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atenolol and Arteriosclerosis, Coronary

atenolol has been researched along with Arteriosclerosis, Coronary in 28 studies

Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
atenolol : An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.

Research Excerpts

ExcerptRelevanceReference
"To explore possible differential effects between metoprolol and atenolol in patients with coronary artery disease."9.16Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease. ( Aaberge, L; Ablad, B; Bjurö, T; Gullestad, L; Høglund, L; Kjekshus, E; Mellgård, AJ; Pernow, J; Skårdal, R; Wahlquist, I, 2012)
"In INternational VErapamil-trandolapril STudy, 22,576 CAD patients with hypertension (mean age 66 years) were randomized to verapamil-SR or atenolol-based strategies and followed for 2."9.14Pulse pressure and risk of cardiovascular outcomes in patients with hypertension and coronary artery disease: an INternational VErapamil SR-trandolapril STudy (INVEST) analysis. ( Bangalore, S; Champion, A; Franklin, SS; Mancia, G; Messerli, FH; Pepine, CJ, 2009)
" Fifteen male patients with stable angina pectoris treated with atenolol were studied after undergoing routine cardiac catheterisation."9.07A comparison of the acute haemodynamic effects of nisoldipine and nifedipine during treatment with atenolol in patients with coronary artery disease. ( Dawkins, KD; Donaldson, KM; Waller, DG, 1993)
"Trandolapril was also recommended for patients with heart failure, diabetes, or renal impairment."6.71A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. ( Bakris, GL; Bristol, HA; Cangiano, JL; Cohen, JD; Cooper-DeHoff, RM; Erdine, S; Garcia-Barreto, D; Handberg, EM; Keltai, M; Kolb, HR; Kowey, P; Mancia, G; Marks, RG; Messerli, FH; Parmley, WW; Pepine, CJ, 2003)
"We hypothesized that nebivolol, a β-blocker with nitric oxide-mediated activity, compared with atenolol, a β-blocker without such activity, would decrease oxidative stress and improve the effects of endothelial dysfunction and wall shear stress (WSS), thereby reducing atherosclerosis progression and vulnerability in patients with nonobstructive coronary artery disease."5.22Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double-Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary ( Ahn, SG; Corban, MT; Dhawan, S; Eshtehardi, P; Giddens, DP; Gogas, BD; Hung, OY; Maynard, C; McDaniel, MC; Molony, D; Piccinelli, M; Quyyumi, AA; Rasoul-Arzrumly, E; Samady, H; Timmins, LH, 2016)
"To explore possible differential effects between metoprolol and atenolol in patients with coronary artery disease."5.16Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease. ( Aaberge, L; Ablad, B; Bjurö, T; Gullestad, L; Høglund, L; Kjekshus, E; Mellgård, AJ; Pernow, J; Skårdal, R; Wahlquist, I, 2012)
"In INternational VErapamil-trandolapril STudy, 22,576 CAD patients with hypertension (mean age 66 years) were randomized to verapamil-SR or atenolol-based strategies and followed for 2."5.14Pulse pressure and risk of cardiovascular outcomes in patients with hypertension and coronary artery disease: an INternational VErapamil SR-trandolapril STudy (INVEST) analysis. ( Bangalore, S; Champion, A; Franklin, SS; Mancia, G; Messerli, FH; Pepine, CJ, 2009)
" Statistical modeling from INVEST (INternational VErapamil-Trandolapril STudy), suggests an association between dual and triple therapy and decreased risk of primary outcome ([PO] first occurrence of death, nonfatal MI, or nonfatal stroke) in patients with hypertension and coronary artery disease (CAD)."5.12Dual therapy in hypertensive patients with coronary artery disease: the role of calcium channel blockers and beta-blockers. ( Bakris, GL; Champion, A; Cooper-Dehoff, RM; Kupfer, S; Pepine, CJ; Zhou, Q, 2007)
"When antihypertensive treatment options are clinically equivalent, prescribers may first consider using a verapamil SR-based strategy, especially in patients with CAD who have no history of depression."5.12Depressive symptoms in coronary artery disease patients after hypertension treatment. ( Lopez, LM; Pepine, CJ; Ried, LD; Sauer, BC; Taylor, MD; Tueth, MJ, 2006)
" Fifteen male patients with stable angina pectoris treated with atenolol were studied after undergoing routine cardiac catheterisation."5.07A comparison of the acute haemodynamic effects of nisoldipine and nifedipine during treatment with atenolol in patients with coronary artery disease. ( Dawkins, KD; Donaldson, KM; Waller, DG, 1993)
