astragaloside a has been researched along with Cirrhosis in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 14 (51.85) | 24.3611 |
| 2020's | 12 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C; Li, J; Lian, Y; Liu, Q; Meng, L; Shi, W; Wu, M; Xie, Y | 1 |
| Cao, WF; Chen, ZW; Du, XQ; Hu, JY; Shi, LP; Xiong, Y; Zuo, B | 1 |
| Hu, Y; Hu, Z; Liu, W; Pan, C; Tang, W | 1 |
| Cheng, Y; Lin, H; Xiang, Z; Xiao, Q; Yu, X | 1 |
| Hao, YK; Li, YY; Shi, JJ; Su, SS; Tian, ZH; Zhang, FR; Zhang, LH; Zhou, C | 1 |
| Cao, W; He, Q; Li, D; Liu, Y; Peng, Z; Tan, Q; Wang, J; Wang, S; Zeng, Y; Zhan, Q | 1 |
| Fu, Z; Jia, Q; Sun, Z; Wang, X; Xia, J; Xue, L; Zhang, L; Zhou, L | 1 |
| Li, R; Liu, D; Ma, Y; Xi, J | 1 |
| Feng, K; Tang, Y; Tao, R; Wei, Y; Wu, Y; Xu, H; Zhao, Y | 1 |
| Ji, T; Li, W; Wang, Z; Zhang, J; Zhang, Y; Zhu, Y | 1 |
| Chen, Y; Han, M; Jiang, S; Jiao, G; Liu, W; Wang, X | 1 |
| Cao, W; Jiang, J; Tao, C; Xuan, C; Zhang, Y | 1 |
| Dai, H; Jia, G; Leng, B; Wang, H | 1 |
| Bian, ZP; Chen, XJ; Ding, YZ; Gu, CR; Li, XZ; Wu, HF; Xu, JD; Yang, D | 1 |
| Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M | 1 |
| Gao, Y; Shi, Y; Tian, N; Wang, X; Zhang, N; Zou, D | 1 |
| Cao, X; Du, N; Gao, M; Liu, P; Sun, B; Xu, Z | 1 |
| Chen, Q; Ji, T; Ju, Y; Li, W; Ma, K; Su, Y; Wang, Z | 1 |
| Cai, H; Chi, YF; Peng, W; Wang, L; Yin, PH; Yuan, ZT; Zhang, XM; Zhou, WC | 1 |
| Gu, L; Mou, S; Ni, Z; Shao, X; Tian, L; Wang, L; Wang, Q; Wu, B; Xu, W; Xu, X; Yao, J; Zhang, M | 1 |
| Cha, X; Li, D; Mao, Y; Qi, Q; Yi, J; Zhu, K | 1 |
| Che, X; Mou, S; Ni, Z; Shao, X; Wang, Q; Xie, Y; Xu, W | 1 |
| Chen, C; Gong, X; Shan, G; Sun, X; Yang, Y; Yao, Q; Zhou, X | 1 |
| Dai, H; Jia, G; Liang, C; Lu, M; Wang, H; Wang, Y | 1 |
| Chen, Z; Du, Q; Huang, M; Yin, KS; Zhang, Q; Zhou, LF | 1 |
| Cai, SQ; Li, XM; Liu, SY; Meng, LQ; Qu, L; Shang, MY; Tang, JW; Wang, Y; Zhang, M; Zhao, JR | 1 |
| Chen, H; Chen, P; Chen, R; Ge, J; Li, GG; Shen, E; Xie, Y; Yang, Y; Yu, Y; Zhang, CB; Zou, Y | 1 |
27 other study(ies) available for astragaloside a and Cirrhosis
| Article | Year |
|---|---|
Astragaloside IV attenuated TGF-β1- induced epithelial-mesenchymal transition of renal tubular epithelial cells via connexin 43 and Akt/mTOR signaling pathway.
Topics: Connexin 43; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Kidney Diseases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1; Triterpenes | 2022 |
Astragaloside IV Ameliorates Isoprenaline-Induced Cardiac Fibrosis in Mice
Topics: Akkermansia; Amino Acids; Animals; Bacteroidetes; Feces; Fibrosis; Gastrointestinal Microbiome; Isoproterenol; Male; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Saponins; Triterpenes | 2022 |
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Topics: Animals; Chemokine CX3CL1; Diabetes Mellitus; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Fibrosis; Hyperglycemia; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Saponins; Signal Transduction; Triterpenes | 2022 |
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Glycogen Synthase Kinase 3 beta; Kidney Diseases; Molecular Docking Simulation; Network Pharmacology; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Saponins; Signal Transduction; Transforming Growth Factor beta1; Triterpenes | 2022 |
Anti-apoptotic effect of HeidihuangWan in renal tubular epithelial cells via PI3K/Akt/mTOR signaling pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Epithelial Cells; Fibrosis; Kidney Diseases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2023 |
Astragaloside IV Blunts Epithelial-Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Fibrosis; G2 Phase Cell Cycle Checkpoints; Humans; Molecular Docking Simulation; Proto-Oncogene Proteins c-akt; Rats; Renal Insufficiency, Chronic; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1; Tumor Suppressor Protein p53 | 2023 |
Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells.
Topics: Animals; Drugs, Chinese Herbal; Emodin; Fibrosis; Kidney; Kidney Failure, Chronic; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2023 |
Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension through the PHD2/HIF1α signaling pathway.
Topics: Animals; Cell Proliferation; Fibrosis; Hypertension, Pulmonary; Hypoxia; Myocytes, Smooth Muscle; Prolyl Hydroxylases; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyroptosis; Rats; Signal Transduction | 2023 |
Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.
