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atenolol and Ventricular Fibrillation

atenolol has been researched along with Ventricular Fibrillation in 33 studies

Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
atenolol : An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.

Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.

Research Excerpts

ExcerptRelevanceReference
"0 h after the onset of suspected acute myocardial infarction were randomised either to a control group or to a group receiving atenolol (5-10 mg iv immediately, followed by 100 mg/day orally for 7 days)."9.06Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group. ( , 1986)
"Metoprolol and other beta-adrenergic blocking drugs are known to exert cardioprotective effects that include significant reduction in occurrence of ventricular fibrillation (VF) following myocardial ischemia and infarction."7.67Effects of metoprolol, alone and in combination with lidocaine, on ventricular fibrillation threshold: comparison with atenolol, propranolol, and pindolol. ( Beil, ME; Cabot, CF; Coram, WM; Olson, RW; Weiss, GB, 1987)
"Ventricular fibrillation was induced in 20 Landrace/Large White piglets, which were left untreated for 8 minutes before attempted resuscitation with precordial compression, mechanical ventilation, and electrical defibrillation."5.35Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation. ( Bassiakou, E; Goulas, S; Koudouna, E; Papadimitriou, D; Papadimitriou, L; Prapa, V; Rokas, G; Xanthos, T, 2008)
"Ischemia-induced arrhythmias were studied during a 30 min period of occlusion of the left anterior descending (LAD) coronary artery, and 100% of control animals (n = 24) exhibited ventricular tachycardia and 63% ventricular fibrillation."5.27Ischemia- and reperfusion-induced arrhythmias in conscious rats--studies with prazosin and atenolol. ( Braimbridge, MV; Hearse, DJ; Kinoshita, K; Manning, AS, 1988)
"The greater sensitivity of phase 1a arrhythmias to beta-blockade and the lack of a decrease in ventricular fibrillation threshold during phase 1b might indicate differences in the genesis of arrhythmias and fibrillation in phases 1a and 1b."5.26Prophylaxis of ventricular fibrillation after acute experimental coronary occlusion by chronic beta-adrenoceptor blockade with atenolol. ( Bucher, P; Meesmann, W; Menken, U; Wiegand, V, 1979)
"0 h after the onset of suspected acute myocardial infarction were randomised either to a control group or to a group receiving atenolol (5-10 mg iv immediately, followed by 100 mg/day orally for 7 days)."5.06Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group. ( , 1986)
"In a large randomised trial of early beta-blockade in acute myocardial infarction (ISIS-1), almost all the reduction in mortality associated with the use of atenolol occurred on the day of admission or on the subsequent day."5.06Mechanisms for the early mortality reduction produced by beta-blockade started early in acute myocardial infarction: ISIS-1. ISIS-1 (First International Study of Infarct Survival) Collaborative Group. ( , 1988)
" During ischemia alone, the incidence of ventricular fibrillation in animals who underwent all phases of the study was 6 of 9; with atenolol (0."3.69Anti-arrhythmic efficacy of beta-adrenergic blockade during acute ischemia in myocardium with scar. ( Fusilli, L; Lee, W; Patel, J; Regan, TJ, 1994)
"Metoprolol and other beta-adrenergic blocking drugs are known to exert cardioprotective effects that include significant reduction in occurrence of ventricular fibrillation (VF) following myocardial ischemia and infarction."3.67Effects of metoprolol, alone and in combination with lidocaine, on ventricular fibrillation threshold: comparison with atenolol, propranolol, and pindolol. ( Beil, ME; Cabot, CF; Coram, WM; Olson, RW; Weiss, GB, 1987)
