Page last updated: 2024-08-24

atorvastatin and Chemical and Drug Induced Liver Injury

atorvastatin has been researched along with Chemical and Drug Induced Liver Injury in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (3.51)	18.2507
2000's	17 (29.82)	29.6817
2010's	26 (45.61)	24.3611
2020's	12 (21.05)	2.80

Authors

Authors	Studies
Ahmad, S; Barrish, JC; Bird, E; Bisaha, S; Blanar, MA; Chang, M; Chen, BC; Chen, X; Cuff, CA; Darienzo, CJ; Giancarli, M; Harrity, T; Huang, C; Janovitz, E; Kennedy, LJ; Li, T; Madsen, CS; Monshizadegan, H; Ngu, K; Nguyen-Tran, V; Reeves, RA; Robl, JA; Ryan, CS; Search, D; Setters, R; Sitkoff, D; Stein, PD; Yin, X; Zahler, R; Zhang, R; Zhao, R; Zhuang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Björnsson, ES	2
Karimpour Malekshah, A; Mirzaei, M; Rahmani, Z; Rezaei Talarposhti, M; Talebpour Amiri, F; Zargari, M	1
García Pajares, F; Maroto-Martín, C; Molina Terrón, PM	1
Castermans, A; Hias, J; Spriet, I; Tournoy, J; Van der Linden, L	1
Li, Q; Liang, Y; Qin, L; Wang, Y; Xie, X; Zhang, H	1
Chen, NN; Li, JX; Ma, XD; Su, SW; Wang, CC; Wang, KX; Wu, YZ; Xiong, C	1
Li, XY; Mao, YM; Zhong, W	1
Liu, Z; Zeng, H	1
Chapman, G; Tanner, S	1
Bandegi, AR; Dehdashti, A; Ghanbari, A; Goodarzi, Z; Karami, E; Yousefi, S	1
An, J; Dong, Z; Ge, J; Liu, G; Lu, Y; Ma, X; Shi, H; Sun, A; Wang, Y; Xian, X; Yu, Q	1
Abdel-Rahman, RF; El-Kayal, M; Eltellawy, YA; Salah, S; Shaker, DS	1
Beyerle, A; Dietrich, B; Greene, B; Herzog, E; Kingwell, BA; Panjwani, P; Wright, SD	1
Aschmann, HE; Kaufmann, M; Puhan, MA; Yebyo, HG	1
Laube, R; Liu, K	1
Mohamed, MFH; Saeed, AAM; Salameh, OK	1
Doi, S; Kikuchi, K; Kuniyoshi, N; Mabuchi, M; Matsumoto, K; Miyakawa, H; Sekine, K; Tsujikawa, T; Tsunashima, H	1
El-Moselhy, MA; El-Sheikh, AA	1
Also, MA; Bastida, C; Letang, E; Miró, JM; Pericas, JM; Tuset, M	1
Chang, CH; Chang, YC; Chuang, LM; Lee, YC; Lin, JW; Liu, YC	1
Andrade, RJ; Carrascosa, MF; Lucena, MI; Salcines-Caviedes, JR	1
