková, Z; Veselka, J; Walkowska, A | 1 |
| Andress, DL; Bakris, G; Brennan, JJ; Correa-Rotter, R; de Zeeuw, D; Heerspink, HJL; Hou, FF; Kitzman, DW; Kohan, D; Makino, H; McMurray, J; Parving, HH; Perkovic, V; Tobe, S; Wigderson, M; Yi, T | 1 |
| Bkaily, G; Brochu, I; D'Orléans-Juste, P; Desbiens, L; Gobeil, F; Houde, M; Semaan, W; Simard, E | 1 |
| Chang, NC; Chung, TH; Lee, TM; Lin, SZ | 1 |
| El-Din, MM; El-Mas, MM; Elmallah, AI; Khedr, MM; Nasser, SA; Sabra, R | 2 |
| Jeon, Y; Jin, C; Kleven, DT; Pollock, DM; Pollock, JS; White, JJ | 1 |
| Dobešová, Z; Kuneš, J; Vaněčková, I; Vernerová, Z; Zicha, J | 1 |
| Kang, JJ; Kang, PM; Ke, Q; Kim, UK; Samad, MA | 1 |
| Coelho, SC; Fraulob-Aquino, JC; Huo, KG; Offermanns, S; Paradis, P; Rautureau, Y; Rehman, A; Schiffrin, EL | 1 |
| Harris, A; Kyle, PB; Morris, R; Owens, MY; Spencer, SK; Wallace, K; Williams, JM | 1 |
| Cheng, G; Li, B; Li, Y; Liu, D; Lu, S; Xiao, J; Yuan, W; Zhao, Z | 1 |
| Carneiro, FS; Carneiro, ZN; Ergul, A; Giachini, FR; Leite, R; Lima, VV; Nunes, KP; Tostes, RC; Webb, RC | 1 |
| Holmes, DR; Kent, B; Lerman, A; Lerman, LO; Mathew, V; Nelson, RE; Prasad, A; Pumper, GM; Raichlin, E | 1 |
| Carneiro, FS; Carneiro, ZN; Clinton Webb, R; Ergul, A; Giachini, FR; Leite, R; Lima, VV; Nogueira, EF; Nunes, KP; Rainey, WE; Tostes, RC | 1 |
| Nakano, D; Pollock, DM | 1 |
| Albert, DH; Banfor, PN; Cox, BF; Davidsen, SK; Franklin, PA; Fryer, RM; Gintant, GA; Segreti, JA; Widomski, DL | 1 |
| Cockrell, K; Dechend, R; Glover, P; LaMarca, B; Martin, JN; Murphy, SR; Parrish, M; Ray, LF; Roberts, L; Ryan, MJ; Wallukat, G; Wenzel, K | 1 |
| Carneiro, FS; Carneiro, ZN; Carvalho, MH; Ergul, A; Fortes, ZB; Giachini, FR; Lima, VV; Pollock, DM; Saleh, MA; Tostes, RC; Webb, RC | 1 |
| Bäcker, A; Cervenka, L; Kramer, HJ; Kujal, P; Vaneckova, I; Vernerová, Z | 1 |
| D'Angelo, G; Loria, AS; Pollock, DM; Pollock, JS | 1 |
| Boesen, EI; Pollock, DM; Pollock, JS | 1 |
| Arany, M; Cockrell, K; George, E; Granger, JP; Lamarca, B; Martin, JN; Speed, J; Tam Tam, KB | 1 |
| Kimura, K; Koyama, M; Matsumura, Y; Ohkita, M | 1 |
| Heath, J; LaMarca, B; Martin, JN; Moseley, J; Novotny, S; Owens, MY; Wallace, K | 1 |
| Burke, SE; Cox, BF; Opgenorth, TJ; Preusser, LC; Reinhart, GA; Wegner, CD; Wessale, JL | 1 |
| Horio, T; Johnson, RJ; Kangawa, K; Kawano, Y; Suga, S; Yasui, N; Yoshihara, F | 1 |
| Berthelot, A; Berthon, N; Fellmann, D; Laurant, P | 1 |
| Ergul, A; Fuchs, LC; Giulumian, AD; Molero, MM; Portik-Dobos, V | 1 |
