at-7519 and Carcinoma--Pancreatic-Ductal

at-7519 has been researched along with Carcinoma--Pancreatic-Ductal* in 1 studies

Other Studies

1 other study(ies) available for at-7519 and Carcinoma--Pancreatic-Ductal

Article	Year
Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy. Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24 We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor. Topics: Amination; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Humans; Molecular Docking Simulation; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Structure-Activity Relationship	2018

Article

Year

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy.

Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24

We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor.

Topics: Amination; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Humans; Molecular Docking Simulation; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Structure-Activity Relationship

2018