Page last updated: 2024-08-24

atorvastatin and Depression

atorvastatin has been researched along with Depression in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (11.76)29.6817
2010's10 (58.82)24.3611
2020's5 (29.41)2.80

Authors

AuthorsStudies
Cowen, PJ; De Giorgi, R; Harmer, CJ; Martens, M; Rizzo Pesci, N1
Abolmaali, M; Hosseinzadeh, A; Khotab, SJ; Mehrzadi, S; Mousavi, SZ; Nikoui, V1
Cong-Rong, T; Fan, Y; Hai-Na, Z; Jing, L; Lei-Mei, X; Ruo-Lan, S; Xu-Ben, Y; Yan-Cheng, C; Ye-Xuan, W1
Fan, H; Huang, J; Lai, X; Liu, A; Ma, H; Shen, M; Sun, W; Wu, J; Xu, Y; Yan, J; Yang, J1
Chen, BL; Chen, SM; Lai, CP; Lee, CH; Lee, JA; Lee, MC; Peng, TR; Shiang, JC; Wang, JY1
Cook, RL; Dave, CV; Hartzema, AG; Park, H; Winterstein, AG1
Drosdzol-Cop, A; Krysiak, R; Okopień, B; Skrzypulec-Plinta, V1
Buss, ZS; Doneda, DL; Ferreira, YS; Fraga-Junior, EB; Lima, E; Lopes, L; Rios-Santos, F; Stupp, IJV; Taniguti, EH; Vandresen-Filho, S; Viola, GG1
Binder, LB; Constantino, LC; Cunha, MP; Dal-Cim, T; Kuminek, G; Ludka, FK; Rodrigues, AL; Tasca, CI; Zomkowski, AD1
Dehpour, A; Jahanabadi, S; Javadi, S; Khoshnoodi, M; Mehr, SE; Shafaroodi, H; Shahsavarian, A; Shamsaee, J1
Berk, M; Li, X; Redlich, C; Sundquist, J; Sundquist, K; Williams, LJ1
Abbasi, SH; Akhondzadeh, S; Beglar, AA; Forghani, S; Mohammadinejad, P; Salehiomran, A; Shahmansouri, N; Zeinoddini, A1
Binder, LB; Constantino, LC; Dal-Cim, T; Ludka, FK; Rodrigues, AL; Tasca, CI; Zomkowski, A1
Davies, GR1
Cunha, MP; Dal-Cim, T; Ludka, FK; Rodrigues, AL; Tasca, CI; Zeni, AL; Zomkowski, AD1
Jick, H; Jick, SS; Yang, CC1
Browne, P; Connor, DJ; Johnson-Traver, S; Launer, LJ; Lochhead, J; Lopez, J; Petanceska, S; Sabbagh, MN; Sparks, DL; Wassar, D; Ziolkowski, C1

Reviews

1 review(s) available for atorvastatin and Depression

ArticleYear
Effects of various statins on depressive symptoms: A network meta-analysis.
    Journal of affective disorders, 2021, 10-01, Volume: 293

    Topics: Atorvastatin; Depression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Network Meta-Analysis

2021

Trials

3 trial(s) available for atorvastatin and Depression

ArticleYear
The effects of atorvastatin on emotional processing, reward learning, verbal memory and inflammation in healthy volunteers: An experimental medicine study.
    Journal of psychopharmacology (Oxford, England), 2021, Volume: 35, Issue:12

    Topics: Adolescent; Adult; Atorvastatin; Biomedical Research; C-Reactive Protein; Depression; Double-Blind Method; Emotions; Facial Recognition; Fear; Female; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Reward; Social Perception; Verbal Learning; Young Adult

2021
Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: A double-blind, placebo-controlled, randomized trial.
    Journal of affective disorders, 2015, Sep-01, Volume: 183

    Topics: Adult; Aged; Antidepressive Agents; Atorvastatin; Coronary Artery Bypass; Depression; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Percutaneous Coronary Intervention; Severity of Illness Index; Simvastatin; Treatment Outcome

2015
Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD.
    Current Alzheimer research, 2005, Volume: 2, Issue:3

    Topics: Activities of Daily Living; Aged; Alzheimer Disease; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cognition; Depression; Disease Progression; Double-Blind Method; Female; Free Radicals; Heptanoic Acids; Humans; Male; Mental Status Schedule; Pilot Projects; Pyrroles; Severity of Illness Index; Time Factors; Treatment Outcome

