Page last updated: 2024-08-24

atorvastatin and Cerebral Hemorrhage

atorvastatin has been researched along with Cerebral Hemorrhage in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (37.14)29.6817
2010's15 (42.86)24.3611
2020's7 (20.00)2.80

Authors

AuthorsStudies
Chen, C; Chen, D; Guan, J; Liu, S; Sui, L; Sun, X1
Li, X; Yang, Q; Yang, Y1
Chen, H; Hu, Y; Qin, X; Wang, M; Wang, S; Wu, J; Wu, T; Wu, Y; Yang, R; Yu, H1
Chen, K; Lan, S; Liao, G; Luo, H; Xie, Z; Xu, J; Xu, S; Yang, X1
Chen, WF; He, SP; Hong, MP; Kang, TS; Wu, JH; Yang, QW1
Gong, X; Li, J; Lou, M; Luo, Z; Sun, J; Yan, S; Zhao, Y; Zhou, H; Zhou, Y1
Spence, JD1
Hoi, MPM; Huang, B; Huang, XH; Lee, SMY; Li, S; Tang, JY; Zhou, ZY1
Auger, F; Barus, R; Bergeron, S; Bordet, R; Chen, Y; Cordonnier, C; Deguil, J; Durieux, N; Gautier, S; Pasquier, F; Potey, C; Ravasi, L; Skrobala, E1
Jayakrishnan, C; Karadan, U; Manappallil, RG; Supreeth, RN1
Hoi, PM; Huang, B; Huang, XH; Kwan, YW; Lee, SM; Li, S; Tang, JY; Zhou, ZY1
Allan, SM; Badrock, AP; Barrington, J; Crilly, S; Fotiou, E; Hudson, G; Hurlstone, A; Kasher, PR; Laurie, SE; Njegic, A; Parry-Jones, AR; Rivers-Auty, J; Webb, K; Young, HL1
Akers, AL; Awad, IA; Cao, Y; Christoforidis, GA; Fam, MD; Flemming, KD; Girard, R; Hanley, DF; Hobson, N; Koenig, JI; Koskimäki, J; Lane, K; Lee, C; Liao, JK; Lyne, SB; McBee, N; Morrison, L; Piedad, K; Polster, SP; Shenkar, R; Sorrentino, M; Stadnik, A; Thompson, RE; Whitehead, KJ; Zeineddine, HA1
Hou, T; Lee, SM; Li, P; Li, S; Li, Y; Pan, P; Shen, M; Yu, H; Zhang, L; Zhou, S1
Dippel, DW; Scheele, M; van den Meiracker, AH; Versmissen, J1
Chen, Y; Geng, J; Li, Y; Lin, Y; Mu, Z; Pan, Y; Shi, G; Song, Y; Sun, Y; Xu, Q; Yang, GY; Yu, L1
Hou, T; Lee, SM; Li, C; Li, D; Li, Y; Pan, P; Shen, M; Sun, H; Tian, S; Zhou, H1
Fatar, M; Grudzenski, S; Heiler, P; Hennerici, MG; Reuter, B; Schad, L; Staufenbiel, M; Venus, A1
Fitchett, DH; Goodman, SG; Langer, A1
Amarenco, P; Callahan, A; Goldstein, LB; Hennerici, MG; Messig, M; Sillesen, H; Welch, KM; Zivin, J1
Amarenco, P; Benavente, O; Callahan, A; Gilbert, S; Goldstein, LB; Hennerici, MG; Rudolph, AE; Sillesen, H; Simunovic, L; Welch, KM; Zivin, JA1
Goldstein, MR; Mascitelli, L; Pezzetta, F1
El-Remessy, AB; Elewa, HF; Ergul, A; Fagan, SC; Frye, RF; Johnson, MH; Kozak, A1
Chaturvedi, S; Goldstein, MR; Mascitelli, L; Pezzetta, F1
Chopp, M; Han, Y; Karki, K; Knight, RA; Ledbetter, KA; Seyfried, DM; Yang, D; Zhang, J1
Chopp, M; Ding, C; Han, Y; Karki, K; Knight, RA; Seyfried, DM; Yang, D; Zhang, J1
Cui, JJ; Gao, F; Li, YR; Wang, D1
Chaogang, T; Ewen, T; Guanghong, X; Jun, W; Liming, T; Qiuting, L; Tao, T1
Eisa-Beygi, S; Ekker, M; Hatch, G; Moon, TW; Noble, S1
Alexy, T; Czopf, J; Habon, T; Horvath, B; Juricskay, I; Kesmarky, G; Koltai, K; Marton, Z; Szapary, L; Szots, M; Toth, K1
Chu, K; Han, SY; Jeong, SW; Jung, KH; Kim, JY; Kim, M; Lee, ST; Roh, JK1
Bydon, A; Chen, J; Chopp, M; Han, Y; Lu, D; Seyfried, D1
Amarenco, P; Bogousslavsky, J; Callahan, A; Goldstein, LB; Hennerici, M; Rudolph, AE; Sillesen, H; Simunovic, L; Szarek, M; Welch, KM; Zivin, JA1
Cohen, JS1
Karam, JG; Loney-Hutchinson, L; McFarlane, SI1

