atractylon and Inflammation

atractylon has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for atractylon and Inflammation

Article	Year
Atractylone, an active constituent of KMP6, attenuates allergic inflammation on allergic rhinitis in vitro and in vivo models. Molecular immunology, 2016, Volume: 78 KMP6 (Pyeongwee-San) is a Korean Medicine used to treat gastrointestinal disorders. Recently, we reported KMP6 had beneficial effects on allergic inflammatory diseases. The aim of this study was to evaluate the effects of atractylone (Atr), a constituent of KMP6, on allergic rhinitis (AR) and to identify the mechanism responsible for these effects. The anti-allergic inflammatory effects of Atr were evaluated on phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells and in an ovalbumin (OVA)-induced AR animal model using Western blotting, quantitative real-time PCR, ELISA, and immunohistochemistry methods. In HMC-1 cells, Atr and KMP6 attenuated PMACI-caused proinflammatory cytokine production and mRNA expression. We found that PMACI induced caspase-1/nuclear factor (NF)-κB/mitogen activated protein kinases (MAPKs) activation. PMACI-caused caspase-1/NF-κB/MAPKs activations were attenuated by Atr and KMP6. In AR animal model, Atr and KMP6 reduced AR clinical symptoms and biomarkers including rub scores, total IgE, histamine, prostaglandin D Topics: Animals; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Inflammation; Mast Cells; Mice; Mice, Inbred BALB C; Nasal Mucosa; Plant Extracts; Real-Time Polymerase Chain Reaction; Rhinitis, Allergic; Sesquiterpenes; Tandem Mass Spectrometry	2016

Article

Year

Atractylone, an active constituent of KMP6, attenuates allergic inflammation on allergic rhinitis in vitro and in vivo models.

Molecular immunology, 2016, Volume: 78

KMP6 (Pyeongwee-San) is a Korean Medicine used to treat gastrointestinal disorders. Recently, we reported KMP6 had beneficial effects on allergic inflammatory diseases. The aim of this study was to evaluate the effects of atractylone (Atr), a constituent of KMP6, on allergic rhinitis (AR) and to identify the mechanism responsible for these effects. The anti-allergic inflammatory effects of Atr were evaluated on phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells and in an ovalbumin (OVA)-induced AR animal model using Western blotting, quantitative real-time PCR, ELISA, and immunohistochemistry methods. In HMC-1 cells, Atr and KMP6 attenuated PMACI-caused proinflammatory cytokine production and mRNA expression. We found that PMACI induced caspase-1/nuclear factor (NF)-κB/mitogen activated protein kinases (MAPKs) activation. PMACI-caused caspase-1/NF-κB/MAPKs activations were attenuated by Atr and KMP6. In AR animal model, Atr and KMP6 reduced AR clinical symptoms and biomarkers including rub scores, total IgE, histamine, prostaglandin D

Topics: Animals; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Inflammation; Mast Cells; Mice; Mice, Inbred BALB C; Nasal Mucosa; Plant Extracts; Real-Time Polymerase Chain Reaction; Rhinitis, Allergic; Sesquiterpenes; Tandem Mass Spectrometry

2016