| Banes, AK; Chen, AF; Fink, GD; Galligan, JJ; Li, L; Watts, SW | 1 |
| Chen, AF; Fink, GD; Hesslinger, C; Kapatos, G; Kovesdi, I; Lookingland, KJ; Yang, XQ; Zheng, JS | 1 |
| da Silva, AA; Hall, JE; Kuo, JJ; Tallam, LS | 1 |
| Cucchiarelli, VE; Fortepiani, LA; Gomez-Sanchez, CE; Reckelhoff, JF; Romero, DG; Santacruz, F; Yanes, LL | 1 |
| Dabbs Loomis, E; Elmarakby, AA; Pollock, DM; Pollock, JS | 1 |
| Bkaily, G; Brochu, I; D'Orleans-Juste, P; Fecteau, MH; Honoré, JC; Labonté, J | 1 |
| Bennett, W; Cockrell, K; Granger, JP; LaMarca, BB; Sullivan, E | 1 |
| Allan, A; Brown, L; Fenning, A; Hoey, A; Levick, S | 1 |
| Bäcker, A; Cervenka, L; Kramer, HJ; Opocensky, M; Vanêcková, I; Vernerová, Z | 1 |
| Banfor, PN; Cox, BF; Fryer, RM; Opgenorth, TJ; Rakestraw, PA; Reinhart, GA | 1 |
| Bäcker, A; Cervenka, L; Dvorák, P; Eis, V; Kramer, HJ; Opocenský, M; Schejbalová, S; Vanecková, I; Vernerová, Z | 1 |
| Hasegawa, Y; Kawanishi, H; Matsumura, Y; Nakano, D; Ohkita, M; Ohno, Y; Takaoka, M | 1 |
| Fink, G; Lau, Y; Li, M; Osborn, J; Watts, S | 1 |
| Deng, LY; Schiffrin, EL; Turgeon, A | 1 |
| Schiffrin, EL; Sharifi, AM | 1 |
| Clower, B; Granger, JP; Kassab, S; Miller, MT; Novak, J; Reckelhoff, J | 1 |
| He, G; Schiffrin, EL; Sharifi, AM; Touyz, RM | 1 |
| Braam, B; Gröne, HJ; Joles, JA; Koomans, HA; Opgenorth, TJ; Rabelink, TJ; Verhagen, AM | 1 |
| Clarke, N; Fuchs, LC; Giulumian, AD; Pollock, DM | 1 |
| Opgenorth, TJ; Polakowski, JS; Pollock, DM; Pollock, JS | 1 |
| Li, JS; Schiffrin, EL; Turgeon, A | 1 |
| Allcock, GH; Pollock, DM; Venema, RC | 1 |
| Intengan, HD; Schiffrin, EL | 1 |
| Blezer, EL; Goldschmeding, R; Jansen, GH; Joles, JA; Koomans, HA; Nicolay, K; Rabelink, TJ | 1 |
| Hashimoto, N; Kitano, R; Kuro, T; Matsumura, Y; Ohkita, M; Opgenorth, TJ; Taira, S; Takaoka, M | 1 |
| Fink, GD; Galligan, JJ; Johnson, RJ | 1 |
| Bianciotti, LG; De Bold, AJ | 1 |
| Ammarguellat, F; Larouche, I; Schiffrin, EL | 1 |
| Alexander, BT; Bennett, WA; Cockrell, KL; Granger, JP; Massey, MB; Rinewalt, AN | 1 |
| Alexander, BT; Cockrell, KL; Granger, JP; Herrington, JN; Rinewalt, AN | 1 |
| Derebail, VK; Pollock, DM; Pollock, JS; Yamamoto, T | 1 |
| Ballew, JR; Fink, GD | 1 |
| Enseleit, F; Hürlimann, D; Lüscher, TF; Noll, G; Ruschitzka, F | 1 |
3 review(s) available for atrasentan and Hypertension
| Article | Year |
|---|---|
Endothelin-receptor antagonist can reduce blood pressure in patients with hypertension: a meta-analysis.