2005

Other Studies

13 other study(ies) available for atorvastatin and Depression

ArticleYear
Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors.
    Central nervous system agents in medicinal chemistry, 2023, Volume: 23, Issue:1

    Topics: Animals; Antidepressive Agents; Antioxidants; Atorvastatin; Depression; Melatonin; Mice; Oxidative Stress; Swimming

2023
Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice.
    Psychopharmacology, 2020, Volume: 237, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Depression; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hindlimb Suspension; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Male; Mice; Prefrontal Cortex; Streptozocin; Tumor Necrosis Factor-alpha

2020
Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice.
    Aging, 2020, 12-03, Volume: 13, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anxiety; Atorvastatin; Autophagy; Behavior, Animal; Depression; Gene Knockdown Techniques; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Movement; NADPH Oxidase 2; Neurotoxins; Oxidative Stress; Parkinsonian Disorders

2020
Comparative risk of lipophilic and hydrophilic statins on incident depression: A retrospective cohort study.
    Journal of affective disorders, 2018, 10-01, Volume: 238

    Topics: Adult; Aged; Atorvastatin; Depression; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Lovastatin; Male; Middle Aged; Pravastatin; Propensity Score; Retrospective Studies; Risk Factors; Rosuvastatin Calcium; Simvastatin; Suicide, Attempted; United States

2018
The effect of atorvastatin on sexual function and depressive symptoms in young women with elevated cholesterol levels - a pilot study.
    Endokrynologia Polska, 2018, Volume: 69, Issue:6

    Topics: Adult; Anticholesteremic Agents; Atorvastatin; Depression; Female; Humans; Hypercholesterolemia; Pilot Projects; Sexual Dysfunction, Physiological; Surveys and Questionnaires

2018
Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice.
    Brain research bulletin, 2019, Volume: 146

    Topics: Animals; Antidepressive Agents; Atorvastatin; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Disease Models, Animal; Fluoxetine; Hippocampus; Lipopolysaccharides; Male; Mice; Neuroprotective Agents; Oxidative Stress; Prefrontal Cortex; Tumor Necrosis Factor-alpha

2019
Atorvastatin evokes a serotonergic system-dependent antidepressant-like effect in mice.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 122

    Topics: Animals; Antidepressive Agents; Atorvastatin; Brain; Depression; Heptanoic Acids; Male; Mice; Pyrroles; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Treatment Outcome

2014
Antidepressant-like effect of atorvastatin in the forced swimming test in mice: the role of PPAR-gamma receptor and nitric oxide pathway.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Anilides; Animals; Antidepressive Agents; Atorvastatin; Depression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pioglitazone; PPAR gamma; Pyrroles; Signal Transduction; Swimming; Thiazolidinediones

2014
Statin use and risk of depression: a Swedish national cohort study.
    BMC psychiatry, 2014, Dec-04, Volume: 14

    Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Cohort Studies; Depression; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Population Surveillance; Pyrroles; Risk Factors; Simvastatin; Sweden

2014
Involvement of PI3K/Akt/GSK-3β and mTOR in the antidepressant-like effect of atorvastatin in mice.
    Journal of psychiatric research, 2016, Volume: 82

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Atorvastatin; Depression; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Glycogen Synthase Kinase 3 beta; Hindlimb Suspension; Immunosuppressive Agents; Male; Mice; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases

2016
Reversible dysphasia and statins.
    Journal of Korean medical science, 2012, Volume: 27, Issue:4

    Topics: Anticholesteremic Agents; Antihypertensive Agents; Anxiety; Aphasia; Atorvastatin; Cytochrome P-450 Enzyme System; Depression; Drug Interactions; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hypercholesterolemia; Indapamide; Middle Aged; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides

2012
Acute atorvastatin treatment exerts antidepressant-like effect in mice via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and increases BDNF levels.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2013, Volume: 23, Issue:5

    Topics: Animals; Antidepressive Agents; Arginine; Atorvastatin; Brain-Derived Neurotrophic Factor; Cyclic GMP; Depression; Heptanoic Acids; Male; Mice; Nitric Oxide; Pyrroles; Signal Transduction

2013
Lipid-lowering drugs and the risk of depression and suicidal behavior.
    Archives of internal medicine, 2003, Sep-08, Volume: 163, Issue:16

    Topics: Adult; Aged; Atorvastatin; Case-Control Studies; Depression; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Middle Aged; Multivariate Analysis; Pyrroles; Regression Analysis; Risk Factors; Suicide

2003