atenolol has been researched along with Essential Hypertension in 4 studies
Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
atenolol : An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.
Essential Hypertension: Hypertension that occurs without known cause, or preexisting renal disease. Associated polymorphisms for a number of genes have been identified, including AGT, GNB3, and ECE1. OMIM: 145500
| Excerpt | Relevance | Reference |
|---|---|---|
| "Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study." | 7.81 | PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. ( Bailey, KR; Beitelshees, AL; Boerwinkle, E; Chapman, AB; Cooper-DeHoff, RM; Curry, RW; Donner, KM; El Rouby, N; Gong, Y; Gums, JG; Hall, K; Hiltunen, TP; Johnson, JA; Kontula, KK; Kubo, M; Langaee, TY; McDonough, CW; O'Connell, JR; Padmanabhan, S; Pepine, CJ; Schmidt, SO; Takahashi, A; Tanaka, T; Turner, ST, 2015) |
| "Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study." | 3.81 | PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. ( Bailey, KR; Beitelshees, AL; Boerwinkle, E; Chapman, AB; Cooper-DeHoff, RM; Curry, RW; Donner, KM; El Rouby, N; Gong, Y; Gums, JG; Hall, K; Hiltunen, TP; Johnson, JA; Kontula, KK; Kubo, M; Langaee, TY; McDonough, CW; O'Connell, JR; Padmanabhan, S; Pepine, CJ; Schmidt, SO; Takahashi, A; Tanaka, T; Turner, ST, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chapman, AB | 2 |
| Cotsonis, G | 1 |
| Parekh, V | 1 |
| Schwartz, GL | 1 |
| Gong, Y | 2 |
| Bailey, KR | 2 |
| Turner, ST | 2 |
| Gums, JG | 2 |
| Beitelshees, AL | 2 |
| Cooper-DeHoff, R | 1 |
| Boerwinkle, E | 2 |
| Johnson, JA | 2 |
| Zhou, WJ | 1 |
| Wang, RY | 1 |
| Li, Y | 1 |
| Chen, DR | 1 |
| Chen, EZ | 1 |
| Zhu, DL | 1 |
| Gao, PJ | 1 |
| Redón, J | 1 |
| Pascual-Izuel, JM | 1 |
| Rodilla, E | 1 |
| Vicente, A | 1 |
| Oliván, J | 1 |
| Bonet, J | 1 |
| Torguet, JP | 1 |
| Calaforra, O | 1 |
| Almirall, J | 1 |
| McDonough, CW | 1 |
| El Rouby, N | 1 |
| Hiltunen, TP | 1 |
| O'Connell, JR | 1 |
| Padmanabhan, S | 1 |
| Langaee, TY | 1 |
| Hall, K | 1 |
| Schmidt, SO | 1 |
| Curry, RW | 1 |
| Donner, KM | 1 |
| Kontula, KK | 1 |
| Takahashi, A | 1 |
| Tanaka, T | 1 |
| Kubo, M | 1 |
| Pepine, CJ | 1 |
| Cooper-DeHoff, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)[NCT00246519] | Phase 4 | 1,701 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| A Randomized Controlled Study: Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension[NCT01762436] | Phase 4 | 109 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00246519)
Timeframe: baseline to 18 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| Atenolol +HCTZ Arm | -12.06 |
| HCTZ + Atenolol | -13.33 |
3 trials available for atenolol and Essential Hypertension
| Article | Year |
|---|---|
Night blood pressure responses to atenolol and hydrochlorothiazide in black and white patients with essential hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Blood Pres | 2014 |
A randomized controlled study on the effects of bisoprolol and atenolol on sympathetic nervous activity and central aortic pressure in patients with essential hypertension.
Topics: Adult; Antihypertensive Agents; Arterial Pressure; Atenolol; Baroreflex; Bisoprolol; Essential Hyper | 2013 |
Effects of nebivolol and atenolol on central aortic pressure in hypertensive patients: a multicenter, randomized, double-blind study.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Benzopyrans; Blood Pressure; Double-Blind Method; Es | 2014 |
1 other study available for atenolol and Essential Hypertension
| Article | Year |
|---|---|
PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Black People; Blood Pre | 2015 |