Topics: Antihypertensive Agents; Atrasentan; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension; Middle Aged; Models, Statistical; Phenylpropionates; Pyridines; Pyrimidines; Pyrrolidines; Randomized Controlled Trials as Topic; Sulfonamides; Survival Analysis; Tetrazoles | 2017 |
End-organ damage in hypertensive transgenic Ren-2 rats: influence of early and late endothelin receptor blockade.
Topics: Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Bosentan; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Glomerulosclerosis, Focal Segmental; Heterozygote; Homozygote; Hypertension; Male; Podocytes; Pyrrolidines; Rats; Rats, Transgenic; Receptor, Endothelin A; Receptor, Endothelin B; Renin; Sodium Chloride, Dietary; Sulfonamides; Time Factors | 2009 |
Endothelin antagonists and heart failure.
Topics: Atrasentan; Bosentan; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Hemodynamics; Humans; Hypertension; Pyrrolidines; Receptors, Endothelin; Sulfonamides | 2002 |
2 trial(s) available for atrasentan and Hypertension
| Article | Year |
|---|---|
Baseline characteristics and enrichment results from the SONAR trial.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atrasentan; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diuretics; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Precision Medicine; Renal Insufficiency; Risk | 2018 |
Efficacy and safety of atrasentan in patients with cardiovascular risk and early atherosclerosis.
Topics: Adult; Antihypertensive Agents; Atrasentan; Blood Glucose; Blood Pressure; Coronary Artery Disease; Edema; Endothelin A Receptor Antagonists; Endothelin-1; Female; Follow-Up Studies; Humans; Hypertension; Kidney; Lipid Metabolism; Male; Metabolic Syndrome; Middle Aged; Pyrrolidines; Receptor, Endothelin A; Risk Factors; Treatment Outcome | 2008 |
58 other study(ies) available for atrasentan and Hypertension
| Article | Year |
|---|---|
Effects of systemic and renal intramedullary endothelin-1 receptor blockade on tissue NO and intrarenal hemodynamics in normotensive and hypertensive rats.
Topics: Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension; Kidney; Nitric Oxide; Oligopeptides; Piperidines; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Endothelin A; Renal Elimination | 2021 |
Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrasentan; Endothelin-1; Endothelins; Fistula; Heart Failure; Hypertension; Rats; Rats, Transgenic; Receptor, Angiotensin, Type 1; Receptor, Endothelin A | 2023 |
High salt-induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Atrasentan; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Peptides, Cyclic; Pyrrolidines; Receptor, Bradykinin B2; Sodium; Sodium Chloride, Dietary; Telemetry | 2013 |
Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Atrasentan; Blood Pressure; Desoxycorticosterone Acetate; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Gene Expression Regulation; Hypertension; Kidney; Male; Proteinuria; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Sodium Chloride, Dietary | 2014 |
Blockade of endothelin ET(A), but not thromboxane, receptors offsets the cyclosporine-evoked hypertension and interrelated baroreflex and vascular dysfunctions.
Topics: Animals; Atrasentan; Blood Pressure; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Heart Rate; Hypertension; Male; Naphthalenes; Nitric Oxide; Nitric Oxide Synthase Type III; Propionates; Pyrrolidines; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Thromboxane; Signal Transduction; Time Factors; Vasodilation; Vasodilator Agents | 2014 |
Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antihypertensive Agents; Arterial Pressure; Atrasentan; Cell Adhesion Molecules; Chlorthalidone; Deoxyguanosine; Disease Models, Animal; Diuretics; Drug Combinations; Endothelin A Receptor Antagonists; Endothelins; Hypertension; Inflammation; Kidney Diseases; Male; Membrane Proteins; Metabolic Syndrome; Oxidative Stress; Proteinuria; Pyrrolidines; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium Chloride, Dietary | 2014 |
Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet.
Topics: Animal Feed; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Calcium; Calcium Channels, L-Type; Captopril; Endothelin A Receptor Antagonists; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Pentolinium Tartrate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary; Sympathetic Nervous System; Vasoconstriction; Vasodilation | 2015 |
Endothelin A receptor antagonist, atrasentan, attenuates renal and cardiac dysfunction in Dahl salt-hypertensive rats in a blood pressure independent manner.
