Page last updated: 2024-08-24

atorvastatin and Brain Ischemia

atorvastatin has been researched along with Brain Ischemia in 69 studies

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (26.09)	29.6817
2010's	41 (59.42)	24.3611
2020's	10 (14.49)	2.80

Authors

Authors	Studies
Amarenco, P; Bath, PM; Chen, W; Gao, Y; Han, S; Jing, J; Johnston, SC; Li, H; Liu, L; Meng, X; Pan, Y; Wang, C; Wang, T; Wang, Y; Yang, Y; Zhao, X	1
Chen, H; Hu, Y; Qin, X; Wang, M; Wang, S; Wu, J; Wu, T; Wu, Y; Yang, R; Yu, H	1
Fujii, T; Ikari, Y; Murakami, T; Nakano, M; Nakazawa, G; Ohno, Y; Shinozaki, N; Yoshimachi, F	1
Arani, HZ; Jangholi, E; Karimi, A; Movassaghi, S; Parsa, Y; Sharifi, ZN; Yadollah-Damavandi, S	1
Chen, J; Chen, R; Huang, Y; Shang, W; Shi, G; Zhang, C; Zhang, L; Zhang, P; Zhang, X	1
Chen, Y; Fu, B; Li, P	1
Salayandia, VM; Thompson, JF; Torbey, M; Yang, LY; Yang, Y	1
Ghafouri-Fard, S; Ghiasian, M; Khazaei, M; Khosravi, M; Mazaheri, S; Mazdeh, M; Taheri, M	1
Choulerton, J; Guha, N; Squires, R	1
Choi, KC; Hong, DK; Kang, BS; Kho, AR; Park, KH; Park, WJ; Suh, SW	1
Faizi, M; Khodagholi, F; Naderi, N; Nasoohi, S; Nikseresht, S; Simani, L	1
Andrés Marín, N; Antigüedad-Muñoz, J; Arenaza Choperena, G; de la Riva, P; Fernández-Eulate, G; Martínez Zabaleta, M; Moreno Valladares, M; Muñoz Lopetegi, A	1
Cao, L; Chen, X; Ding, Y; Dong, Z; He, L; Li, Q; Peng, C; Ren, H; Shen, Y; Yi, X; Zhou, D	1
Dalugama, C; Gawarammana, IB	1
Chouksey, D; Dani, R; Dube, M; Dubey, A	1
Li, S; Li, SH; Li, YS; Liu, XJ; Shi, CH; Song, B; Xu, YM	1
Kang, X; Li, X; Lv, H; Wang, D; Zhang, G; Zhang, L; Zhang, Q	1
Chao, HC; Chiang, CS; Kuo, CH; Lee, TH; Tang, SC; Yang, SY	1
Aurigemma, C; D'Ambrosio, A; Di Sciascio, G; Giardina, A; Leporace, M; Macrì, M; Melfi, R; Patti, G; Ricottini, E; Sedati, P; Tomai, F	1
Delgado, G; Naves, M	1
Inaba, T; Kamiya, F; Katayama, Y; Katsura, K; Muraga, K; Nito, C; Saito, T; Ueda, M	1
Cardona-Gómez, GP; Garcia-Segura, LM; Gutierrez-Vargas, JA; Muñoz-Manco, JI	1
Deng, J; He, J; Hu, Z; Lei, Q; Liu, J; Lu, W; Song, T; Tao, X; Zhang, J; Zheng, L	1
Deng, JG; Liu, J; Song, T; Tao, X	1
Dong, X; Fang, X; Ji, X; Shen, J; Tao, D; Wang, Y	1
Guo, J; He, L; Li, J; Qin, F; Wu, B; Zhang, S; Zhou, D; Zhou, M	1
Angelopoulou, SM; Bouziana, SD; Giampatzis, V; Hatzitolios, AI; Konstantara, F; Kostaki, S; Papadopoulou, M; Savopoulos, C; Spanou, M; Tziomalos, K	1
Cheon, SY; Cho, KJ; Kim, GW	1
Chen, Y; Geng, J; Li, Y; Lin, Y; Mu, Z; Pan, Y; Shi, G; Song, Y; Sun, Y; Xu, Q; Yang, GY; Yu, L	1
Li, X; Pan, Y; Wang, X; Yang, J	1
Iijima, K; Imazeki, R; Kohara, S; Mizuma, A; Ohnuki, Y; Shimizu, M; Takizawa, S; Uesugi, T	1
Breker, DA; Gao, Z; Huang, Y; Li, Y; Mu, X; Zhang, J	1
Acha-Salazar, O; Larrosa-Campo, D; Novo-Robledo, F; Oterino, A; Palacio, E; Revilla, M; Viadero-Cervera, R	1
Arnao, V; Corpora, F; Della Corte, V; Di Bona, D; Di Raimondo, D; Iacopino, DG; Maida, C; Maugeri, R; Pecoraro, R; Pinto, A; Simonetta, I; Tuttolomondo, A	1
Ahmad, MA; Akhtar, M; Mujeeb, M; Najmi, AK	1
Bai, XD; Dila, NM; Hu, L; Li, YM; Liu, LY; Mao, JP; Yang, XY; Yue, YH; Zhang, HJ	1
Chen, G; Ge, X; Guo, L; Li, K; Luo, L; Shao, S; Xu, M; Zhang, F; Zhou, J; Zhu, Z	1
Császár, A	1
Amarenco, P; Callahan, A; Goldstein, LB; Hennerici, MG; Messig, M; Sillesen, H; Welch, KM; Zivin, J	1
Hanhart, J; Koskas, P; Le Mer, Y; Obadia, M; Paques, M; Sahel, JA	1
Amarenco, P; Benavente, O; Callahan, A; Gilbert, S; Goldstein, LB; Hennerici, MG; Rudolph, AE; Sillesen, H; Simunovic, L; Welch, KM; Zivin, JA	1
El-Remessy, AB; Elewa, HF; Ergul, A; Fagan, SC; Frye, RF; Johnson, MH; Kozak, A	1
Cui, L; Li, M; Liu, L; Wang, L; Yang, R; Zhang, X	1
Cui, L; Du, W; Li, M; Liu, L; Wang, L; Yang, R; Zhang, X	1
Athyros, VG; Karagiannis, A; Mikhailidis, DP; Tziomalos, K; Wierzbicki, AS	1
Boaz, M; Gilad, R; Lampl, Y; Lorberboym, M; Sadeh, M; Tikozky, A; Vysberg, I	1
Cardona-Gómez, GP; Céspedes-Rubio, A; Jurado, FW	1
Gaur, V; Kumar, A	1
Abe, A; Katayama, Y; Katsura, K; Nagayama, H; Nishiyama, Y; Otsuka, T; Ueda, M	1
Abe, K; Deguchi, K; Deguchi, S; Ikeda, Y; Kawai, H; Kurata, T; Matsuura, T; Ohta, Y; Omote, Y; Yamashita, T	1
Kasner, SE; Taylor, RA; Weigele, JB	1
Aout, M; Clarençon, F; Colonne, C; Fonfrede, M; Jean, B; Le Jean, L; Nouet, A; Puybasset, L; Sanchez-Peña, P; Vicaut, E	1
