astragalin and Cognitive-Dysfunction

astragalin has been researched along with Cognitive-Dysfunction* in 1 studies

Other Studies

1 other study(ies) available for astragalin and Cognitive-Dysfunction

Article	Year
Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression. Metabolic brain disease, 2022, Volume: 37, Issue:8 Senile plaques composed of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) composed of intracellular hyper-phosphorylated tau are major causes of cognitive impairment and neuronal damage in Alzheimer disease (AD). Astragalin (AST), a naturally-occurring flavonoid compound, was reported to have neuroprotective effects in the brain, but its effects in AD remain unknown. Herein, the learning and memory deficits were alleviated and neuronal damage in the hippocampus were inhibited after the senescence-accelerated mouse prone 8 (SAMP8) mouse were given AST (5 mg/kg or 10 mg/kg) daily by gavage for 2 months. Furthermore, AST reduced Aβ Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Estrogen Receptor beta; Glycogen Synthase Kinase 3 beta; Hippocampus; Maze Learning; Mice; Neurons; Phosphorylation; Receptors, Estrogen; tau Proteins	2022

Article

Year

Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression.

Metabolic brain disease, 2022, Volume: 37, Issue:8

Senile plaques composed of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) composed of intracellular hyper-phosphorylated tau are major causes of cognitive impairment and neuronal damage in Alzheimer disease (AD). Astragalin (AST), a naturally-occurring flavonoid compound, was reported to have neuroprotective effects in the brain, but its effects in AD remain unknown. Herein, the learning and memory deficits were alleviated and neuronal damage in the hippocampus were inhibited after the senescence-accelerated mouse prone 8 (SAMP8) mouse were given AST (5 mg/kg or 10 mg/kg) daily by gavage for 2 months. Furthermore, AST reduced Aβ

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Estrogen Receptor beta; Glycogen Synthase Kinase 3 beta; Hippocampus; Maze Learning; Mice; Neurons; Phosphorylation; Receptors, Estrogen; tau Proteins

2022