Pal, PB; Pal, S; Sarkar, A; Sil, PC	1
Bašić-Jukić, N; Ivandić, E	1
Bhattacharyya, S; Ghosh, M; Ghosh, S; Pal, S; Sil, PC	1
Deng, H; Hou, Z; Ju, L; Li, Y; Wang, L; Wang, Y; Xie, J; Zhang, Y; Zhang, Z	1
Fukunaga, K; Ishikawa, T; Kubo, M; Mushiroda, T; Nakagawa, H	1
Chen, Y; Li, B; Moorhead, JF; Ruan, XZ; Varghese, Z; Wu, W; Yang, P; Zhao, L; Zhou, W	1
Fang, RF; Gao, SQ; Li, JH; Pan, YT; Zhan, SY; Zhang, J	1
Hu, M; Li, F; Ling, Z; Liu, L; Liu, P; Liu, X; Shu, N; Sun, B; Wang, F; Xie, Q; Xu, P; Zhang, M; Zhong, Z	1
Abraldes, JG; Arroyo, V; Bataller, R; Colmenero, J; Dominguez, M; Egido, J; Ginès, P; Moreno, M; Ramalho, F; Ramalho, LN; Ruiz-Ortega, M; Sancho-Bru, P	1
Bonnet, J; Davignon, J; Martineau, P; McPherson, R; Nozza, A; Simoneau, D; Tedgui, A	1
Bonkovsky, HL; Russo, MW; Scobey, M	1
Adar, I; Golzman, G; Minha, S; Rapoport, M	1
Abd-Elghany, MI; Heeba, GH	1
Alencar, NM; Barboza, DR; Brito, GA; Gomes, AS; Leitão, RF; Macedo, RN; Medeiros, CA; Nogueira, NA; Ribeiro, RA	1
Bruggisser, M; Haschke, M; Rätz Bravo, A; Terraciano, L	1
Björnsson, E; Jacobsen, EI; Kalaitzakis, E	1
Lewin, JJ; Nappi, JM; Taylor, MH	1
Ceppa, P; Indiveri, F; Pelli, N; Setti, M; Toncini, C	1
Van Buuren, HR; Wolters, LM	1
Gibson, E; Luo, D; Newman, C; Szarek, M; Tsai, J	1
Baz, A; Clofent, J; de Castro, ML; de Luaces, C; Hermo, JA; Pérez, R	1
Blazing, M; Braunwald, E; Califf, R; Cannon, CP; de Lemos, JA; McCabe, CH; Murphy, SA; Wiviott, SD	1
Clarke, AT; Mills, PR	1
Becx, MC; Kuypers, KC; Seldenrijk, CA; Stolk, MF	1
Hey-Hadavi, JH; Kuntze, E; Lepetri, B; Luo, D; Pittman, D; Silverman, P	1
Guthrie, RM	1
Andrade, RJ; Barriocanal, A; Borraz, Y; Costa, J; Durán, JA; Fernández, MC; García-Cortés, M; García-Muņoz, B; Guarner, C; Hidalgo, R; Kaplowitz, N; Lucena, MI; Muņoz-Yagüe, T; Pachkoria, K; Pelaez, G; Planas, R; Rodrigo, L; Romero-Gomez, M; Salmerón, J	1
Alsheikh-Ali, AA; Karas, RH	1
Bataille, L; Hamoir, V; Horsmans, Y; Nakad, A; Sempoux, C	1
Crook, MA; Wierzbicki, AS	1