Beer, C; Blacker, D; Bynevelt, M; Hankey, GJ; Puddey, IB	1
Bhardwaj, A	1
Chen, ZC; Lou, M; Shi, ZH; Sun, JZ	1
Ding, X; Huang, S; Li, W; Lu, X; Sun, B; Wang, B; Zhang, Y	1
Böhm, M; Dirnagl, U; Endres, M; Gertz, K; Laufs, U; Lindauer, U; Nickenig, G	1
Amin-Hanjani, S; Asahi, M; Huang, PL; Huang, Z; Liao, JK; Lo, EH; Mori, T; Moskowitz, MA; Qiu, J; Sumii, T; Thomas, S; Yoshimura, S	1
Appel, K; Fiebich, BL; Hüll, M; Kauppinen, RA; Kettunen, M; Koistinaho, J; Yrjänheikki, J	1
Chopp, M; Kapke, A; Liu, XS; Lu, M; Morris, DC; Zhang, L; Zhang, ZG	1
Chopp, M; Ding, G; Ewing, JR; Jiang, Q; Li, L; Panda, S; Zhang, L; Zhang, ZG	1
Corado Ramírez, J; Eblen-Zajjurz, A; Oria de Suárez, C; Ponce Hernández, L; Suárez Rodríguez, S; Tovar Mendoza, R	1
Carod-Artal, FJ	1
Guyton, JR; Laskowitz, DT; Lynch, JR; Mace, B; Song, P; Wang, H; Warner, DS; Yang, HJ; Yates, RB	1
Kulbertus, H	1
Blanco, M; Castellanos, M; Castillo, J; Dávalos, A; García-Gil, M; Leira, R; Lizasoain, I; Moro, MA; Nombela, F; Rodriguez-Yáñez, M; Serena, J; Vivancos, J	1
Bassi, A; Caltagirone, C; Colivicchi, F; Santini, M	1
Böhm, M; Dirnagl, U; Endres, M; Gertz, K; Huang, P; Laufs, U; Nickenig, G	1
Basson, CT; Delanty, N; Vaughan, CJ	1

Reviews

4 review(s) available for atorvastatin and Brain Ischemia

Article	Year
[Important aim of statin therapy: ischemic cardiovascular event (stroke)]. Ideggyogyaszati szemle, 2008, Jul-30, Volume: 61, Issue:7-8 Topics: Acute Disease; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Meta-Analysis as Topic; Myocardial Ischemia; Pyrroles; Recurrence; Stroke	2008
Aggressive statin treatment, very low serum cholesterol levels and haemorrhagic stroke: is there an association? Current opinion in cardiology, 2010, Volume: 25, Issue:4 Topics: Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Coronary Artery Disease; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Intracranial Hemorrhages; Primary Prevention; Pyrroles; Risk Factors; Secondary Prevention; Stroke	2010
Current management of symptomatic intracranial stenosis. Current atherosclerosis reports, 2011, Volume: 13, Issue:4 Topics: Angioplasty; Anticoagulants; Atorvastatin; Brain; Brain Ischemia; Cilostazol; Constriction, Pathologic; Endovascular Procedures; Fibrinolytic Agents; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Arteriosclerosis; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Stents; Stroke; Tetrazoles	2011
Statin therapy and stroke prevention. Current opinion in cardiology, 2001, Volume: 16, Issue:4 Topics: Anti-Inflammatory Agents; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Encephalitis; Endothelium, Vascular; Fibrinolytic Agents; Heptanoic Acids; Humans; Lovastatin; Nitric Oxide Synthase; Pyrroles; Stroke	2001

Trials

8 trial(s) available for atorvastatin and Brain Ischemia

Article	Year
Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclero Stroke and vascular neurology, 2023, Volume: 8, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Atorvastatin; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Ischemic Stroke; Middle Aged; Platelet Aggregation Inhibitors; Stroke	2023
The effect of atorvastatin on the common carotid artery intima-media thickness in patients with ischemic stroke. Acta clinica Croatica, 2020, Volume: 59, Issue:2 Topics: Atorvastatin; Brain Ischemia; Carotid Arteries; Carotid Artery, Common; Carotid Intima-Media Thickness; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Stroke; Prospective Studies; Risk Factors; Stroke	2020
Strategies of clopidogrel load and atorvastatin reload to prevent ischemic cerebral events in patients undergoing protected carotid stenting. Results of the randomized ARMYDA-9 CAROTID (Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Journal of the American College of Cardiology, 2013, Apr-02, Volume: 61, Issue:13 Topics: Aged; Angioplasty, Balloon; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Diffusion Magnetic Resonance Imaging; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Male; Platelet Aggregation Inhibitors; Pyrroles; Research Design; Stents; Ticlopidine; Treatment Outcome	2013