Reviews

1 review(s) available for atorvastatin and Cerebral Hemorrhage

ArticleYear
[Statins after intracerebral haemorrhage: is this safe?].
    Nederlands tijdschrift voor geneeskunde, 2015, Volume: 159

    Topics: Atorvastatin; Cerebral Hemorrhage; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Stroke

2015

Trials

3 trial(s) available for atorvastatin and Cerebral Hemorrhage

ArticleYear
Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
    Neurosurgery, 2019, 12-01, Volume: 85, Issue:6

    Topics: Atorvastatin; Cerebral Hemorrhage; Double-Blind Method; Female; Follow-Up Studies; Hemangioma, Cavernous; Hemangioma, Cavernous, Central Nervous System; Humans; Magnetic Resonance Imaging; Male; Proof of Concept Study; Prospective Studies; Protein Kinase Inhibitors; rhoA GTP-Binding Protein; Treatment Outcome

2019
Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial by stroke subtypes.
    Stroke, 2009, Volume: 40, Issue:4

    Topics: Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Placebos; Proportional Hazards Models; Pyrroles; Risk Factors; Stroke; Treatment Outcome

2009
High-dose atorvastatin after stroke or transient ischemic attack.
    The New England journal of medicine, 2006, 08-10, Volume: 355, Issue:6

    Topics: Adult; Atorvastatin; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebral Infarction; Cholesterol, LDL; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Male; Proportional Hazards Models; Pyrroles; Risk; Secondary Prevention; Stroke

2006

Other Studies

31 other study(ies) available for atorvastatin and Cerebral Hemorrhage

ArticleYear
Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways.
    Aging, 2022, 01-11, Volume: 14, Issue:1

    Topics: Animals; Atorvastatin; Cerebral Hemorrhage; Cytokines; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Toll-Like Receptor 4

2022
Related Factors of Cerebral Hemorrhage after Cerebral Infarction and the Effect of Atorvastatin Combined with Intensive Nursing Care.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Adult; Atorvastatin; Atrial Fibrillation; Case-Control Studies; Cerebral Hemorrhage; Cerebral Infarction; Humans; Hypertension; Retrospective Studies; Stroke; Tablets

2022
Is statin therapy after ischaemic stroke associated with increased intracerebral hemorrhage? The association may be dependent on intensity of statin therapy.
    International journal of stroke : official journal of the International Stroke Society, 2023, Volume: 18, Issue:8

    Topics: Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Stroke; Rosuvastatin Calcium; Simvastatin; Stroke

2023
The L-shaped correlation between systolic blood pressure and short-term and long-term mortality in patients with cerebral hemorrhage.
    BMC neurology, 2023, Jun-14, Volume: 23, Issue:1

    Topics: Atorvastatin; Blood Pressure; Cefdinir; Cerebral Hemorrhage; Cerebral Infarction; Humans; Hypertension; Hypotension

2023
Correlation between lipid-lowering therapy and cerebral microbleeds.
    Clinical hemorheology and microcirculation, 2023, Volume: 85, Issue:1

    Topics: Atorvastatin; Cerebral Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnetic Resonance Imaging; Retrospective Studies; Risk Factors; Rosuvastatin Calcium

2023
Low-density lipoprotein cholesterol, statin therapy, and cerebral microbleeds: The CIRCLE study.
    NeuroImage. Clinical, 2023, Volume: 39

    Topics: Atorvastatin; Cerebral Hemorrhage; Cerebral Small Vessel Diseases; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Stroke

2023
Intracerebral Hemorrhage in SPARCL: What Was the Relationship to LDL-C?
    Journal of the American College of Cardiology, 2020, 08-18, Volume: 76, Issue:7

