atractylenolide-ii has been researched along with Breast-Neoplasms* in 2 studies
2 other study(ies) available for atractylenolide-ii and Breast-Neoplasms
| Article | Year |
|---|---|
Atractylenolide II induces cell cycle arrest and apoptosis in breast cancer cells through ER pathway.
In this research, atractylenolide II (ATR II) on apoptosis, cell cycle cells via ER pathway in breast cancer (MDA-MB-231 and MCF-7) cells are assessed. The effect of ATR II on cell proliferation was detected by MTT assay. Additional flow cytometry, luciferase, the western blot were performed to detect the signaling pathway cytotoxicity of ATR II. We have also carried out autodock measurements to validate our results. Our findings showed ATR II could inhibit breast cancer cell growth by apoptosis mainly through G2/M-phase cell cycle arrest. Besides, the cytotoxicity of ATTR II on breast cancer was also correlated by the regulation of endrogen receptors and promising an anti-inflammatory activity via inhibiting NF-KB signaling pathways. Taking together, ATR II could be a potential anti-cancer drug for breast cancer. Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Lactones; MCF-7 Cells; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Sesquiterpenes; Signal Transduction | 2021 |
Screening active components of modified Xiaoyao powder as NRF2 agonists.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) regulates antioxidant enzymes and phase II detoxifying enzymes, such as NAD(P)H: quinone oxidoreductase 1 (NQO1). Modified Xiaoyao powder (MXP) is most frequently used in the prevention and treatment of breast cancer in China. This study aimed to screen active components of MXP for antioxidant stress and chemoprevention, which depend on NRF2-NQO1 signalling pathway. A total of 25 monomeric compounds contained in MXP were screened using an antioxidant response element-luciferase reporter. The most potent antioxidant response element-luciferase inducers were chosen to further examine their effects on NRF2 and NQO1 in MCF-7 cells. These results were then confirmed by determining the oxidative stress levels and chemopreventive effect on inhibiting carcinogenesis transformation in NRF2 knockdown (NRF2 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cells, Cultured; Chemoprevention; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; Kaempferols; Lactones; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Quercetin; Sesquiterpenes; Structure-Activity Relationship | 2017 |