Early High-dosage Atorvastatin Treatment Improved Serum Immune-inflammatory Markers and Functional Outcome in Acute Ischemic Strokes Classified as Large Artery Atherosclerotic Stroke: A Randomized Trial. Medicine, 2016, Volume: 95, Issue:13 Topics: Acute Disease; Aged; Atorvastatin; Biomarkers; Brain Ischemia; E-Selectin; Female; Humans; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1beta; Interleukin-6; Intracranial Arteriosclerosis; Male; Middle Aged; P-Selectin; Stroke; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	2016
Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial by stroke subtypes. Stroke, 2009, Volume: 40, Issue:4 Topics: Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Placebos; Proportional Hazards Models; Pyrroles; Risk Factors; Stroke; Treatment Outcome	2009
Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients. Journal of atherosclerosis and thrombosis, 2011, Volume: 18, Issue:2 Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Linear Models; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Quinolines; Stroke	2011
A randomized placebo controlled trial of early treatment of acute ischemic stroke with atorvastatin and irbesartan. International journal of stroke : official journal of the International Stroke Society, 2012, Volume: 7, Issue:2 Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Atorvastatin; Biphenyl Compounds; Brain Ischemia; Cerebral Infarction; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Irbesartan; Male; Middle Aged; Monitoring, Physiologic; Pyrroles; Sample Size; Stroke; Tetrazoles; Tomography, X-Ray Computed; Treatment Outcome	2012
Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology, 2007, Aug-28, Volume: 69, Issue:9 Topics: Acute Disease; Aged; Atorvastatin; Brain Ischemia; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Neuroprotective Agents; Odds Ratio; Pyrroles; Risk Factors; Stroke; Survival Analysis; Time Factors; Treatment Outcome; Withholding Treatment	2007

Other Studies

57 other study(ies) available for atorvastatin and Brain Ischemia

Article	Year
Is statin therapy after ischaemic stroke associated with increased intracerebral hemorrhage? The association may be dependent on intensity of statin therapy. International journal of stroke : official journal of the International Stroke Society, 2023, Volume: 18, Issue:8 Topics: Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Stroke; Rosuvastatin Calcium; Simvastatin; Stroke	2023
Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting. Heart and vessels, 2020, Volume: 35, Issue:6 Topics: Aged; Atorvastatin; Brain Ischemia; Carotid Artery Diseases; Diffusion Magnetic Resonance Imaging; Drug Administration Schedule; Endovascular Procedures; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Retrospective Studies; Risk Factors; Rosuvastatin Calcium; Stents; Stroke; Time Factors; Treatment Outcome	2020
Atorvastatin Prevents the Neuron Loss in the Hippocampal Dentate Gyrus Region through its Anti-Oxidant and Anti-Apoptotic Activities. CNS & neurological disorders drug targets, 2021, Volume: 20, Issue:1 Topics: Animals; Antioxidants; Apoptosis; Atorvastatin; Brain Ischemia; Cell Death; Dentate Gyrus; Hippocampus; In Situ Nick-End Labeling; Male; Mitochondria; Nerve Degeneration; Neurons; Oxidative Stress; Rats; Reperfusion Injury	2021
Atorvastatin alleviates microglia-mediated neuroinflammation via modulating the microbial composition and the intestinal barrier function in ischemic stroke mice. Free radical biology & medicine, 2021, Volume: 162 Topics: Animals; Atorvastatin; Brain Ischemia; Ischemic Stroke; Mice; Mice, Inbred C57BL; Microglia; Stroke	2021
2019 novel coronavirus disease with secondary ischemic stroke: two case reports. BMC neurology, 2021, Jan-05, Volume: 21, Issue:1 Topics: Aspirin; Atorvastatin; Brain Ischemia; COVID-19; Fibrinolytic Agents; Humans; Ischemic Stroke; Male; Middle Aged; Pandemics; SARS-CoV-2; Tirofiban	2021
Treatment with Atorvastatin During Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke. Translational stroke research, 2021, Volume: 12, Issue:5 Topics: Animals; Atorvastatin; Blood-Brain Barrier; Brain Ischemia; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Pericytes; Rats; Stroke; Vascular Remodeling	2021