"The US cohort of the International Verapamil SR-Trandolapril Study (INVEST), a randomized clinical trial of 16 688 patients aged 50 years or older with hypertension and coronary artery disease, was conducted between September 2, 1997, and December 15, 2000, with in-trial follow-up through February 14, 2003."4.02Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease: A Post Hoc Analysis of a Randomized Clinical Trial. ( Cooper-DeHoff, RM; Dasa, O; Gong, Y; Handberg, E; Howard, G; Pepine, CJ; Smith, SM, 2021)
" Metabolic dysregulation is a major contributor to coronary disease; therefore, we assessed LXRA in International Verapamil Sustained Release SR Trandolapril Study Genetic Substudy (INVEST-GENES), a genetic-substudy of a large clinical trial in patients with hypertension and coronary artery disease."3.77Liver X receptor α gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study. ( Cooper-DeHoff, RM; Johnson, JA; Martin, MA; Pacanowski, MA; Pepine, CJ; Price, ET; Zineh, I, 2011)
"7-year follow-up, compared a calcium antagonist-led strategy (verapamil SR plus trandolapril) with a beta-blocker-led strategy (atenolol plus hydrochlorothiazide) for hypertension treatment and prevention of cardiovascular outcomes in coronary artery disease patients."3.75INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study. ( Champion, A; Cooper-DeHoff, RM; Handberg, EM; Legler, UF; Mancia, G; Pepine, CJ; Zhou, Q, 2009)
"Trandolapril was also recommended for patients with heart failure, diabetes, or renal impairment."2.71A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. ( Bakris, GL; Bristol, HA; Cangiano, JL; Cohen, JD; Cooper-DeHoff, RM; Erdine, S; Garcia-Barreto, D; Handberg, EM; Keltai, M; Kolb, HR; Kowey, P; Mancia, G; Marks, RG; Messerli, FH; Parmley, WW; Pepine, CJ, 2003)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.57)18.2507
2000's20 (71.43)29.6817
2010's6 (21.43)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Dasa, O1
Smith, SM1
Howard, G1
Cooper-DeHoff, RM12
Gong, Y4
Handberg, E2
Pepine, CJ17
Denardo, SJ1
Farsang, C1
Keltai, M2
Szirmai, L1
Messerli, FH8
Bavry, AA1
Handberg, EM4
Mancia, G7
Hung, OY1
Molony, D1
Corban, MT1
Rasoul-Arzrumly, E1
Maynard, C1
Eshtehardi, P1
Dhawan, S1
Timmins, LH1
Piccinelli, M1
Ahn, SG1
Gogas, BD1
McDaniel, MC1
Quyyumi, AA1
Giddens, DP1
Samady, H1
Veeraputhiran, M1
Sundermeyer, M1
Bangalore, S2
Franklin, SS1
Champion, A6
Pacanowski, MA2
Zineh, I2
Johnson, JA4
Gerhard, T1
Ried, LD2
Bakris, GL4
Zhou, Q4
Kupfer, S4
Legler, UF1
Weber, MA1
Price, ET1
Martin, MA1
Gullestad, L1
Pernow, J1
Bjurö, T1
Aaberge, L1
Skårdal, R1
Kjekshus, E1
Høglund, L1
Mellgård, AJ1
Wahlquist, I1
Ablad, B1
Vandell, AG1
Lobmeyer, MT1
Gawronski, BE1
Langaee, TY1
Gums, JG1
Beitelshees, AL1
Turner, ST1
Chapman, AB1
Bailey, KR1
Boerwinkle, E1
Liggett, SB1
Hanania, G1
Haïat, R1
Olive, T1
Maalouf, B1
Michel, D1
Martelet, M1
Godard, S1
Donaldson, KM1
Dawkins, KD1
Waller, DG1
Merritt, JC1
Niebauer, M1
Tarakji, K1
Hammer, D1
Mills, RM1
Marks, RG1
Kowey, P1
Cangiano, JL1
Garcia-Barreto, D1
Erdine, S3
Bristol, HA1
Kolb, HR1
Cohen, JD2
Parmley, WW1
Gaxiola, E2
Cooper-DeHoff, R2
Huffman, JC1
Wulsin, LR1
Stern, TA1
Lekakis, JP1
Protogerou, A1
Papamichael, C1
Vamvakou, G1
Ikonomidis, I1
Iconomidis, I1
Fici, F1
Mavrikakis, M1
Kowey, PR1
Kolloch, RE1
Benetos, A3
Coca, A2
Sleight, P1
Conti, CR2
Hewkin, AC3
Tavazzi, L1
Tueth, MJ1
Taylor, MD1
Sauer, BC1
Lopez, LM1
Kolloch, R1
Uretsky, S1
Sagiv, M1
Ben-Sira, D1
Goldhammer, E1
Kuster, GM1
Amann, FW1
Neuenschwander, C1
Drexel, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
INternational VErapamil SR Trandolapril STudy[NCT00133692]Phase 422,000 participants Interventional1997-09-30Completed
The Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Artery Plaques in Patients With Moderate Coronary Artery Disease[NCT01230892]Phase 429 participants (Actual)Interventional2010-02-28Completed
Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)[NCT00246519]Phase 41,701 participants (Actual)Interventional2005-10-31Completed
A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multi-centre Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of Verapamil SR on Preservation of Beta-cell Function (Ver-A-T1D)[NCT04545151]Phase 2138 participants (Anticipated)Interventional2021-02-08Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Reduction of Thin-cap Fibroatheromas (TCFA) as Defined by VH-IVUS