Topics: Animals; Animals, Newborn; Astragalus Plant; Cardiomyopathy, Hypertrophic; Cells, Cultured; Disease Models, Animal; Fibrosis; Humans; Isoproterenol; Male; Medicine, Chinese Traditional; MicroRNAs; Myocardium; Myofibroblasts; Plant Extracts; Plant Roots; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Triterpenes; TRPM Cation Channels | 2020 |
Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diet, High-Fat; Fibrosis; Inflammation; Lipid Metabolism; Male; Myocardium; Rats; Saponins; Triterpenes | 2020 |
Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca
Topics: Animals; Apoptosis; Calcium; Echocardiography; Fibrosis; Heart; Homeostasis; Hypoxia; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sleep Apnea, Obstructive; Triterpenes | 2020 |
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Topics: Animals; Collagen Type IV; Cytokines; Diabetic Nephropathies; Fibronectins; Fibrosis; Gene Expression Profiling; Glycation End Products, Advanced; Inflammation; Inflammation Mediators; Male; NLR Proteins; Podocytes; Protective Agents; Rats, Sprague-Dawley; Saponins; Signal Transduction; Transcription, Genetic; Triterpenes | 2020 |
Inhibition of cardiotrophin‑1 overexpression is involved in the anti‑fibrotic effect of Astrogaloside IV.
Topics: Animals; Cell Proliferation; Cells, Cultured; Collagen Type I; Cytokines; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Male; Myocardium; Myofibroblasts; Rats; Reactive Oxygen Species; RNA Interference; Saponins; Triterpenes | 2017 |
Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress.
Topics: Animals; Apolipoproteins E; Apoptosis; Cardiomegaly; Cardiotonic Agents; Female; Fibrosis; Gene Deletion; Hypercholesterolemia; Lipids; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Saponins; Transcriptome; Triterpenes; Ventricular Dysfunction, Left | 2017 |
Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.
Topics: Animals; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Fibroblasts; Fibrosis; Heart; Humans; Inflammasomes; Isoproterenol; Male; Mice; Mice, Inbred BALB C; Myocardium; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins; Triterpenes | 2018 |
Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice.
Topics: Animals; Cell Dedifferentiation; Diabetic Nephropathies; Fibrosis; Kidney; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; MicroRNAs; Podocytes; Saponins; Triterpenes | 2018 |
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy.
Topics: Administration, Oral; Animals; Central Nervous System Agents; Diabetic Nephropathies; Drugs, Chinese Herbal; Fibrosis; Ginsenosides; Male; Oxidative Stress; Rats; Rats, Wistar; Saponins; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Triterpenes | 2018 |
Astragaloside IV inhibits palmitate-mediated oxidative stress and fibrosis in human glomerular mesangial cells via downregulation of CD36 expression.
Topics: Animals; CD36 Antigens; Diabetic Nephropathies; Diet, High-Fat; Down-Regulation; Fatty Acids, Nonesterified; Fibrosis; Humans; Male; Mesangial Cells; Oxidative Stress; Palmitates; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Transforming Growth Factor beta1; Triterpenes | 2019 |
Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro.
Topics: Animals; Disease Models, Animal; Fibrosis; Gene Expression Profiling; Kidney; Kidney Diseases; Kidney Function Tests; Rats, Sprague-Dawley; Saponins; Severity of Illness Index; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta; Triterpenes | 2014 |
Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro.
Topics: Animals; Apoptosis; Fibrosis; Humans; Kidney Diseases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Saponins; Triterpenes | 2014 |
Anti-fibrotic effects of Astragaloside IV in systemic sclerosis.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Mice; RNA, Messenger; Saponins; Scleroderma, Systemic; Smad3 Protein; Transforming Growth Factor beta; Triterpenes | 2014 |
Astragaloside IV suppresses transforming growth factor-β1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-κB signaling pathways.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fibroblasts; Fibrosis; Kidney; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Saponins; Transforming Growth Factor beta1; Triterpenes | 2015 |
Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro.
Topics: Animals; Anti-Inflammatory Agents; Astragalus propinquus; Cell Line; Fibrosis; Humans; Inflammation; Kidney; Kidney Diseases; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; NF-kappa B; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes; Ureteral Obstruction | 2017 |
Astragaloside IV inhibits isoprenaline‑induced cardiac fibrosis by targeting the reactive oxygen species/mitogen‑activated protein kinase signaling axis.
Topics: Animals; Astragalus Plant; Cell Proliferation; Collagen Type I; Female; Fibroblasts; Fibrosis; Heart; Isoproterenol; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Myocardium; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2017 |
Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.
Topics: Actins; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Chronic Disease; Collagen; Cytokines; Female; Fibrosis; Hydroxyproline; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Saponins; Th2 Cells; Transforming Growth Factor beta1; Triterpenes | 2008 |
Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy.
Topics: Animals; Cell Transdifferentiation; Cells, Cultured; Coumaric Acids; Drug Synergism; Fibroblasts; Fibrosis; Humans; Kidney; Kidney Tubules, Proximal; Male; Nephritis, Interstitial; Nitric Oxide; Phosphorylation; Rats; Rats, Wistar; Saponins; Triterpenes; Ureteral Obstruction | 2011 |
Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy.
Topics: Animals; Cardiomyopathy, Dilated; Collagen; Down-Regulation; Enterovirus B, Human; Fibrosis; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Saponins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Triterpenes | 2011 |