Reviews

9 review(s) available for atorvastatin and Chemical and Drug Induced Liver Injury

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical management of patients with drug-induced liver injury (DILI). United European gastroenterology journal, 2021, Volume: 9, Issue:7 Topics: Acetylcysteine; Aged; Anti-Bacterial Agents; Anticholesteremic Agents; Atorvastatin; Azithromycin; Checklist; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Middle Aged; Pruritus; Symptom Assessment	2021
Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of randomized trials with 94,283 participants. American heart journal, 2019, Volume: 210 Topics: Atorvastatin; Cardiovascular Diseases; Cause of Death; Chemical and Drug Induced Liver Injury; Double-Blind Method; Fluvastatin; Headache; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Lovastatin; Middle Aged; Muscular Diseases; Nausea; Neoplasms; Network Meta-Analysis; Placebos; Pravastatin; Randomized Controlled Trials as Topic; Risk Assessment; Rosuvastatin Calcium; Simvastatin; Withholding Treatment	2019
Hepatotoxicity of statins and other lipid-lowering agents. Liver international : official journal of the International Association for the Study of the Liver, 2017, Volume: 37, Issue:2 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin	2017
Drug-induced liver injury associated with statins. Seminars in liver disease, 2009, Volume: 29, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Autoimmunity; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Chronic Disease; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Liver; Liver Diseases; Male; Middle Aged; Practice Guidelines as Topic; Pyrroles; Risk Assessment; Treatment Outcome; Young Adult	2009
Comparative safety of atorvastatin 80 mg versus 10 mg derived from analysis of 49 completed trials in 14,236 patients. The American journal of cardiology, 2006, Jan-01, Volume: 97, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Albuminuria; Aspartate Aminotransferases; Atorvastatin; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Utilization; Female; Hematuria; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Muscular Diseases; Pain; Pyrroles; Retrospective Studies	2006
Atorvastatin associated liver disease. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2006, Volume: 38, Issue:10 Topics: Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Function Tests; Male; Middle Aged; Pyrroles	2006
Tolerability of atorvastatin in a population aged > or =65 years: a retrospective pooled analysis of results from fifty randomized clinical trials. The American journal of geriatric pharmacotherapy, 2006, Volume: 4, Issue:2 Topics: Aged; Anticholesteremic Agents; Atorvastatin; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Kidney Diseases; Male; Musculoskeletal Diseases; Pyrroles; Randomized Controlled Trials as Topic; Retrospective Studies	2006
How safe is aggressive statin therapy? Progress in cardiovascular nursing, 2006,Summer, Volume: 21, Issue:3 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Muscular Diseases; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2006

Trials

1 trial(s) available for atorvastatin and Chemical and Drug Induced Liver Injury

Article	Year
Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study. Clinical therapeutics, 2008, Volume: 30, Issue:12 Topics: Adult; Anticholesteremic Agents; Atorvastatin; C-Reactive Protein; Canada; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Europe; Female; Heptanoic Acids; Humans; Male; Prospective Studies; Pyrroles; Time Factors; Treatment Outcome; Triglycerides	2008

Article

Year

Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study.

Clinical therapeutics, 2008, Volume: 30, Issue:12

Topics: Adult; Anticholesteremic Agents; Atorvastatin; C-Reactive Protein; Canada; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Europe; Female; Heptanoic Acids; Humans; Male; Prospective Studies; Pyrroles; Time Factors; Treatment Outcome; Triglycerides

2008

Other Studies

47 other study(ies) available for atorvastatin and Chemical and Drug Induced Liver Injury

