atractyligenine and Ovarian-Neoplasms

atractyligenine has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for atractyligenine and Ovarian-Neoplasms

Article	Year
Cytotoxic activity of some natural and synthetic ent-kauranes. Journal of natural products, 2007, Volume: 70, Issue:3 Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 microM, respectively. These two 1-analogues are promising lead compounds for further investigation. Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Atractyloside; Diterpenes, Kaurane; Drug Screening Assays, Antitumor; Female; Humans; Lamiaceae; Molecular Structure; Ovarian Neoplasms; Plants, Medicinal; Tumor Cells, Cultured	2007

Article

Year

Cytotoxic activity of some natural and synthetic ent-kauranes.

Journal of natural products, 2007, Volume: 70, Issue:3

Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 microM, respectively. These two 1-analogues are promising lead compounds for further investigation.

Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Atractyloside; Diterpenes, Kaurane; Drug Screening Assays, Antitumor; Female; Humans; Lamiaceae; Molecular Structure; Ovarian Neoplasms; Plants, Medicinal; Tumor Cells, Cultured

2007