Compounds > atorvastatin
Page last updated: 2024-08-24

atorvastatin and Breast Neoplasms

atorvastatin has been researched along with Breast Neoplasms in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.13)18.2507
2000's3 (9.38)29.6817
2010's22 (68.75)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF1
Abolghasemi, R; Ai, J; Bahrami, N; Ebrahimi-Barough, S1
Kida, M; Koshizuka, H; Kuchira, R; Momo, K; Morita, M; Nishimura, K; Sasaki, T; Tanaka, K; Watanabe, A; Yamamoto, M1
Anghel, R; Forsea, L; Gales, L; Georgescu, M; Mitrea, D; Mitrica, R; Serbanescu, L; Stanculescu, I; Stefanica, I; Trifanescu, O1
Abdel-Qadir, H; Amir, E; Billia, F; Brezden-Masley, C; Chan, J; Connelly, KA; Hanneman, K; Houbois, C; Huang, F; Kei, T; Marwick, TH; Maze, D; Pezo, RC; Power, C; Prica, A; Runeckles, K; Saha, S; Shalmon, T; Thavendiranathan, P; Thorpe, KE; Wintersperger, BJ1
Akimov, MG; Bezuglov, VV; Dudina, PV; Gamisonia, AM; Gretskaya, NM; Mandal, CC; Zinchenko, GN1
Alarcon Martinez, T; Müftüoğlu, S; Zeybek, ND1
Borgquist, S; Inasu, M; Kimbung, S; Lettiero, B1
Alimohammadi, N; Danafar, H; Hamidreza Kheiri, M1
Gambhire, MS; Gambhire, VM; Salunkhe, SM1
Akbari, J; Ghasemi, A; Ghashghai, Z; Hosseinimehr, SJ; Salehifar, E; Yazdani-Charati, J1
Beckwitt, CH; Clark, AM; Ma, B; Oltvai, ZN; Wells, A; Whaley, D1
Gao, J; Gao, Y; He, X; He, Y; Li, K; Liu, S; Ma, Q; Pan, W; Qi, Y; Song, W; Wei, L; Xu, J; Xu, P; Xu, X; Yang, Y; Yin, W; Yuan, X; Zhang, J1
Bendahl, PO; Bjarnadottir, O; Borgquist, S; Grabau, D; Jirström, K; Johannesson, H; Loman, N; Romero, Q; Rose, C; Rydén, L; Uhlén, M1
Hou, T; Lee, SM; Li, P; Li, S; Li, Y; Pan, P; Shen, M; Yu, H; Zhang, L; Zhou, S1
Chen, X; Li, Y; Meng, Q; Sun, H; Xu, P; Yin, Q; Yu, H; Zhang, Z1
Hyder, SM; Liang, Y; Mafuvadze, B1
Berlot, CH; Childress, C; Lin, Q; Mi, W; Robishaw, J; Shabahang, M; Sudol, M; Yang, W1
Bendahl, PO; Bjarnadottir, O; Borgquist, S; Grabau, D; Hedenfalk, I; Johansson, I; Jönsson, M; Kimbung, S; Veerla, S1
Browne, AJ; Göbel, A; Hofbauer, LC; Rachner, TD; Rauner, M; Thiele, S1
Crocker, A; Garber, JE; Hovey, RC; Ji, Y; Kingsley, F; Muss, HB; Rounds, T; Sussman, B; Wood, ME1
Browne, AJ; Göbel, A; Hofbauer, LC; Rachner, TD; Rauner, M; Thiele, S; Zinna, VM1
Alvarez, RR; Arun, BK; Brown, P; Cornelison, T; Gong, Y; Gutierrez-Barrera, AM; Heckman-Stoddard, BM; Hortobagyi, GN; Ibrahim, NK; Jack Lee, J; Koenig, KB; Lippman, SM; Litton, JK; Liu, D; Murray, JL; Sneige, N; Valero, V; Vornik, L1
Borgquist, S; Bosch, A; Feldt, M; Kimbung, S; Lettiero, B1
Deng, L; Ding, Y; Fan, J; Huang, B; Peng, Y1
Lóopez-Marure, R; Massó, FA; Montaño, LF; Páez, A; Rodríguez, E; Sánchez, CA; Varela, E; Zapata, E1
Handal, J; Kwok, SC; Samuel, SP1
Boerner, JL; Bohin, N; Ge, Y; Irwin, ME; Mueller, KL1
Anderson, L; Bhattacharya, S; Bose, N; Fraser, E; Graham, K; Lumsden, G; McClue, L; Robertson, L; Tho, LM; Yosef, H1
Mück, AO; Seeger, H; Wallwiener, D1
Jonkers, GH1
Lupattelli, G; Palumbo, B; Sinzinger, H1

Reviews

2 review(s) available for atorvastatin and Breast Neoplasms

ArticleYear
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells

2022
Antidiabetics, Anthelmintics, Statins, and Beta-Blockers as Co-Adjuvant Drugs in Cancer Therapy.
    Medicina (Kaunas, Lithuania), 2022, Sep-07, Volume: 58, Issue:9

    Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Anthelmintics; Anti-Bacterial Agents; Antihypertensive Agents; Antimalarials; Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Cholesterol; Diabetes Mellitus, Type 2; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Mebendazole; Metformin; Mevalonic Acid; Propranolol; Protein Kinases; Proto-Oncogene Proteins B-raf; Receptors, Adrenergic, beta-2; Tyrosine

2022

Trials

6 trial(s) available for atorvastatin and Breast Neoplasms

ArticleYear
Statins to prevent early cardiac dysfunction in cancer patients at increased cardiotoxicity risk receiving anthracyclines.
    European heart journal. Cardiovascular pharmacotherapy, 2023, 09-20, Volume: 9, Issue:6

    Topics: Anthracyclines; Antibiotics, Antineoplastic; Atorvastatin; Biomarkers; Breast Neoplasms; Cardiotoxicity; Female; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Stroke Volume; Ventricular Function, Left

2023
Topical atorvastatin 1% for prevention of skin toxicity in patients receiving radiation therapy for breast cancer: a randomized, double-blind, placebo-controlled trial.
    European journal of clinical pharmacology, 2019, Volume: 75, Issue:2

    Topics: Administration, Topical; Atorvastatin; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Radiodermatitis; Skin

2019
Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial.
    Breast cancer research and treatment, 2013, Volume: 138, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Atorvastatin; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Combined Modality Therapy; Female; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ki-67 Antigen; Middle Aged; Pyrroles; Treatment Outcome

2013
Global Transcriptional Changes Following Statin Treatment in Breast Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Aug-01, Volume: 21, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Microarray Analysis; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Proteins; Signal Transduction; Transcriptome

2015
The Effect of Atorvastatin on Breast Cancer Biomarkers in High-Risk Women.
    Cancer prevention research (Philadelphia, Pa.), 2016, Volume: 9, Issue:5

    Topics: Adult; Atorvastatin; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Premenopause; Risk Factors

2016
Phase I biomarker modulation study of atorvastatin in women at increased risk for breast cancer.
    Breast cancer research and treatment, 2016, Volume: 158, Issue:1

    Topics: Adult; Aged; Atorvastatin; Biomarkers, Tumor; Biopsy, Fine-Needle; Breast Neoplasms; C-Reactive Protein; Cholesterol; Drug Administration Schedule; Female; Humans; Lipoproteins, LDL; Middle Aged; Prospective Studies; Treatment Outcome

2016

Other Studies

24 other study(ies) available for atorvastatin and Breast Neoplasms

ArticleYear
Atorvastatin Inhibits Viability and Migration of MCF7 Breast Cancer Cells.
    Asian Pacific journal of cancer prevention : APJCP, 2022, Mar-01, Volume: 23, Issue:3

    Topics: Apoptosis; Atorvastatin; Breast Neoplasms; Cell Movement; Female; Humans; MCF-7 Cells

2022
Drug-drug interaction between apalutamide and atorvastatin through breast cancer resistance protein in an outpatient.
    International journal of clinical pharmacology and therapeutics, 2022, Volume: 60, Issue:8

    Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Interactions; Female; Humans; Neoplasm Proteins; Outpatients; Thiohydantoins

2022
The Influence of the Cholesterol Level in Cells on Endovanilloid Cytotoxicity.
    Doklady. Biochemistry and biophysics, 2020, Volume: 493, Issue:1

    Topics: Anticholesteremic Agents; Apoptosis; Atorvastatin; Breast Neoplasms; Cholesterol; Dopamine; Female; Humans; Receptors, Cannabinoid; Tumor Cells, Cultured

2020
Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells
    Balkan medical journal, 2018, May-29, Volume: 35, Issue:3

    Topics: Apoptosis; Atorvastatin; Autophagy; Breast Neoplasms; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells

2018
Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells.
    Scientific reports, 2018, 04-03, Volume: 8, Issue:1

    Topics: Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Fatty Acids; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Droplets

2018
Preparation of biocompatible copolymeric micelles as a carrier of atorvastatin and rosuvastatin for potential anticancer activity study.
    Pharmaceutical development and technology, 2019, Volume: 24, Issue:3

    Topics: Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Cell Survival; Chemistry, Pharmaceutical; Drug Carriers; Drug Liberation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MCF-7 Cells; Micelles; Nanoparticles; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Rosuvastatin Calcium

2019
Atorvastatin-loaded lipid nanoparticles: antitumor activity studies on MCF-7 breast cancer cells.
    Drug development and industrial pharmacy, 2018, Volume: 44, Issue:10

    Topics: Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Drug Carriers; Female; Humans; Lipids; MCF-7 Cells; Nanoparticles; Particle Size

2018
Statins attenuate outgrowth of breast cancer metastases.
    British journal of cancer, 2018, Volume: 119, Issue:9

    Topics: Animals; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coculture Techniques; Epithelial-Mesenchymal Transition; Female; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms; Lung Neoplasms; MCF-7 Cells; Mice; Xenograft Model Antitumor Assays

2018
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Recurrence, Local; Prognosis; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; rhoB GTP-Binding Protein; Signal Transduction; Up-Regulation; Xenograft Model Antitumor Assays

