ataprost has been researched along with Asthma* in 1 studies
1 other study(ies) available for ataprost and Asthma
| Article | Year |
|---|---|
Effect of oral administration of a prostacyclin analog (OP-41483) on pulmonary function and bronchial responsiveness in stable asthmatic subjects.
To examine whether prostacyclin has an attenuating effect on nonspecific bronchial responsiveness in asthma, we measured provocative concentration of methacholine producing a 20% fall in forced expiratory volume in 1 second (PC20-FEV1) before and after oral administration of a chemically stable prostacyclin analog (OP-41483) (200 micrograms 4 times a day for 4 days) in 8 patients with stable asthma. Neither baseline pulmonary function nor PC20-FEV1 significantly improved after the treatment. These results suggest that prostacyclin may have no direct effect on bronchial responsiveness in asthmatics. Further studies using more potent and long-lasting prostacyclin mimetic will be needed to confirm the conclusion. Topics: Acetylcholine; Administration, Oral; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Epoprostenol; Forced Expiratory Volume; Humans; Middle Aged; Prostaglandins, Synthetic | 1991 |