    Topics: Atorvastatin; Cerebral Hemorrhage; Cholesterol, LDL; Humans; Stroke

2020
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility.
    Pharmacological research, 2018, Volume: 128

    Topics: Abietanes; Actins; Animals; Animals, Genetically Modified; Antigens, CD; Atorvastatin; Cadherins; Cell Adhesion; Cerebral Hemorrhage; Embryo, Nonmammalian; Human Umbilical Vein Endothelial Cells; Humans; Myosins; Protective Agents; Zebrafish

2018
Role of cortical microbleeds in cognitive impairment: In vivo behavioral and imaging characterization of a novel murine model.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:6

    Topics: Animals; Atorvastatin; Brain; Cerebral Hemorrhage; Cognitive Dysfunction; Collagenases; Disease Models, Animal; Male; Mice; Positron Emission Tomography Computed Tomography

2019
Pontine haemorrhage disguised as Bell's palsy.
    BMJ case reports, 2018, Feb-05, Volume: 2018

    Topics: Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Atorvastatin; Bell Palsy; Cerebral Hemorrhage; Diagnosis, Differential; Diuretics, Osmotic; Facial Paralysis; Humans; Magnetic Resonance Imaging; Male; Mannitol; Middle Aged; Neural Pathways; Perindopril; Physical Therapy Modalities; Pons; Treatment Outcome

2018
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish.
    Toxicology and applied pharmacology, 2018, 07-01, Volume: 350

    Topics: Animals; Animals, Genetically Modified; Antigens, CD; Atorvastatin; Cadherins; Cell Survival; Cerebral Hemorrhage; Dose-Response Relationship, Drug; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Phenanthrenes; rho-Associated Kinases; rhoA GTP-Binding Protein; Zebrafish

2018
Using zebrafish larval models to study brain injury, locomotor and neuroinflammatory outcomes following intracerebral haemorrhage.
    F1000Research, 2018, Volume: 7

    Topics: Animals; Atorvastatin; Brain; Brain Injuries; Cerebral Hemorrhage; Disease Models, Animal; Immunity, Innate; Inflammation; Larva; Locomotion; Macrophage Activation; Mutation; Phagocytosis; Phenotype; Zebrafish

2018
Discovery of Rho-kinase inhibitors by docking-based virtual screening.
    Molecular bioSystems, 2013, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Cerebral Hemorrhage; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Female; HeLa Cells; Heptanoic Acids; Humans; Lung Neoplasms; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Multiple Myeloma; Protein Kinase Inhibitors; Pyrroles; rho-Associated Kinases; Zebrafish

2013
Early Use of Statin in Patients Treated with Alteplase for Acute Ischemic Stroke.
    Acta neurochirurgica. Supplement, 2016, Volume: 121

    Topics: Aged; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Early Medical Intervention; Female; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Risk Factors; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Treatment Outcome

2016
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays.
    Scientific reports, 2015, Nov-16, Volume: 5

    Topics: Actin Depolymerizing Factors; Amides; Animals; Atorvastatin; Binding Sites; Cerebral Hemorrhage; Databases, Chemical; Databases, Protein; Disease Models, Animal; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyridines; Pyrroles; rho-Associated Kinases; Signal Transduction; Structure-Activity Relationship; Zebrafish

2015
Statin Therapy and the Development of Cerebral Amyloid Angiopathy--A Rodent in Vivo Approach.
    International journal of molecular sciences, 2016, Jan-19, Volume: 17, Issue:1

    Topics: Amyloid beta-Protein Precursor; Animals; Anticholesteremic Agents; Atorvastatin; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Disease Models, Animal; Gene Expression; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Transgenic

2016
Ischemic stroke: a cardiovascular risk equivalent? Lessons learned from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.
    The Canadian journal of cardiology, 2008, Volume: 24, Issue:9

    Topics: Atorvastatin; Cardiovascular Diseases; Cerebral Hemorrhage; Cholesterol; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Pyrroles; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke

2008
Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.
    Stroke, 2008, Volume: 39, Issue:12

    Topics: Aged; Atorvastatin; Brain Ischemia; Carotid Stenosis; Cerebral Hemorrhage; Cholesterol, LDL; Coronary Disease; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ischemic Attack, Transient; Male; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic; Recurrence; Risk; Treatment Outcome

2008
Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study.
    Neurology, 2009, Apr-21, Volume: 72, Issue:16