Anabolic steroid use and ischaemic stroke in a young fitness enthusiast. BMJ case reports, 2021, Feb-04, Volume: 14, Issue:2 Topics: Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Atorvastatin; Brain Ischemia; Clomiphene; Doping in Sports; Echocardiography; Estrogen Antagonists; Exercise; Heart Septal Defects, Atrial; Humans; Ischemic Stroke; Male; Tamoxifen; Testosterone Congeners	2021
The Effects of Atorvastatin on Global Cerebral Ischemia-Induced Neuronal Death. International journal of molecular sciences, 2021, Apr-22, Volume: 22, Issue:9 Topics: Animals; Atorvastatin; Behavior, Animal; Brain Ischemia; Cognition Disorders; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley	2021
Coenzyme Q10 supplementation improves acute outcomes of stroke in rats pretreated with atorvastatin. Nutritional neuroscience, 2019, Volume: 22, Issue:4 Topics: Animals; Apoptosis; Atorvastatin; Brain Ischemia; Encephalitis; Male; Neuroprotective Agents; Oxidative Stress; Rats, Wistar; Stroke; Treatment Outcome; Ubiquinone	2019
Internal Carotid Artery Web as the Cause of Recurrent Cryptogenic Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:5 Topics: Adult; Aspirin; Atorvastatin; Biopsy; Brain Ischemia; Cardiovascular Agents; Carotid Artery Diseases; Carotid Artery, Internal; Computed Tomography Angiography; Female; Fibromuscular Dysplasia; Humans; Hyperplasia; Neointima; Recurrence; Risk Factors; Stroke	2018
Polymorphisms in CYP450 Genes and the Therapeutic Effect of Atorvastatin on Ischemic Stroke: A Retrospective Cohort Study in Chinese Population. Clinical therapeutics, 2018, Volume: 40, Issue:3 Topics: Aged; Alleles; Asian People; Atorvastatin; Brain Ischemia; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Retrospective Studies; Stroke	2018
Ischemic stroke following a wasp sting - a rare complication: a case report. Journal of medical case reports, 2018, Oct-14, Volume: 12, Issue:1 Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Atorvastatin; Brain; Brain Ischemia; Humans; Insect Bites and Stings; Magnetic Resonance Imaging; Male; Stroke; Wasps	2018
Twenty-and-a-half syndrome: a case report. Journal of medical case reports, 2019, Feb-15, Volume: 13, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atorvastatin; Brain; Brain Ischemia; Cranial Nerve Diseases; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnetic Resonance Imaging; Middle Aged; Paresis; Physical Therapy Modalities; Platelet Aggregation Inhibitors; Ramipril; Stroke; Syndrome	2019
Association of CYP3A41G and CYP3A53 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019, Volume: 28, Issue:7 Topics: Aged; Asian People; Atorvastatin; Brain Ischemia; China; Cytochrome P-450 CYP3A; Disability Evaluation; Female; Gene Frequency; Homozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Recovery of Function; Secondary Prevention; Stroke; Time Factors; Treatment Outcome	2019
Association of SLCO1B1 and ABCB1 Genetic Variants with Atorvastatin-induced Myopathy in Patients with Acute Ischemic Stroke. Current pharmaceutical design, 2019, Volume: 25, Issue:14 Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Brain Ischemia; Case-Control Studies; Genotype; Humans; Liver-Specific Organic Anion Transporter 1; Muscular Diseases; Polymorphism, Single Nucleotide; Stroke	2019
Sphingolipidomics Investigation of the Temporal Dynamics after Ischemic Brain Injury. Journal of proteome research, 2019, 09-06, Volume: 18, Issue:9 Topics: Animals; Atorvastatin; Brain; Brain Injuries; Brain Ischemia; Ceramides; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Lipidomics; Lysophospholipids; Mice; Sphingolipids; Sphingosine; Stroke; Tandem Mass Spectrometry	2019
Compliance and echographic carotid plaque evolution in patients with acute ischemic stroke treated with atorvastatin according to usual care. Vascular, 2014, Volume: 22, Issue:3 Topics: Aged; Atorvastatin; Brain Ischemia; Carotid Arteries; Carotid Artery Diseases; Cholesterol, HDL; Cholesterol, LDL; Drug Monitoring; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hypolipidemic Agents; Lipid Metabolism; Male; Medication Adherence; Plaque, Atherosclerotic; Prospective Studies; Pyrroles; Spain; Stroke; Triglycerides; Ultrasonography	2014