Topics: Animals; Atrasentan; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Endothelin A Receptor Antagonists; Gene Expression; Heart Diseases; Hemodynamics; Hypertension; Hypertrophy; Kidney Function Tests; Male; Myocytes, Cardiac; Phenylephrine; Pyrrolidines; Rats; Receptor, Endothelin A; Renal Insufficiency, Chronic | 2015 |
Inducible human endothelin-1 overexpression in endothelium raises blood pressure via endothelin type A receptors.
Topics: Animals; Atrasentan; Blood Pressure; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Humans; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Tamoxifen; Up-Regulation | 2015 |
Hypertension in an Animal Model of HELLP Syndrome is Associated With Activation of Endothelin 1.
Topics: Animals; Atrasentan; Disease Models, Animal; Endoglin; Endothelin-1; Female; HELLP Syndrome; Hypertension; Placenta; Pregnancy; Pyrrolidines; Rats; Vascular Endothelial Growth Factor Receptor-1 | 2016 |
Facilitation by the renin-angiotensin system of cyclosporine-evoked hypertension in rats: Role of arterial baroreflexes and vasoreactivity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Angiotensin II; Animals; Aorta; Atrasentan; Baroreflex; Blood Pressure; Captopril; Cyclosporine; Hypertension; Indomethacin; Losartan; Male; Naphthalenes; Nitric Oxide Synthase Type III; Nitroprusside; Oligopeptides; Phenylephrine; Piperidines; Propionates; Pyrrolidines; Rats; Renin-Angiotensin System; Vasoconstriction; Vasodilation | 2016 |
DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum.
Topics: Animals; Atrasentan; Desoxycorticosterone; Endothelin A Receptor Antagonists; Endothelin-1; Hypertension; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth; Penile Erection; Penis; Pyrrolidines; RNA, Messenger; Sodium Chloride; Vasodilation | 2008 |
Activation of the ET-1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension.
Topics: Animals; Atrasentan; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Endothelin-1; Erectile Dysfunction; Gene Expression; Hypertension; In Vitro Techniques; Male; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Penis; Pyrrolidines; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger | 2008 |
Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats.
Topics: Animals; Atrasentan; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Kidney Medulla; Male; Natriuresis; Pyrrolidines; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Sex Characteristics; Sodium | 2009 |
ETA receptor blockade with atrasentan prevents hypertension with the multitargeted tyrosine kinase inhibitor ABT-869 in telemetry-instrumented rats.
Topics: Angiogenesis Inhibitors; Animals; Area Under Curve; Atrasentan; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Endothelin A Receptor Antagonists; Heart Rate; Hypertension; Indazoles; Male; Phenylurea Compounds; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Telemetry | 2009 |
Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.
Topics: Animals; Atrasentan; Autoantibodies; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Kidney; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy, Animal; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 | 2009 |
O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin 1.
Topics: Acetylglucosamine; Animals; Aorta, Thoracic; Atrasentan; Blood Pressure; Blotting, Western; Desoxycorticosterone; Drug Synergism; Endothelin-1; Glycoproteins; Glycosylation; Hypertension; In Vitro Techniques; Male; N-Acetylglucosaminyltransferases; Phenylephrine; Pyrrolidines; Rats; Rats, Wistar; Time Factors; Vasoconstriction; Vasoconstrictor Agents | 2010 |
Endothelin activation of reactive oxygen species mediates stress-induced pressor response in Dahl salt-sensitive prehypertensive rats.
Topics: Animals; Atrasentan; Blood Pressure; Carbon Radioisotopes; Cyclic N-Oxides; Endothelins; Free Radical Scavengers; Hypertension; Pyrrolidines; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Reactive Oxygen Species; Spin Labels; Stress, Psychological; Sulfonamides | 2010 |
Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Hypertension; Male; Nitrates; Nitrites; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Treatment Outcome | 2010 |
Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance.
Topics: Animals; Atrasentan; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Endothelin Receptor Antagonists; Female; Hypertension; Ischemia; Placenta; Pregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Ultrasonography; Uterine Artery; Vascular Resistance | 2011 |
Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats.