Presence of thin-cap fibroatheroma as defined by virtual histology-intravascular ultrasound (VH-IVUS) (NCT01230892)
Timeframe: 1 year

Interventionparticipants (Number)
Nebivolol4
Atenolol6

Blood Pressure Response (Delta BP (After 18 Weeks of Medication - Baseline)).

(NCT00246519)
Timeframe: baseline to 18 weeks of treatment

InterventionmmHg (Mean)
Atenolol +HCTZ Arm-12.06
HCTZ + Atenolol-13.33

Trials

17 trials available for atenolol and Arteriosclerosis, Coronary

ArticleYear
Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: an international verapamil SR-trandolapril ambulatory monitoring substudy.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Coronary Artery Disease; Drug Therapy, Comb

2015
Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double-Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary
    Journal of the American Heart Association, 2016, Jan-25, Volume: 5, Issue:1

    Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Antagonists; Adult; Atenolol; Biomarkers; Coron

2016
Pulse pressure and risk of cardiovascular outcomes in patients with hypertension and coronary artery disease: an INternational VErapamil SR-trandolapril STudy (INVEST) analysis.
    European heart journal, 2009, Volume: 30, Issue:11

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Coronary Artery Disease; Coronary Disease;

2009
Genetic and pharmacogenetic associations between NOS3 polymorphisms, blood pressure, and cardiovascular events in hypertension.
    American journal of hypertension, 2009, Volume: 22, Issue:7

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Coronary Artery Disease; Female; Humans; Hy

2009
Systolic blood pressure and subjective well-being in patients with coronary artery disease.
    Clinical cardiology, 2009, Volume: 32, Issue:11

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Coronary Artery Disease; Drug Therapy, Comb

2009
Dual therapy in hypertensive patients with coronary artery disease: the role of calcium channel blockers and beta-blockers.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2007, Volume: 7 Suppl 1

    Topics: Adrenergic beta-Antagonists; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; A

2007
Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease.
    Scandinavian cardiovascular journal : SCJ, 2012, Volume: 46, Issue:1

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Angina, Stable; Atenolol; Blood Pressure; Coron

2012
[Coronary artery disease observed in general hospitals: ETTIC study. Comparison between trimetazidine and mononitrate isosorbide for patients receiving betablockers].
    Annales de cardiologie et d'angeiologie, 2002, Volume: 51, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Coronary Artery Disease; Drug Therapy, Combination; Exe