Continuous oral administration of atorvastatin ameliorates brain damage after transient focal ischemia in rats. Life sciences, 2014, Jan-17, Volume: 94, Issue:2 Topics: Administration, Oral; Animals; Atorvastatin; Brain; Brain Edema; Brain Ischemia; DNA Damage; Heptanoic Acids; Lipid Peroxidation; Magnetic Resonance Imaging; Male; Microglia; Neuroimaging; Neuroprotective Agents; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha	2014
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia. Journal of neuroscience research, 2014, Volume: 92, Issue:11 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Heptanoic Acids; Male; Maze Learning; Nerve Tissue Proteins; Nervous System Diseases; Piperidines; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Somatosensory Cortex; Time Factors	2014
HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats. Neurological research, 2015, Volume: 37, Issue:3 Topics: Animals; Apoptosis; Atorvastatin; Blotting, Western; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Heat-Shock Proteins; Heptanoic Acids; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Tetrazolium Salts	2015
Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore. Genetics and molecular research : GMR, 2014, Dec-18, Volume: 13, Issue:4 Topics: Animals; Anticholesteremic Agents; Apoptosis; Atorvastatin; Brain Ischemia; Cytochromes c; Disease Models, Animal; Heptanoic Acids; Infarction, Middle Cerebral Artery; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Pyrroles; Rats, Sprague-Dawley; Reperfusion Injury	2014
Neuroprotective effects and dynamic expressions of MMP9 and TIMP1 associated with atorvastatin pretreatment in ischemia-reperfusion rats. Neuroscience letters, 2015, Aug-31, Volume: 603 Topics: Animals; Atorvastatin; Brain; Brain Infarction; Brain Ischemia; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Tissue Inhibitor of Metalloproteinase-1	2015
Statin treatment reduces the risk of poststroke seizures. Neurology, 2015, Aug-25, Volume: 85, Issue:8 Topics: Aged; Aged, 80 and over; Atorvastatin; Brain Ischemia; Cohort Studies; Epilepsy; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Rosuvastatin Calcium; Seizures; Simvastatin; Stroke; Time Factors; Treatment Outcome	2015
Comparative effects of more versus less aggressive treatment with statins on the long-term outcome of patients with acute ischemic stroke. Atherosclerosis, 2015, Volume: 243, Issue:1 Topics: Aged; Atorvastatin; Brain Ischemia; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Rosuvastatin Calcium; Stroke; Treatment Outcome	2015
Statins Promote Long-Term Recovery after Ischemic Stroke by Reconnecting Noradrenergic Neuronal Circuitry. Neural plasticity, 2015, Volume: 2015 Topics: Animals; Atorvastatin; Behavior, Animal; Brain Ischemia; Cell Proliferation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Locus Coeruleus; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neurogenesis; Recovery of Function; Stroke; Sympathetic Nervous System	2015
Early Use of Statin in Patients Treated with Alteplase for Acute Ischemic Stroke. Acta neurochirurgica. Supplement, 2016, Volume: 121 Topics: Aged; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Early Medical Intervention; Female; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Risk Factors; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Treatment Outcome	2016
Atorvastatin attenuates cognitive deficits through Akt1/caspase-3 signaling pathway in ischemic stroke. Brain research, 2015, Dec-10, Volume: 1629 Topics: Animals; Atorvastatin; Brain Ischemia; Caspase 3; Cognition Disorders; Male; Maze Learning; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Stroke	2015
Effect of atorvastatin co-treatment on inhibition of platelet activation by clopidogrel in patients with ischemic stroke. International journal of stroke : official journal of the International Stroke Society, 2015, Volume: 10, Issue:8 Topics: Aged; Atorvastatin; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Activation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine	2015
Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke. The International journal of neuroscience, 2017, Volume: 127, Issue:1 Topics: Aged; Atorvastatin; Brain Ischemia; Brain-Derived Neurotrophic Factor; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Outcome Assessment, Health Care; Recovery of Function; Stroke	2017
[Utility of treatment with atorvastatin 40 mg plus ezetimibe 10 mg versus atorvastatin 80 mg in reducing the levels of LDL cholesterol in patients with ischaemic stroke or transient ischaemic attack]. Revista de neurologia, 2016, Mar-01, Volume: 62, Issue:5 Topics: Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Male; Middle Aged; Retrospective Studies; Stroke	2016
Protective Effect of Guggulipid in High Fat Diet and Middle Cerebral Artery Occlusion (MCAO) Induced Ischemic Cerebral Injury in Rats. Drug research, 2016, Volume: 66, Issue:8 Topics: Animals; Aspirin; Atorvastatin; Brain; Brain Ischemia; Catalase; Commiphora; Diet, High-Fat; Drug Therapy, Combination; Female; Glutathione; Hand Strength; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Locomotion; Male; Neuroprotective Agents; Phytotherapy; Plant Extracts; Plant Gums; Rats; Superoxide Dismutase	2016
Gene Polymorphisms Affect the Effectiveness of Atorvastatin in Treating Ischemic Stroke Patients. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 39, Issue:2 Topics: Aged; Anticholesteremic Agents; Apolipoprotein A-V; Atorvastatin; Brain Ischemia; Cholesterol Ester Transfer Proteins; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hydroxymethylglutaryl CoA Reductases; Lipoprotein Lipase; Lipoproteins, HDL; Lipoproteins, LDL; Middle Aged; Polymorphism, Single Nucleotide; Proprotein Convertase 9; Stroke	2016
Atorvastatin Attenuates Ischemia/Reperfusion-Induced Hippocampal Neurons Injury Via Akt-nNOS-JNK Signaling Pathway. Cellular and molecular neurobiology, 2017, Volume: 37, Issue:4 Topics: Animals; Apoptosis; Atorvastatin; Brain Ischemia; Hippocampus; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reperfusion Injury	2017
Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke, 2008, Volume: 39, Issue:12 Topics: Aged; Atorvastatin; Brain Ischemia; Carotid Stenosis; Cerebral Hemorrhage; Cholesterol, LDL; Coronary Disease; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ischemic Attack, Transient; Male; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic; Recurrence; Risk; Treatment Outcome	2008
[Brain hypoperfusion revealed by an ocular ischemic syndrome]. Journal francais d'ophtalmologie, 2008, Volume: 31, Issue:8 Topics: Antihypertensive Agents; Aspirin; Atorvastatin; Brain Ischemia; Carotid Artery Thrombosis; Ciliary Body; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Ischemia; Light Coagulation; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Middle Aged; Ophthalmic Artery; Platelet Aggregation Inhibitors; Pyrroles; Recurrence; Stroke; Ultrasonography	2008
Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:2 Topics: Acute Disease; Animals; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Diabetes Mellitus, Type 2; Drug Administration Schedule; Heptanoic Acids; Male; Pyrroles; Rats; Rats, Wistar; Time Factors	2009
Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kappaB expression. Neuroscience letters, 2010, Mar-08, Volume: 471, Issue:3 Topics: Animals; Atorvastatin; Behavior, Animal; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Down-Regulation; Heptanoic Acids; HMGB1 Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; NF-kappa B; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Toll-Like Receptor 4	2010
Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability. Brain research, 2010, Apr-14, Volume: 1325 Topics: Acute Disease; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Atorvastatin; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Down-Regulation; Heptanoic Acids; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Cytosolic; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Stroke; Time Factors	2010
Early outcome of acute ischemic stroke in hyperlipidemic patients under atorvastatin versus simvastatin. Clinical neuropharmacology, 2010, Volume: 33, Issue:3 Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hyperlipidemias; Lipids; Male; Medical Records; Middle Aged; Neuroprotective Agents; Pyrroles; Retrospective Studies; Severity of Illness Index; Simvastatin; Statistics as Topic; Stroke; Stroke Rehabilitation; Treatment Outcome	2010