Topics: Animals; Atrasentan; Desoxycorticosterone; Disease Models, Animal; Disease Susceptibility; Endothelin-1; Hypertension; Kidney Diseases; Male; NF-kappa B; Nitric Oxide; Nitroarginine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Severity of Illness Index; Sodium Chloride, Dietary; Thiocarbamates | 2012 |
Hypertension in response to CD4(+) T cells from reduced uterine perfusion pregnant rats is associated with activation of the endothelin-1 system.
Topics: Adoptive Transfer; Animals; Atrasentan; Blood Pressure; CD4-Positive T-Lymphocytes; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Ischemia; Models, Animal; Placenta; Pregnancy; Pregnancy, Animal; Pyrrolidines; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Signal Transduction; Uterus | 2012 |
Hypertension induced by blockade of ET(B) receptors in conscious nonhuman primates: role of ET(A) receptors.
Topics: Animals; Antineoplastic Agents; Atrasentan; Blood Pressure; Consciousness; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; Homeostasis; Hypertension; Macaca fascicularis; Male; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Telemetry | 2002 |
Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms.
Topics: Albuminuria; Animals; Atrasentan; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Hypertrophy; Hypokalemia; Kidney; Kidney Diseases; Kidney Tubules; Male; Potassium; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B | 2003 |
Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats.
Topics: Animals; Aorta; Atrasentan; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Heart Rate; Heart Ventricles; Hypertension; Kidney; Magnesium Oxide; Male; Organ Size; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2003 |
Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation.
Topics: Animals; Aorta, Thoracic; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Male; Matrix Metalloproteinases; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin A; Stress, Physiological; Up-Regulation | 2003 |
NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension.
Topics: Acetophenones; Allopurinol; Animals; Atrasentan; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Venae Cavae; Viper Venoms; Xanthine Oxidase | 2003 |
Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.
Topics: Acetophenones; Animals; Antioxidants; Atrasentan; Biopterins; Carotid Arteries; Cyclic N-Oxides; Desoxycorticosterone; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Gene Transfer Techniques; Genetic Therapy; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Male; Nitric Oxide; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium Chloride; Spin Labels; Superoxides; Vasodilation | 2003 |
Role of endothelin-1 in blood pressure regulation in a rat model of visceral obesity and hypertension.
Topics: Adipose Tissue; Animals; Atrasentan; Blood Pressure; Body Weight; Eating; Endothelin A Receptor Antagonists; Endothelin-1; Fats; Heart Rate; Hormones; Hypertension; Kidney; Male; Obesity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Viscera | 2004 |
Role of endothelin in mediating postmenopausal hypertension in a rat model.
Topics: Animals; Atrasentan; Endothelin A Receptor Antagonists; Endothelin-1; Endothelins; Female; Gene Expression; Hypertension; Kidney Cortex; Postmenopause; Pyrrolidines; Rats; Rats, Inbred SHR; Receptor, Endothelin A; RNA, Messenger | 2005 |
ETA receptor blockade attenuates hypertension and decreases reactive oxygen species in ETB receptor-deficient rats.
Topics: Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta; Atrasentan; Blood Pressure; Dinoprost; Disease Models, Animal; Down-Regulation; Endothelin A Receptor Antagonists; Endothelins; Hypertension; Male; Pyrrolidines; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Sodium Chloride, Dietary; Superoxides; Time Factors | 2004 |
Concomitant antagonism of endothelial and vascular smooth muscle cell ETB receptors for endothelin induces hypertension in the hamster.
Topics: Anesthesia; Animals; Atrasentan; Blood Pressure; Consciousness; Cricetinae; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Hypertension; Male; Mesocricetus; Muscle, Smooth, Vascular; Peptide Fragments; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B | 2005 |
Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats.
Topics: Animals; Aorta; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin-1; Endothelins; Female; Hypertension; Kidney; Placenta; Pregnancy; Pregnancy Complications, Cardiovascular; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Reversal of cardiac dysfunction by selective ET-A receptor antagonism.
Topics: Acetylcholine; Action Potentials; Animals; Aorta, Thoracic; Atrasentan; Body Weight; Collagen; Desoxycorticosterone; Disease Models, Animal; Drinking; Endothelin A Receptor Antagonists; Hypertension; Hypertrophy, Left Ventricular; In Vitro Techniques; Male; Myocardial Contraction; Nephrectomy; Norepinephrine; Papillary Muscles; Potassium Chloride; Pyrrolidines; Rats; Rats, Wistar; Ventricular Remodeling | 2005 |
Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats.