2019
Discovery of Rho-kinase inhibitors by docking-based virtual screening.
    Molecular bioSystems, 2013, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Cerebral Hemorrhage; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Female; HeLa Cells; Heptanoic Acids; Humans; Lung Neoplasms; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Multiple Myeloma; Protein Kinase Inhibitors; Pyrroles; rho-Associated Kinases; Zebrafish

2013
Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis.
    Biomaterials, 2014, Volume: 35, Issue:26

    Topics: Animals; Atorvastatin; Breast; Breast Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Female; Heptanoic Acids; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Micelles; Oxidation-Reduction; Polyethylene Glycols; Pyrroles; Vitamin E

2014
Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor.
    Oncology reports, 2014, Volume: 32, Issue:4

    Topics: Atorvastatin; Benzophenones; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Transferases; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Androgen; RNA, Messenger; Transcriptional Activation; Triple Negative Breast Neoplasms

2014
Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration.
    Oncogene, 2015, Jun-11, Volume: 34, Issue:24

    Topics: Atorvastatin; Benzamides; Breast Neoplasms; Cell Movement; Cell Proliferation; Female; HEK293 Cells; Heptanoic Acids; Hippo Signaling Pathway; Humans; MCF-7 Cells; Prenylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Signal Transduction; Tumor Cells, Cultured

2015
Potentiated suppression of Dickkopf-1 in breast cancer by combined administration of the mevalonate pathway inhibitors zoledronic acid and statins.
    Breast cancer research and treatment, 2015, Volume: 154, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Diphosphonates; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Mevalonic Acid; Mice, Nude; Osteoblasts; Rosuvastatin Calcium; Simvastatin; Xenograft Model Antitumor Assays; Zoledronic Acid

2015
Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells.
    Cancer letters, 2016, May-28, Volume: 375, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; Biosynthetic Pathways; Breast Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Diphosphonates; Drug Synergism; Enzyme Activation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mevalonic Acid; rho GTP-Binding Proteins; Zoledronic Acid

2016
High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Apoptosis; Atorvastatin; Biosynthetic Pathways; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cholesterol; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MCF-7 Cells; Receptors, Estrogen; Survival Analysis

2016
Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin.
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 167

    Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Chromans; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hydroxymethylglutaryl CoA Reductases; MCF-7 Cells; Membrane Potential, Mitochondrial; Mevalonic Acid; Reactive Oxygen Species; Vitamin E

2017
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
    Cancer investigation, 2008, Volume: 26, Issue:7

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potential, Mitochondrial; Necrosis; Oxidative Stress; Pyrroles; Reactive Oxygen Species; Simvastatin

2008
Atorvastatin activates heme oxygenase-1 at the stress response elements.
    Journal of cellular and molecular medicine, 2012, Volume: 16, Issue:2

    Topics: Apoptosis; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Female; Heme Oxygenase-1; Heptanoic Acids; Humans; Male; Oxidative Stress; Polyisoprenyl Phosphates; Promoter Regions, Genetic; Prostatic Neoplasms; Pyrroles; Signal Transduction; Transcriptional Activation; Up-Regulation

2012
Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib.
    Journal of cellular physiology, 2011, Volume: 226, Issue:9

    Topics: Atorvastatin; Benzylamines; beta-Cyclodextrins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholesterol; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Gefitinib; Heptanoic Acids; Humans; Lovastatin; Membrane Microdomains; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Thiophenes

2011
Trastuzumab-related palmar plantar erythrodysaesthesia.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2012, Volume: 24, Issue:1

    Topics: Aged; Amlodipine; Antibodies, Monoclonal, Humanized; Anticholesteremic Agents; Antihypertensive Agents; Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Foot Dermatoses; Hand Dermatoses; Heptanoic Acids; Humans; Hypercholesterolemia; Hypertension; Pyrroles; Trastuzumab

2012
Inhibitory effect of statins on the proliferation of human breast cancer cells.
    International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:12

    Topics: Anticholesteremic Agents; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Antagonism; Estradiol; Estrogens; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Indoles; Neoplasms, Hormone-Dependent; Pyrroles

2004
Tamoxifen and hypertriglyceridemia.
    The Netherlands journal of medicine, 1999, Volume: 55, Issue:2

    Topics: Anticholesteremic Agents; Antineoplastic Agents, Hormonal; Atorvastatin; Breast Neoplasms; Clofibrate; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hyperlipoproteinemia Type II; Hypertriglyceridemia; Middle Aged; Pyrroles; Simvastatin; Tamoxifen; Treatment Outcome

1999
Statin induced myopathy does not show up in MIBI scintigraphy.
    Nuclear medicine communications, 2001, Volume: 22, Issue:5

    Topics: Adult; Anticholesteremic Agents; Atorvastatin; Breast Neoplasms; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Indoles; Lovastatin; Male; Middle Aged; Muscle, Skeletal; Muscular Diseases; Pain; Pravastatin; Pyridines; Pyrroles; Radionuclide Imaging; Radiopharmaceuticals; Simvastatin; Technetium Tc 99m Sestamibi

2001