Article	Year
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with Journal of medicinal chemistry, 2008, May-08, Volume: 51, Issue:9 Topics: Administration, Oral; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Cholesterol; Crystallography, X-Ray; Dogs; Female; Guinea Pigs; Haplorhini; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Liver; Models, Molecular; Muscle Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazoles	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Hepatotoxicity in young adult rat offspring after prenatal exposure to benzo(a)pyrene, and protective effect of atorvastatin. Birth defects research, 2022, 07-01, Volume: 114, Issue:11 Topics: Animals; Antioxidants; Atorvastatin; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Female; Pregnancy; Prenatal Exposure Delayed Effects; Rats	2022
Atorvastatin-induced acute cholestatic hepatitis. Medicina clinica, 2022, 12-09, Volume: 159, Issue:11 Topics: Acute Disease; Atorvastatin; Chemical and Drug Induced Liver Injury; Cholestasis; Hepatitis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors	2022
[Case of hepatotoxicity of atorvastatin: the search for a possible etiology]. Tijdschrift voor gerontologie en geriatrie, 2022, May-30, Volume: 53, Issue:3 Topics: Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Rosuvastatin Calcium	2022
Astragaloside IV Alleviates Atorvastatin-Induced Hepatotoxicity via AMPK/SIRT1 Pathway. Pharmacology, 2023, Volume: 108, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Atorvastatin; Chemical and Drug Induced Liver Injury; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirtuin 1	2023
Therapeutic effects of atorvastatin on doxorubicin-induced hepatotoxicity in rats via antioxidative damage, anti-inflammatory, and anti-lipotoxicity. Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Atorvastatin; Chemical and Drug Induced Liver Injury; Doxorubicin; Drug-Related Side Effects and Adverse Reactions; Oxidative Stress; Rats	2023
[Statin-related drug-induced liver injury]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2023, Jun-20, Volume: 31, Issue:6 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin	2023
Atorvastatin Induces Hepatotoxicity in Diabetic Rats via Oxidative Stress, Inflammation, and Anti-Apoptotic Pathway. Medical science monitor : international medical journal of experimental and clinical research, 2019, Aug-17, Volume: 25 Topics: Animals; Antioxidants; Apoptosis; Atorvastatin; Blood Glucose; Chemical and Drug Induced Liver Injury; China; Diabetes Mellitus, Experimental; Hepatocytes; Inflammation; Liver; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase	2019
An unusually impressive atorvastatin-induced elevation of serum alkaline phosphatase. BMJ case reports, 2020, Feb-10, Volume: 13, Issue:2 Topics: Aged, 80 and over; Alkaline Phosphatase; Atorvastatin; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Humans	2020
Hepatoprotective effect of atorvastatin on Cadmium chloride induced hepatotoxicity in rats. Life sciences, 2020, Aug-01, Volume: 254 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Atorvastatin; Cadmium; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase	2020
Dietary Cholesterol Exacerbates Statin-Induced Hepatic Toxicity in Syrian Golden Hamsters and in Patients in an Observational Cohort Study. Cardiovascular drugs and therapy, 2021, Volume: 35, Issue:2 Topics: Animals; Atorvastatin; Chemical and Drug Induced Liver Injury; Cholesterol, Dietary; Cricetinae; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Rosuvastatin Calcium	2021
Optimization of transdermal atorvastatin calcium - Loaded proniosomes: Restoring lipid profile and alleviating hepatotoxicity in poloxamer 407-induced hyperlipidemia. International journal of pharmaceutics, 2021, Jan-25, Volume: 593 Topics: Administration, Cutaneous; Animals; Atorvastatin; Biological Availability; Chemical and Drug Induced Liver Injury; Hyperlipidemias; Poloxamer; Rats; Skin Absorption	2021
Co-administration of CSL112 (apolipoprotein A-I [human]) with atorvastatin and alirocumab is not associated with increased hepatotoxic or toxicokinetic effects in rats. Toxicology and applied pharmacology, 2021, 07-01, Volume: 422 Topics: Animals; Antibodies, Monoclonal, Humanized; Anticholesteremic Agents; Atorvastatin; Biomarkers; Chemical and Drug Induced Liver Injury; Cholesterol; Drug Interactions; Female; Lipoproteins, HDL; Liver; Male; Rats, Sprague-Dawley; Risk Assessment; Toxicity Tests; Toxicokinetics	2021
An unwanted complement: Rare case of potential liver injury induced by an interaction between ginseng and atorvastatin. British journal of clinical pharmacology, 2019, Volume: 85, Issue:7 Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Fermented Foods; Healthy Volunteers; Humans; Liver; Panax	2019
Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death. The American journal of case reports, 2019, May-18, Volume: 20 Topics: Acute Kidney Injury; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Fatal Outcome; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rhabdomyolysis	2019
Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin. Internal medicine (Tokyo, Japan), 2019, Sep-15, Volume: 58, Issue:18 Topics: Adult; Atorvastatin; Autoantibodies; Chemical and Drug Induced Liver Injury; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria	2019
Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Atorvastatin; Chemical and Drug Induced Liver Injury; Down-Regulation; Doxorubicin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Male; Nitric Oxide; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Up-Regulation	2014
[Rhabdomyolysis and severe hepatotoxicity due to a drug-drug interaction between ritonavir and simvastatin. Could we use the most cost-effective statin in all human immunodeficiency virus-infected patients?]. Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32, Issue:9 Topics: Antiretroviral Therapy, Highly Active; Atorvastatin; Chemical and Drug Induced Liver Injury; Comorbidity; Contraindications; Cost-Benefit Analysis; Cytochrome P-450 CYP3A Inhibitors; Drug Substitution; Drug Synergism; Dyslipidemias; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubular Necrosis, Acute; Middle Aged; Rhabdomyolysis; Ritonavir; Simvastatin	2014
Severe hepatic injury associated with different statins in patients with chronic liver disease: a nationwide population-based cohort study. Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:1 Topics: Adult; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Chronic Disease; Cohort Studies; Follow-Up Studies; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Liver Diseases; Male; Middle Aged; Pyrroles; Risk; Severity of Illness Index; Taiwan; Time Factors	2015
Acute liver failure following atorvastatin dose escalation: is there a threshold dose for idiosyncratic hepatotoxicity? Journal of hepatology, 2015, Volume: 62, Issue:3 Topics: Aged, 80 and over; Atorvastatin; Chemical and Drug Induced Liver Injury; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Failure, Acute	2015
Protective effect of arjunolic acid against atorvastatin induced hepatic and renal pathophysiology via MAPK, mitochondria and ER dependent pathways. Biochimie, 2015, Volume: 112 Topics: Animals; Apoptosis; Atorvastatin; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Diseases; Liver; Male; MAP Kinase Signaling System; Mice; Mitochondria, Liver; Oxidative Stress; Triterpenes	2015
[Liver damage caused by atorvastatin and cyclosporine in patients with renal transplant]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2014, Volume: 68, Issue:2 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Cyclosporine; Graft Rejection; Graft Survival; Heptanoic Acids; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Liver; Male; Middle Aged; Pyrroles	2014
Atorvastatin induced hepatic oxidative stress and apoptotic damage via MAPKs, mitochondria, calpain and caspase12 dependent pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 83 Topics: Animals; Apoptosis; Atorvastatin; Biomarkers; Calcium Signaling; Calpain; Caspase 12; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Male; MAP Kinase Signaling System; Mice; Mitochondria, Liver; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Random Allocation; Reactive Oxygen Species; Survival Analysis	2015
A Systematic Strategy for Screening and Application of Specific Biomarkers in Hepatotoxicity Using Metabolomics Combined With ROC Curves and SVMs. Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 150, Issue:2 Topics: Acetaminophen; Animals; Atorvastatin; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Liver; Male; Metabolomics; Rats, Wistar; ROC Curve; Sensitivity and Specificity; Support Vector Machine	2016
ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population. BMC genetics, 2016, 06-13, Volume: 17, Issue:1 Topics: Asian People; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Cell Line; Chemical and Drug Induced Liver Injury; Genetic Predisposition to Disease; Humans; Japan; Polymorphism, Single Nucleotide	2016
Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice. PloS one, 2016, Volume: 11, Issue:7 Topics: Animals; Apolipoproteins E; Atorvastatin; Caseins; Catalase; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Inflammation; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase	2016
[Association between statins use and liver injury based on prescription sequence symmetry analysis]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2016, Volume: 37, Issue:7 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Prescription Drugs; Simvastatin	2016
The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1. Scientific reports, 2016, 09-14, Volume: 6 Topics: Animals; Atorvastatin; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Hepatocytes; Liver-Specific Organic Anion Transporter 1; Male; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Up-Regulation	2016
Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:2 Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atorvastatin; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Hepatic Stellate Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Infusion Pumps, Implantable; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Transforming Growth Factor beta1	2009
Cholestatic jaundice induced by atorvastatin: a possible association with antimitochondrial antibodies. The Israel Medical Association journal : IMAJ, 2009, Volume: 11, Issue:7 Topics: Aged; Atorvastatin; Autoantibodies; Chemical and Drug Induced Liver Injury; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Jaundice, Obstructive; Male; Mitochondria; Pyrroles	2009
Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Dec-01, Volume: 17, Issue:14 Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Atorvastatin; Catalase; Chemical and Drug Induced Liver Injury; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Heptanoic Acids; Liver; Male; Malondialdehyde; Nitric Oxide; Phytotherapy; Plant Extracts; Pyrroles; Random Allocation; Rats; Rats, Wistar; Rhizome; Superoxide Dismutase; Transaminases; Vitamin E; Zingiber officinale	2010
Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis. Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Atorvastatin; Bacteremia; Chemical and Drug Induced Liver Injury; Cricetinae; Cytokines; Dose-Response Relationship, Drug; Fluorouracil; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukopenia; Male; Mesocricetus; Mouth Mucosa; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Pyrroles; Stomatitis; Sulfhydryl Compounds	2011
[Liver damage in a patient treated with a vitamin K antagonist, a statin and an ACE inhibitor]. Praxis, 2010, Oct-20, Volume: 99, Issue:21 Topics: Administration, Oral; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Atorvastatin; Biopsy; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Therapy, Combination; Hematuria; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Function Tests; Male; Perindopril; Phenprocoumon; Pyrroles; Vitamin K	2010
Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. Journal of hepatology, 2012, Volume: 56, Issue:2 Topics: Adverse Drug Reaction Reporting Systems; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles; Simvastatin; Sweden; Time Factors	2012
Rhabdomyolysis with concurrent atorvastatin and diltiazem. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10 Topics: Acute Disease; Acute Kidney Injury; Atorvastatin; Cardiovascular Agents; Chemical and Drug Induced Liver Injury; Diltiazem; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles; Rhabdomyolysis	2002
Autoimmune hepatitis revealed by atorvastatin. European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:8 Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Atorvastatin; Autoimmune Diseases; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Function Tests; Pyrroles	2003
Rosuvastatin-associated hepatitis with autoimmune features. European journal of gastroenterology & hepatology, 2005, Volume: 17, Issue:5 Topics: Anticholesteremic Agents; Atorvastatin; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Middle Aged; Pyrroles	2005
[Acute cholestatic hepatitis after atorvastatin reintroduction]. Gastroenterologia y hepatologia, 2006, Volume: 29, Issue:1 Topics: Acute Disease; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Cholestasis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pyrroles	2006
A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22. Circulation, 2006, Mar-21, Volume: 113, Issue:11 Topics: Aged; Angina, Unstable; Atorvastatin; C-Reactive Protein; Cardiovascular Diseases; Case Management; Chemical and Drug Induced Liver Injury; Comorbidity; Confounding Factors, Epidemiologic; Dose-Response Relationship, Drug; Endpoint Determination; Female; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Life Tables; Lipids; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascularization; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk; Risk Factors; Simvastatin; Stroke; Tirofiban; Treatment Outcome; Tyrosine	2006
Severe hepatic side effects of ezetimibe. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:7 Topics: Anticholesteremic Agents; Atorvastatin; Azetidines; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Ezetimibe; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Liver Diseases; Male; Middle Aged; Pyrroles; Transaminases	2006
Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Atorvastatin; Azepines; Captopril; Cardiovascular Agents; Central Nervous System Agents; Chemical and Drug Induced Liver Injury; Chronic Disease; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Heptanoic Acids; Humans; Liver; Liver Diseases; Male; Middle Aged; Pyrroles; Registries; Spain	2006
Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system). The American journal of cardiology, 2007, Feb-01, Volume: 99, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Drug Therapy, Combination; Dyslipidemias; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver Diseases; Lovastatin; Niacin; Pravastatin; Prevalence; Pyrroles; Retrospective Studies; Rhabdomyolysis; Risk Factors; Simvastatin; United States; United States Food and Drug Administration	2007
Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin. Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166 Topics: Aged; Anticholesteremic Agents; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Pyrroles; Simvastatin	1999
Cholestatic liver dysfunction. Lancet (London, England), 1999, Sep-11, Volume: 354, Issue:9182 Topics: Anticholesteremic Agents; Atorvastatin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diagnosis, Differential; Heptanoic Acids; Humans; Liver Function Tests; Male; Middle Aged; Pyrroles	1999