Topics: Animals; Animals, Genetically Modified; Atrasentan; Blood Pressure; Body Weight; Bosentan; Cardiomegaly; Endothelin A Receptor Antagonists; Endothelin-1; Glomerulosclerosis, Focal Segmental; Heart Ventricles; Hypertension; Kidney; Male; Myocardium; Organ Size; Osmolar Concentration; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Renin; Sodium Chloride, Dietary; Sulfonamides; Survival Analysis | 2005 |
Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade.
Topics: Animals; Atrasentan; Blood Pressure; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Heart Rate; Hypertension; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptor, Endothelin A; Telemetry | 2006 |
Early-onset endothelin receptor blockade in hypertensive heterozygous Ren-2 rats.
Topics: Animals; Animals, Genetically Modified; Antihypertensive Agents; Atrasentan; Blood Pressure; Body Weight; Bosentan; Cardiomegaly; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Glomerulosclerosis, Focal Segmental; Heterozygote; Hypertension; Male; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Renin; Sodium Chloride, Dietary; Sulfonamides; Time Factors | 2006 |
Involvement of the endothelin ET(B) receptor in gender differences in deoxycorticosterone acetate-salt-induced hypertension.
Topics: Animals; Aorta, Thoracic; Atrasentan; Blood Pressure; Desoxycorticosterone; Dopamine beta-Hydroxylase; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Mice, Transgenic; Organ Size; Ovariectomy; Pyrrolidines; Rats; Receptor, Endothelin B; Sex Factors; Superoxides; Uterus; Weight Gain | 2007 |
Chronic activation of endothelin B receptors: new model of experimental hypertension.
Topics: Animals; Atrasentan; Blood Pressure; Blood Volume; Cardiac Output; Disease Models, Animal; Diuresis; Drug Administration Schedule; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Heart Rate; Hypertension; Male; Natriuresis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Stroke Volume; Sulfonamides; Vascular Resistance; Viper Venoms | 2007 |
Effect of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats.
Topics: Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; Hypertension; Hypertension, Renovascular; Male; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Renin | 1997 |
Apoptosis in aorta of deoxycorticosterone acetate-salt hypertensive rats: effect of endothelin receptor antagonism.
Topics: Animals; Aorta; Apoptosis; Atrasentan; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Male; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1997 |
Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats.
Topics: Animals; Atrasentan; Blood Pressure; Diet, Sodium-Restricted; Endothelin Receptor Antagonists; Glomerular Filtration Rate; Hemodynamics; Hypertension; Kidney; Male; Natriuresis; Potassium; Proteinuria; Pyrrolidines; Rats; Rats, Inbred Strains; Receptor, Endothelin A; Regional Blood Flow; Sodium; Sodium, Dietary; Systole | 1998 |
Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atrasentan; Blood Pressure; Blood Vessels; Blotting, Northern; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Mesenteric Arteries; Muscle Contraction; Organ Size; Pyrrolidines; Rats; Rats, Inbred SHR; Receptor, Endothelin A; RNA, Messenger | 1998 |
Endothelin A receptor blockade alleviates hypertension and renal lesions associated with chronic nitric oxide synthase inhibition.
Topics: Animals; Atrasentan; Blood Pressure; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; Kidney; Male; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Time Factors | 1998 |
Coronary vascular reactivity is improved by endothelin A receptor blockade in DOCA-salt hypertensive rats.
Topics: Animals; Atrasentan; Blood Pressure; Coronary Vessels; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Male; Mesenteric Arteries; Potassium Chloride; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium Chloride; Vasoconstriction | 1998 |
Role of endothelin ET(A) receptors in the hypertension produced by 4-day L-nitroarginine methyl ester and cyclosporine treatment.
Topics: Animals; Atrasentan; Cyclosporine; Drinking Behavior; Endothelin Receptor Antagonists; Enzyme Inhibitors; Feeding Behavior; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin | 1998 |
Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Topics: Animals; Arteries; Atrasentan; Blood Pressure; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium Chloride; Time Factors | 1998 |
ETA receptor blockade attenuates the hypertension but not renal dysfunction in DOCA-salt rats.
