astin-c and Inflammation
astin-c has been researched along with Inflammation* in 1 studies
Other Studies
1 other study(ies) available for astin-c and Inflammation
Article | Year |
---|---|
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify effective lead compounds that specifically downregulate the pathway. We report here that astin C, a cyclopeptide isolated from the medicinal plant Aster tataricus, inhibits cGAS-STING signaling and the innate inflammatory responses triggered by cytosolic DNAs. Moreover, mice treated with astin C are more susceptible to HSV-1 infection. Consistently, astin C markedly attenuates the autoinflammatory responses in Trex1 Topics: Animals; Anti-Infective Agents; Autoimmune Diseases; Cytosol; DNA; Female; Gene Expression Regulation; HEK293 Cells; Herpesvirus 1, Human; Humans; Immunity, Innate; Inflammation; Interferon Regulatory Factor-3; Listeria monocytogenes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nucleotides; Peptides, Cyclic; RAW 264.7 Cells; Signal Transduction | 2018 |