astragalin has been researched along with Asthma* in 1 studies
1 other study(ies) available for astragalin and Asthma
Article | Year |
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Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model.
The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovered in bronchoalveolar lavage fluid, and increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that AG substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model. Our findings support the possible use of AG as a therapeutic drug for patients with allergic asthma. Topics: Animals; Anti-Inflammatory Agents; Asthma; Female; Inflammation; Inflammation Mediators; Kaempferols; Mice; Mice, Inbred BALB C; Ovalbumin | 2015 |