"We analyzed the incidence and recurrence rate of early and late primary VF in 9,720 patients with a first acute MI, treated with thrombolytics, enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-2 trial."2.69Incidence and prognosis of early primary ventricular fibrillation in acute myocardial infarction--results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2) database. ( Cavalli, A; Negri, E; Santoro, L; Volpi, A, 1998)
"Diazepam treatment significantly reduced cumulative seizure behaviors by 79% compared to saline-treated animals but offered no cardiac protection."1.48Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure. ( Harrison, JC; Kerr, DS; McCann, DM; Millen, RN; Read, MI; Sammut, IA, 2018)
"In 5 of 6 SHAM-treated animals, ventricular fibrillation (VF) occurred during LAD occlusion."1.39Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs. ( Böhm, M; Linz, B; Linz, D; Mahfoud, F; Neuberger, HR; Pöss, J; Ukena, C; Wirth, K, 2013)
"Two patients with hypertrophic cardiomyopathy are reported from the recent experience of the Hypertrophic Cardiomyopathy Center of the Minneapolis Heart Institute Foundation, demonstrating limitations in the risk stratification algorithm currently used for this disease."1.35Sudden cardiac arrest in hypertrophic cardiomyopathy in the absence of conventional criteria for high risk status. ( Appelbaum, E; Haas, TS; Harrigan, CJ; Hauser, RG; Lesser, JR; Main, ML; Maron, BJ; Maron, MS; Roberts, WC, 2008)
" The doses for each drug were selected based on the results of dose-response curves."1.27Adrenergic effects on internal cardiac defibrillation threshold. ( Jones, DL; Klein, GJ; Rattes, MF; Sharma, AD; Szabo, T, 1987)
"Ischemia-induced arrhythmias were studied during a 30 min period of occlusion of the left anterior descending (LAD) coronary artery, and 100% of control animals (n = 24) exhibited ventricular tachycardia and 63% ventricular fibrillation."1.27Ischemia- and reperfusion-induced arrhythmias in conscious rats--studies with prazosin and atenolol. ( Braimbridge, MV; Hearse, DJ; Kinoshita, K; Manning, AS, 1988)
"The greater sensitivity of phase 1a arrhythmias to beta-blockade and the lack of a decrease in ventricular fibrillation threshold during phase 1b might indicate differences in the genesis of arrhythmias and fibrillation in phases 1a and 1b."1.26Prophylaxis of ventricular fibrillation after acute experimental coronary occlusion by chronic beta-adrenoceptor blockade with atenolol. ( Bucher, P; Meesmann, W; Menken, U; Wiegand, V, 1979)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199018 (54.55)18.7374
1990's5 (15.15)18.2507
2000's7 (21.21)29.6817
2010's3 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Read, MI1
Millen, RN1
McCann, DM1
Harrison, JC1
Kerr, DS1
Sammut, IA1
Linz, D1
Wirth, K1
Ukena, C1
Mahfoud, F1
Pöss, J1
Linz, B1
Böhm, M1
Neuberger, HR1
Bassiakou, E1
Xanthos, T1
Koudouna, E1
Goulas, S1
Prapa, V1
Papadimitriou, D1
Rokas, G1
Papadimitriou, L1
He, G1
Hu, J1
Li, T1
Ma, X1
Meng, J1
Jia, M1
Lu, J1
Ohtsu, H1
Chen, Z1
Luo, X1
Imajo, N1
Matsui, S1
Yasui, Y1
Matsui, N1
Fukuishi, N1
Akagi, M1
Blagova, OV1
Nedostup, AV1
Ablad, B1
Bjurö, T1
Björkman, JA1
Edström, T1
Murphy, I1
Moneley, D1
Kelly, D1
Foley, B1
Sheehan, S1
Maron, BJ1
Maron, MS1
Lesser, JR1
Hauser, RG1
Haas, TS1
Harrigan, CJ1
Appelbaum, E1
Main, ML1
Roberts, WC1
Laakso, M1
Pentikäinen, PJ1
Pyörälä, K1
Neuvonen, PJ1
Thandroyen, FT1
Worthington, MG1
Higginson, LM1
Opie, LH3
Patterson, E1
Lucchesi, BR1
Lubbe, WF2
Muller, CA1
Worthington, M1
McFadyen, EL1
Djonlagić, H1
Bos, I1
Diederich, KW1
Lu, HR1
Remeysen, P1
De Clerck, F1
Patel, J1
Lee, W1
Fusilli, L1
Regan, TJ1
Adamson, PB1
Huang, MH1
Vanoli, E1
Foreman, RD1
Schwartz, PJ1
Hull, SS1
Raza, A1
Volpi, A1
Cavalli, A1
Santoro, L1
Negri, E1
Clements-Jewery, H1
Curtis, MJ1
Podzuweit, T1
Daries, PS1
Wiegand, V2
Güggi, M1
Meesmann, W3
Kessler, M1
Greitschus, F1
Menken, U1
Bucher, P1
Abendroth, RR1
Stephan, K1
Schley, G1
Hübner, H1
Coram, WM1
Olson, RW1
Beil, ME1
Cabot, CF1
Weiss, GB1
Ren, XL1
Lin, CX1
Rattes, MF1
Sharma, AD1
Klein, GJ1
Szabo, T1
Jones, DL1
Odugbesan, O1
Chesner, IM1
Bailey, G1
Barnett, AH1
Kinoshita, K1
Hearse, DJ1
Braimbridge, MV1
Manning, AS1