Topics: Animals; Atrasentan; Blood Pressure; Creatinine; Desoxycorticosterone; Endothelin Receptor Antagonists; Endothelin-1; Glomerular Filtration Rate; Hypertension; Kidney; Kidney Cortex; Kidney Medulla; Male; Nephrectomy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Sodium, Dietary; Stereoisomerism; Time Factors; Transcription, Genetic; Water-Electrolyte Balance | 1998 |
Mechanical properties of mesenteric resistance arteries from Dahl salt-resistant and salt-sensitive rats: role of endothelin-1.
Topics: Animals; Atrasentan; Biomechanical Phenomena; Blood Pressure; Disease Models, Animal; Elasticity; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Pyrrolidines; Rats; Receptor, Endothelin A; Sodium Chloride; Vascular Resistance | 1998 |
Early-onset but not late-onset endothelin-A-receptor blockade can modulate hypertension, cerebral edema, and proteinuria in stroke-prone hypertensive rats.
Topics: Animals; Atrasentan; Blood Pressure; Brain Edema; Data Interpretation, Statistical; Endothelin Receptor Antagonists; Hypertension; Hypertension, Malignant; Kidney; Magnetic Resonance Imaging; Male; Proteinuria; Pyrrolidines; Rats; Rats, Inbred SHR; Sodium Chloride, Dietary; Stereoisomerism; Time Factors | 1999 |
Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats.
Topics: Animals; Aorta; Atrasentan; Desoxycorticosterone; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Hypertension; Male; Nephrectomy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin | 1999 |
Mechanisms of increased venous smooth muscle tone in desoxycorticosterone acetate-salt hypertension.
Topics: Animals; Atrasentan; Blood Volume; Consciousness; Desoxycorticosterone; Endothelin Receptor Antagonists; Ganglionic Blockers; Hexamethonium; Hypertension; Jugular Veins; Male; Muscle Tonus; Muscle, Smooth, Vascular; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sodium Chloride, Dietary; Sympathetic Nervous System | 2000 |
Effect of selective ET(A) receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension.
Topics: Animals; Atrasentan; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Desoxycorticosterone; Endothelin Receptor Antagonists; Gene Expression Regulation; Heart; Heart Ventricles; Hypertension; Male; Myocardium; Myosin Heavy Chains; Natriuretic Peptide, Brain; Organ Size; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium, Dietary; Transcription, Genetic | 2000 |
Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism.
Topics: Animals; Atrasentan; Blood Pressure; Collagen; Collagen Type I; Desoxycorticosterone; Endothelin A Receptor Antagonists; Fibrosis; Hypertension; Male; Myocardium; Organ Size; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Endothelin type a receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure.
Topics: Animals; Atrasentan; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Female; Hypertension; Kidney Cortex; Kidney Medulla; Perfusion; Pregnancy; Pregnancy Complications, Cardiovascular; Protein Precursors; Pyrrolidines; Rats; Receptor, Endothelin A; RNA, Messenger; Uterus | 2001 |
Enhanced renal expression of preproendothelin mRNA during chronic angiotensin II hypertension.
Topics: Angiotensin II; Animals; Atrasentan; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Gene Expression Regulation; Glomerular Filtration Rate; Hemodynamics; Hypertension; Infusions, Intravenous; Kidney; Kidney Cortex; Kidney Medulla; Male; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Renal Circulation; RNA, Messenger; Transcription, Genetic; Urodynamics | 2001 |
Combined effects of AT(1) and ET(A) receptor antagonists, candesartan, and A-127722 in DOCA-salt hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrasentan; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Desoxycorticosterone; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Kidney; Male; Natriuresis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 2000 |
Role of ET(A) receptors in experimental ANG II-induced hypertension in rats.
Topics: Angiotensin II; Animals; Atrasentan; Blood Pressure; Endothelin Receptor Antagonists; Heart Rate; Hypertension; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sodium Chloride, Dietary; Vasoconstrictor Agents; Water-Electrolyte Balance | 2001 |