p120 catenin/αN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia. Journal of neuroscience research, 2010, Volume: 88, Issue:16 Topics: alpha Catenin; Analysis of Variance; Animals; Atorvastatin; Brain Ischemia; Catenins; Cell Adhesion Molecules; Cell Death; Cerebral Cortex; Delta Catenin; Gene Expression Regulation; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Longitudinal Studies; Male; Nerve Tissue Proteins; Neuronal Plasticity; Neuroprotective Agents; Protein Isoforms; Pyrroles; Rats; Rats, Wistar; Statistics, Nonparametric; Synapses	2010
Neuroprotective potentials of candesartan, atorvastatin and their combination against stroke induced motor dysfunction. Inflammopharmacology, 2011, Volume: 19, Issue:4 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atorvastatin; Behavior, Animal; Benzimidazoles; Biphenyl Compounds; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mitochondria; Motor Activity; Movement Disorders; Neurons; Organ Specificity; Oxidative Stress; Pyrroles; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Stroke; Tetrazoles	2011
Protection against ischemic stroke damage by synergistic treatment with amlodipine plus atorvastatin in Zucker metabolic rat. Brain research, 2011, Mar-25, Volume: 1382 Topics: Amlodipine; Animals; Atorvastatin; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nerve Degeneration; Neuroprotective Agents; Pyrroles; Rats; Rats, Zucker; Stroke	2011
Atorvastatin decreases computed tomography and S100-assessed brain ischemia after subarachnoid aneurysmal hemorrhage: a comparative study. Critical care medicine, 2012, Volume: 40, Issue:2 Topics: Adult; Aged; Atorvastatin; Biomarkers; Brain Ischemia; Case-Control Studies; Confidence Intervals; Critical Care; Critical Illness; Female; Follow-Up Studies; Glasgow Coma Scale; Heptanoic Acids; Hospitals, University; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Male; Middle Aged; Nerve Growth Factors; Predictive Value of Tests; Pyrroles; Retrospective Studies; Risk Assessment; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Severity of Illness Index; Statistics, Nonparametric; Subarachnoid Hemorrhage; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome; Vasospasm, Intracranial	2012
Statins as neuroprotectants after subarachnoid hemorrhage. Critical care medicine, 2012, Volume: 40, Issue:2 Topics: Atorvastatin; Brain Ischemia; Female; Heptanoic Acids; Humans; Male; Nerve Growth Factors; Pyrroles; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Subarachnoid Hemorrhage	2012
Capsular warning syndrome caused by spontaneous middle cerebral artery dissection. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:8 Topics: Angiography, Digital Subtraction; Aspirin; Atorvastatin; Brain Ischemia; Cerebral Angiography; Diffusion Magnetic Resonance Imaging; Echocardiography; Electrocardiography; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Middle Cerebral Artery; Platelet Aggregation Inhibitors; Pyrroles; Smoking	2012
Atorvastatin and whisker stimulation synergistically enhance angiogenesis in the barrel cortex of rats following focal ischemia. Neuroscience letters, 2012, Sep-13, Volume: 525, Issue:2 Topics: Animals; Atorvastatin; Brain Ischemia; Brain-Derived Neurotrophic Factor; Fluorescent Antibody Technique; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Microvessels; Neovascularization, Physiologic; Pyrroles; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Vascular Endothelial Growth Factor A; Vibrissae	2012
Withdrawal of statin treatment abrogates stroke protection in mice. Stroke, 2003, Volume: 34, Issue:2 Topics: Animals; Aorta; Atorvastatin; Bleeding Time; Blood Coagulation; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligation; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Activation; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Stroke; Substance Withdrawal Syndrome; Vena Cava, Inferior; Venous Thrombosis	2003