Trials

6 trials available for atenolol and Ventricular Fibrillation

ArticleYear
Prevention of ventricular fibrillation requires central beta-adrenoceptor blockade in rabbits.
    Scandinavian cardiovascular journal : SCJ, 2007, Volume: 41, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Baroreflex; Blood Pressure; Central Nervous System;

2007
Incidence and prognosis of early primary ventricular fibrillation in acute myocardial infarction--results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2) database.
    The American journal of cardiology, 1998, Aug-01, Volume: 82, Issue:3

    Topics: Anti-Arrhythmia Agents; Anticoagulants; Aspirin; Atenolol; Drug Administration Routes; Electrocardio

1998
Anti-dysrhythmic treatment in acute myocardial infarction.
    Lancet (London, England), 1979, Jan-27, Volume: 1, Issue:8109

    Topics: Acute Disease; Administration, Oral; Atenolol; Clinical Trials as Topic; Disopyramide; Double-Blind

1979
Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group.
    Lancet (London, England), 1986, Jul-12, Volume: 2, Issue:8498

    Topics: Administration, Oral; Age Factors; Aged; Atenolol; Cardiotonic Agents; Clinical Trials as Topic; Dru

1986
Intravenous beta-blockade during acute myocardial infarction.
    Lancet (London, England), 1986, Jul-12, Volume: 2, Issue:8498

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Humans; Injec

1986
Mechanisms for the early mortality reduction produced by beta-blockade started early in acute myocardial infarction: ISIS-1. ISIS-1 (First International Study of Infarct Survival) Collaborative Group.
    Lancet (London, England), 1988, Apr-23, Volume: 1, Issue:8591

    Topics: Atenolol; Clinical Trials as Topic; Coronary Disease; Heart Rupture; Humans; Ireland; Myocardial Inf

1988

Other Studies

27 other studies available for atenolol and Ventricular Fibrillation

ArticleYear
Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure.
    Epilepsia, 2018, Volume: 59, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Atenolol; Diazepam; Drug Therapy, Combination; Ele

2018
Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs.
    Heart rhythm, 2013, Volume: 10, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; Atenolol; Disease Models, Animal; Kidney; Male; Myocardial Reperfus

2013
Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation.
    The American journal of emergency medicine, 2008, Volume: 26, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Cardiopulmonary Resuscitation; Drug Therapy, Combina

2008
Arrhythmogenic effect of sympathetic histamine in mouse hearts subjected to acute ischemia.
    Molecular medicine (Cambridge, Mass.), 2012, Feb-10, Volume: 18

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atenolol; Famotidine; Heart; Heart Rate; Hist

2012
The protective effect of H2-receptor activation against the duration of myocardial hypoxia/reoxygenation-induced ventricular fibrillation in sensitized guinea-pig hearts.
    Journal of pharmacological sciences, 2005, Volume: 99, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Cytoplasmic Granules; Dimaprit; Electrocardiography;

2005
[Characteristics of action of various drugs blocking atrioventricular conduction (beta-blockers, verapamil, diltiazem) in constant fibrillation tachyarrhythmia. Is monotherapy optimal?].
    Terapevticheskii arkhiv, 2006, Volume: 78, Issue:8

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Atrioventricular Node; Calcium Channel Blockers;

2006
Endoscopic thoracic sympathectomy for long QT syndrome.
    Irish journal of medical science, 2008, Volume: 177, Issue:2

    Topics: Adrenergic beta-Antagonists; Atenolol; Defibrillators, Implantable; Electric Countershock; Female; H

2008
Sudden cardiac arrest in hypertrophic cardiomyopathy in the absence of conventional criteria for high risk status.
    The American journal of cardiology, 2008, Feb-15, Volume: 101, Issue:4

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Cardiomyopathy, Hypertrophic; Defibrillato

2008
Prolongation of the Q-T interval caused by sotalol--possible association with ventricular tachyarrhythmias.
    European heart journal, 1981, Volume: 2, Issue:4

    Topics: Adrenergic beta-Antagonists; Atenolol; Electrocardiography; Heart Ventricles; Humans; Kinetics; Male

1981
The effect of alpha- and beta-adrenoceptor antagonist agents on reperfusion ventricular fibrillation and metabolic status in the isolated perfused rat heart.
    Journal of the American College of Cardiology, 1983, Volume: 1, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Arterial Occlusive Diseases; Ate

1983
Antifibrillatory properties of the beta-adrenergic receptor antagonists, nadolol, sotalol, atenolol and propranolol, in the anesthetized dog.
    Pharmacology, 1984, Volume: 28, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Dogs; Dose-Response Relation

1984
Influence of propranolol isomers and atenolol on myocardial cyclic AMP, high energy phosphates and vulnerability to fibrillation after coronary artery ligation in the isolated rat heart.
    Cardiovascular research, 1981, Volume: 15, Issue:12

    Topics: Adenosine Triphosphate; Animals; Atenolol; Coronary Disease; Cyclic AMP; Heart; Male; Myocardium; Ph