2002
A comparison of the acute haemodynamic effects of nisoldipine and nifedipine during treatment with atenolol in patients with coronary artery disease.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Atenolol; Blood Pressure; Calcium Channel

1993
A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial.
    JAMA, 2003, Dec-03, Volume: 290, Issue:21

    Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents

2003
Effect of nebivolol and atenolol on brachial artery flow-mediated vasodilation in patients with coronary artery disease.
    Cardiovascular drugs and therapy, 2005, Volume: 19, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Benzopyrans; Brachial Artery; Coronary Artery Disease;

2005
Depressive symptoms in coronary artery disease patients after hypertension treatment.
    The Annals of pharmacotherapy, 2006, Volume: 40, Issue:4

    Topics: Aged; Antihypertensive Agents; Atenolol; Coronary Artery Disease; Depression; Female; Humans; Male;

2006
Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?
    Annals of internal medicine, 2006, Jun-20, Volume: 144, Issue:12

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Cause of Death; Coronary Artery Disease; Di

2006
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
    The American journal of cardiology, 2006, Oct-01, Volume: 98, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann

2006
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
    The American journal of cardiology, 2006, Oct-01, Volume: 98, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann

2006
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
    The American journal of cardiology, 2006, Oct-01, Volume: 98, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann

2006
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
    The American journal of cardiology, 2006, Oct-01, Volume: 98, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann

2006
Obesity paradox in patients with hypertension and coronary artery disease.
    The American journal of medicine, 2007, Volume: 120, Issue:10

    Topics: Age Distribution; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Causality; Cohort Studie

2007
Beta-blockers, exercise, and the immune system in men with coronary artery disease.
    Medicine and science in sports and exercise, 2002, Volume: 34, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Atenolol; CD4-CD8 Ratio; Coronary Artery Disease; Exercise; Huma

2002
High density-lipoprotein subfractions of patients using cardio-selective beta-blockers.
    Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Apolipoproteins; Atenolol; Cholesterol; Cholesterol, HDL;

2002

Other Studies

11 other studies available for atenolol and Arteriosclerosis, Coronary

ArticleYear
Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease: A Post Hoc Analysis of a Randomized Clinical Trial.
    JAMA network open, 2021, 04-01, Volume: 4, Issue:4

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Coronary Artery Disease; Female; Humans; Hy

2021
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin.
    Clinical lung cancer, 2008, Volume: 9, Issue:4

    Topics: Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antihypertensiv

2008
INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study.
    Expert review of cardiovascular therapy, 2009, Volume: 7, Issue:11

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Coro

2009
Hypertension: BP reduction in patients with diabetes--uncertainties remain.
    Nature reviews. Cardiology, 2010, Volume: 7, Issue:11

    Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Calcium Channel Blockers; Coronary Artery Disease

2010
Liver X receptor α gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study.
    Pharmacogenetics and genomics, 2011, Volume: 21, Issue:6

    Topics: Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Channel Blockers; Case-Control Stu

2011
G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:4

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Blood Pressure; Calcium Channel Bloc

2012
Comparison of effectiveness of carvedilol versus metoprolol or atenolol for atrial fibrillation appearing after coronary artery bypass grafting or cardiac valve operation.
    The American journal of cardiology, 2003, Sep-15, Volume: 92, Issue:6

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Atenolol; Atrial Fibrillation; Carbazoles; Carvedilol; Coronary

2003
Clinical outcomes in the diabetes cohort of the INternational VErapamil SR-Trandolapril study.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 44, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents

2004
Newly diagnosed hypertension and depressive symptoms: how would you treat?
    The Journal of family practice, 2005, Volume: 54, Issue:1

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents; Antihypertensive Agents; Atenolol; Coronary Arte

2005
Predictors of adverse outcome among patients with hypertension and coronary artery disease.
    Journal of the American College of Cardiology, 2006, Feb-07, Volume: 47, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Blood Pressure; Calcium

2006
Predicting stroke risk in hypertensive patients with coronary artery disease: a report from the INVEST.
    Stroke, 2008, Volume: 39, Issue:2

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Black People; Coronary Artery Disease; D

2008