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6 Topics: Animals; Atorvastatin; Brain Ischemia; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Embolism; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Simvastatin; Stroke; Tissue Plasminogen Activator	2005
Long-term protective effect of atorvastatin in permanent focal cerebral ischemia. Brain research, 2005, Aug-09, Volume: 1052, Issue:2 Topics: Animals; Atorvastatin; Behavior, Animal; Blood Circulation; Brain Infarction; Brain Ischemia; Dizocilpine Maleate; Heptanoic Acids; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Motor Activity; Neuroprotective Agents; Psychomotor Performance; Pyrroles; Rats; Rats, Long-Evans; Recovery of Function; Staining and Labeling; Time; Time Factors	2005
Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2006, Volume: 26, Issue:6 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blood Coagulation; Brain; Brain Ischemia; Capillary Permeability; Down-Regulation; Endothelial Cells; Gene Expression; Heptanoic Acids; Humans; Lasers; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microdissection; Pyrroles; Rats; Rats, Wistar; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Tissue Plasminogen Activator	2006
MRI of combination treatment of embolic stroke in rat with rtPA and atorvastatin. Journal of the neurological sciences, 2006, Jul-15, Volume: 246, Issue:1-2 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Data Interpretation, Statistical; Heptanoic Acids; Intracranial Embolism; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Microcirculation; Microscopy, Fluorescence; Plasminogen Activators; Pyrroles; Rats; Rats, Wistar; Recombinant Proteins; Stroke	2006
[Effect of atorvastatin on Fas (CD95/Apo-1) expression in normal or ischemic brain]. Anales de medicina interna (Madrid, Spain : 1984), 2006, Volume: 23, Issue:4 Topics: Animals; Apoptosis; Atorvastatin; Brain Ischemia; fas Receptor; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Pyrroles; Rats; Rats, Sprague-Dawley	2006
Statins and cerebral vasomotor reactivity: implications for a new therapy? Stroke, 2006, Volume: 37, Issue:10 Topics: Adult; Animals; Arginine; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Clinical Trials, Phase II as Topic; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Intracranial Aneurysm; Mice; Middle Cerebral Artery; Nitric Oxide; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Simvastatin; Stroke; Subarachnoid Hemorrhage; Ultrasonography, Doppler, Transcranial; Vasodilation; Vasomotor System; Vasospasm, Intracranial	2006
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Experimental neurology, 2007, Volume: 206, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Brain Edema; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Cognition Disorders; Cytokines; Disease Models, Animal; Encephalitis; Endothelial Cells; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Pyrroles; Recovery of Function; RNA, Messenger; Simvastatin; Treatment Outcome	2007
[The 2006 American Heart Association selection of the "top ten advances in heart disease and stroke research"]. Revue medicale de Liege, 2007, Volume: 62, Issue:4 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; American Heart Association; Anti-Inflammatory Agents; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Brain Ischemia; Child; Coronary Disease; Heart Diseases; Heart Valve Prosthesis; Heart-Assist Devices; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Obesity; Peptidyl-Dipeptidase A; Process Assessment, Health Care; Pyrroles; Stroke; Tissue Engineering; United States	2007
Discontinuation of statin therapy and clinical outcome after ischemic stroke. Stroke, 2007, Volume: 38, Issue:10 Topics: Aged; Atorvastatin; Brain Ischemia; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Pyrroles; Simvastatin; Stroke; Substance Withdrawal Syndrome	2007
Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke, 2000, Volume: 31, Issue:10 Topics: Animals; Aorta; Atorvastatin; beta-Thromboglobulin; Blood Coagulation; Blood Platelets; Brain Ischemia; Cholesterol; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Mice; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Activation; Platelet Factor 4; Pyrroles; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA, Messenger; Up-Regulation	2000