1981
[Sympathetic ganglionitis in the hereditary syndrome of QT prolongation (Romano-Ward syndrome); intracardiac registration of after-potentials (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1982, Apr-30, Volume: 107, Issue:17

    Topics: Adult; Arrhythmias, Cardiac; Atenolol; Autonomic Nervous System Diseases; Autopsy; Electrocardiograp

1982
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disea

1995
Anti-arrhythmic efficacy of beta-adrenergic blockade during acute ischemia in myocardium with scar.
    The American journal of the medical sciences, 1994, Volume: 307, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Pressure; Disease Models, Animal; Dogs; Heart

1994
Unexpected interaction between beta-adrenergic blockade and heart rate variability before and after myocardial infarction. A longitudinal study in dogs at high and low risk for sudden death.
    Circulation, 1994, Volume: 90, Issue:2

    Topics: Animals; Atenolol; Autonomic Nervous System; Death, Sudden, Cardiac; Dogs; Heart; Heart Rate; Longit

1994
Beta-receptor blockade in preventing sudden death.
    European heart journal, 1993, Volume: 14, Issue:5

    Topics: Adrenergic beta-Antagonists; Atenolol; Death, Sudden, Cardiac; Humans; Metoprolol; Practolol; Sotalo

1993
Modulation of ventricular arrhythmias by catecholamines during evolving infarction in the isolated perfused rat heart.
    Proceedings of the Western Pharmacology Society, 2001, Volume: 44

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Catecholamines; Coronary Circulation; Electrocardiog

2001
The role of cyclic adenosine monophosphate in adrenergic effects on ventricular vulnerability to fibrillation in the isolated perfused rat heart.
    The Journal of clinical investigation, 1978, Volume: 61, Issue:5

    Topics: Adenosine Triphosphate; Animals; Atenolol; Bucladesine; Cyclic AMP; Epinephrine; Myocardium; Phospho

1978
Extracellular potassium activity changes in the canine myocardium after acute coronary occlusion and the influence of beta-blockade.
    Cardiovascular research, 1979, Volume: 13, Issue:5

    Topics: Animals; Atenolol; Coronary Disease; Dogs; Extracellular Space; Female; Heart; Male; Myocardium; Pot

1979
Prophylaxis of ventricular fibrillation after acute experimental coronary occlusion by chronic beta-adrenoceptor blockade with atenolol.
    Cardiovascular research, 1979, Volume: 13, Issue:10

    Topics: Animals; Arrhythmias, Cardiac; Atenolol; Dogs; Drug Administration Schedule; Heart Rate; Isoproteren

1979
[Effects of the beta-blocking agent atenolol on arrhythmias especially ventricular fibrillation and fibrillation threshold after acute experimental coronary artery occlusion (author's transl)].
    Zeitschrift fur Kardiologie, 1977, Volume: 66, Issue:7

    Topics: Animals; Arrhythmias, Cardiac; Atenolol; Carotid Arteries; Coronary Disease; Coronary Vessels; Dogs;

1977
Effects of metoprolol, alone and in combination with lidocaine, on ventricular fibrillation threshold: comparison with atenolol, propranolol, and pindolol.
    Journal of cardiovascular pharmacology, 1987, Volume: 9, Issue:5

    Topics: Animals; Atenolol; Differential Threshold; Dogs; Drug Combinations; Isoproterenol; Lidocaine; Metopr

1987
[The electrophysiologic effect of atenolol and nitrendipine on normal and ischemic rabbit myocardium in situ. III. Effects on ventricular fibrillation threshold].
    Zhonghua xin xue guan bing za zhi, 1989, Volume: 17, Issue:2

    Topics: Animals; Atenolol; Electric Stimulation; Electrophysiology; Female; Male; Myocardial Infarction; Nit

1989
Adrenergic effects on internal cardiac defibrillation threshold.
    The American journal of physiology, 1987, Volume: 253, Issue:3 Pt 2

    Topics: Animals; Atenolol; Blood Pressure; Dose-Response Relationship, Drug; Electric Countershock; Isoprote

1987
Hazards of combined beta-blocker/diuretic tablets.
    Lancet (London, England), 1985, May-25, Volume: 1, Issue:8439

    Topics: Antihypertensive Agents; Atenolol; Chlorthalidone; Drug Combinations; Female; Humans; Hypokalemia; M

1985
Ischemia- and reperfusion-induced arrhythmias in conscious rats--studies with prazosin and atenolol.
    Japanese circulation journal, 1988, Volume: 52, Issue:12

    Topics: Animals; Arrhythmias, Cardiac; Atenolol; Blood Pressure; Coronary Disease; Heart Rate; Male; Myocard

1988