    Topics: Age Factors; Aged; Atorvastatin; Causality; Cerebral Hemorrhage; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Iatrogenic Disease; Intracranial Arteriosclerosis; Male; Pyrroles; Sex Factors

2009
Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:2

    Topics: Acute Disease; Animals; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Diabetes Mellitus, Type 2; Drug Administration Schedule; Heptanoic Acids; Male; Pyrroles; Rats; Rats, Wistar; Time Factors

2009
Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack.
    Neurology, 2009, Jul-21, Volume: 73, Issue:3

    Topics: Age Distribution; Age Factors; Aged; Anticholesteremic Agents; Atorvastatin; Cerebral Hemorrhage; Cholesterol, LDL; Clinical Trials as Topic; Heptanoic Acids; Humans; Iatrogenic Disease; Ischemic Attack, Transient; Pyrroles; Risk Assessment; Risk Factors; Stroke

2009
Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage.
    Stroke, 2009, Volume: 40, Issue:10

    Topics: Animals; Apoptosis; Atorvastatin; Biomarkers; Brain; Brain Infarction; Bromodeoxyuridine; Cerebral Hemorrhage; Cytoprotection; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Microtubule-Associated Proteins; Nerve Degeneration; Neurogenesis; Neuronal Plasticity; Neuropeptides; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Regeneration; Simvastatin; Treatment Outcome

2009
Vascular recovery promoted by atorvastatin and simvastatin after experimental intracerebral hemorrhage: magnetic resonance imaging and histological study.
    Journal of neurosurgery, 2011, Volume: 114, Issue:4

    Topics: Animals; Atorvastatin; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Cerebrovascular Circulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Magnetic Resonance Imaging; Neovascularization, Physiologic; Nerve Regeneration; Pyrroles; Rats; Rats, Wistar; Simvastatin

2011
Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage.
    Cell biochemistry and biophysics, 2012, Volume: 62, Issue:1

    Topics: Animals; Atorvastatin; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Water

2012
Neuroprotective effect of atorvastatin involves suppression of TNF-α and upregulation of IL-10 in a rat model of intracerebral hemorrhage.
    Cell biochemistry and biophysics, 2013, Volume: 66, Issue:2

    Topics: Animals; Atorvastatin; Behavior, Animal; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Heptanoic Acids; Interleukin-10; Male; Microglia; Neuroprotective Agents; Pyrroles; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Up-Regulation

2013
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway.
    Developmental biology, 2013, Jan-15, Volume: 373, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Atorvastatin; cdc42 GTP-Binding Protein; Cerebral Hemorrhage; Cerebrum; Embryo, Nonmammalian; Endothelial Cells; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Morpholinos; Polyisoprenyl Phosphates; Prenylation; Pyrroles; rhoA GTP-Binding Protein; Signal Transduction; Zebrafish

2013
Short-term effect of low-dose atorvastatin on haemorrheological parameters, platelet aggregation and endothelial function in patients with cerebrovascular disease and hyperlipidaemia.
    CNS drugs, 2004, Volume: 18, Issue:3

    Topics: Aged; Atorvastatin; Cerebral Hemorrhage; Cerebrovascular Disorders; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hyperlipidemias; Male; Middle Aged; Platelet Aggregation; Pyrroles; Time Factors

2004
HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage.
    Stroke, 2004, Volume: 35, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Atrophy; Brain; Cell Death; Cerebral Hemorrhage; Hematoma; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Models, Animal; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Psychomotor Performance; Pyrroles; Rats; Rats, Sprague-Dawley

2004
Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats.
    Journal of neurosurgery, 2004, Volume: 101, Issue:1

    Topics: Animals; Atorvastatin; Brain; Cerebral Hemorrhage; Disease Models, Animal; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nervous System; Pyrroles; Rats; Rats, Wistar; Recovery of Function; Severity of Illness Index; Treatment Outcome

2004
Statin therapy after stroke or transient ischemic attack.
    The New England journal of medicine, 2006, Nov-30, Volume: 355, Issue:22

    Topics: Atorvastatin; Cardiovascular Diseases; Cerebral Hemorrhage; Cholesterol, LDL; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Risk Factors; Stroke; Transaminases

2006
High-dose atorvastatin after stroke or transient ischemic attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators.
    Journal of the cardiometabolic syndrome, 2008,Winter, Volume: 3, Issue:1

    Topics: Adult; Atorvastatin; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebral Infarction; Cholesterol, LDL; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Male; Pyrroles; Randomized Controlled Trials as Topic; Recurrence; Risk; Stroke

2008