astemizole has been researched along with Urticaria in 35 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cetirizine and astemizole have been shown to be safe and effective in the treatment of patients with chronic idiopathic urticaria." | 9.08 | Cetirizine and astemizole therapy for chronic idiopathic urticaria: a double-blind, placebo-controlled, comparative trial. ( Breneman, D; Bronsky, EA; Bruce, S; Kalivas, JT; Klein, GL; Roth, HL; Soter, N; Tharp, MD; Treger, C, 1995) |
| "A double-blind clinical trial of 51 patients with chronic idiopathic urticaria using oral astemizole for 8 weeks demonstrated significant improvement in symptoms and lesions in 75% of treated patients versus 20% in the placebo group." | 9.06 | Prolonged benefit in the treatment of chronic idiopathic urticaria with astemizole. ( Honsinger, RW; Thomsen, RJ, 1990) |
| "Forty patients with chronic urticaria were treated with terfenadine or astemizole in a randomized double-blind study." | 9.06 | Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients. ( Bödeker, RH; Paul, E, 1989) |
| "Astemizole is a new, long-acting H1 receptor antagonist that has proven effective in controlling the signs and symptoms of chronic idiopathic urticaria, without the sedative and anticholinergic side effects that typify use of many antihistamines." | 9.06 | Treatment of chronic idiopathic urticaria with astemizole. ( Bergfeld, WF; Dijkstra, JW; Huerter, CJ; Wagner, WO, 1989) |
| "Astemizole, one of the newer generation of nonsedating antihistamines, was evaluated in a double-blind study of forty-six patients who had chronic idiopathic urticaria with or without angioedema; most had severe disease." | 9.06 | Controlled clinical assessment of astemizole in the treatment of chronic idiopathic urticaria and angioedema. ( Kailasam, V; Mathews, KP, 1987) |
| "Two new non-sedating antihistamines, astemizole (10 mg per day) and terfenadine (120 mg per day), were compared in a double-blind randomized study in 42 adult patients suffering from chronic urticaria." | 9.06 | Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria. ( Cainelli, T; Mosca, M; Seidenari, S; Valsecchi, R, 1986) |
| "In the course of a multicenter study on 2122 patients treated by 412 dermatologists in general practice, we investigated the effect of astemizole (Hismanal) on urticaria." | 9.06 | [Astemizole in urticaria--a multicenter study by 412 established dermatologists]. ( Kurz, K; Oestreich, W, 1987) |
| "The efficacy and safety of astemizole (AST), a new long-acting H1 antagonist with minimal sedative or anticholinergic side effects, were studied in an 8-week double-blind trial of 51 patients with chronic idiopathic urticaria." | 9.06 | Efficacy and safety of astemizole, a long-acting and nonsedating H1 antagonist for the treatment of chronic idiopathic urticaria. ( Bernstein, DI; Bernstein, IL, 1986) |
| "40 patients suffering from chronic urticaria were randomly treated with either Terfenadine or Astemizole." | 9.05 | [Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients]. ( Bödeker, RH; Paul, E, 1985) |
| "Three cases of solar urticaria in the visible spectrum successfully treated with astemizole, a H1 antihistamine, are reported." | 7.68 | Solar urticaria in the visible spectrum successfully treated with astemizole. ( Monfrecola, G; Nappa, P; Pini, D, 1990) |
| "20 patients, 12 suffering from chronic urticaria, 2 from acute urticaria, 1 from pressure urticaria, 2 from cold urticaria and 3 from urticaria factitia were treated in an open pilot study with the new H1-antihistamine Astemizole." | 7.67 | [Treatment of urticaria with the new H1 antihistaminic astemizole--with special reference to the time of onset of effect and maximum effect]. ( Kurz, K, 1986) |
| "An open multicentric pediatric clinical trial has been performed to evaluate the safety and efficacy of astemizole (HISMANAL suspension) at a 1 ml (2 mg) dosage per 10 kg body weight once daily in children with chronic urticaria." | 7.67 | [Treatment of chronic urticaria with astemizole: a multicenter pediatric study]. ( Guinnepain, MT, 1987) |
| "Treatment with astemizole, as measured at the end point of each patient's treatment and compared to placebo, resulted in significant improvement of pruritus, erythema, number of wheals, frequency of urticarial attacks, and control of urticaria (p less than or equal to 0." | 6.66 | The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials. ( Bukantz, SC; Fox, RW; Lockey, RF; Serbousek, D, 1986) |
| "Cetirizine and astemizole have been shown to be safe and effective in the treatment of patients with chronic idiopathic urticaria." | 5.08 | Cetirizine and astemizole therapy for chronic idiopathic urticaria: a double-blind, placebo-controlled, comparative trial. ( Breneman, D; Bronsky, EA; Bruce, S; Kalivas, JT; Klein, GL; Roth, HL; Soter, N; Tharp, MD; Treger, C, 1995) |
| "The efficacy of astemizole, diphenhydramine, and hydroxyzine hydrochloride in the treatment of chronic idiopathic urticaria was evaluated in this 3-month double-blind, randomized, parallel group study." | 5.07 | Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria. ( Jancelewicz, Z; Sussman, G, 1991) |
| "A double-blind clinical trial of 51 patients with chronic idiopathic urticaria using oral astemizole for 8 weeks demonstrated significant improvement in symptoms and lesions in 75% of treated patients versus 20% in the placebo group." | 5.06 | Prolonged benefit in the treatment of chronic idiopathic urticaria with astemizole. ( Honsinger, RW; Thomsen, RJ, 1990) |
| "Forty patients with chronic urticaria were treated with terfenadine or astemizole in a randomized double-blind study." | 5.06 | Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients. ( Bödeker, RH; Paul, E, 1989) |
| "Astemizole is a new, long-acting H1 receptor antagonist that has proven effective in controlling the signs and symptoms of chronic idiopathic urticaria, without the sedative and anticholinergic side effects that typify use of many antihistamines." | 5.06 | Treatment of chronic idiopathic urticaria with astemizole. ( Bergfeld, WF; Dijkstra, JW; Huerter, CJ; Wagner, WO, 1989) |
| "Astemizole, one of the newer generation of nonsedating antihistamines, was evaluated in a double-blind study of forty-six patients who had chronic idiopathic urticaria with or without angioedema; most had severe disease." | 5.06 | Controlled clinical assessment of astemizole in the treatment of chronic idiopathic urticaria and angioedema. ( Kailasam, V; Mathews, KP, 1987) |
| "Two new non-sedating antihistamines, astemizole (10 mg per day) and terfenadine (120 mg per day), were compared in a double-blind randomized study in 42 adult patients suffering from chronic urticaria." | 5.06 | Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria. ( Cainelli, T; Mosca, M; Seidenari, S; Valsecchi, R, 1986) |
| "In the course of a multicenter study on 2122 patients treated by 412 dermatologists in general practice, we investigated the effect of astemizole (Hismanal) on urticaria." | 5.06 | [Astemizole in urticaria--a multicenter study by 412 established dermatologists]. ( Kurz, K; Oestreich, W, 1987) |
| "The efficacy and safety of astemizole (AST), a new long-acting H1 antagonist with minimal sedative or anticholinergic side effects, were studied in an 8-week double-blind trial of 51 patients with chronic idiopathic urticaria." | 5.06 | Efficacy and safety of astemizole, a long-acting and nonsedating H1 antagonist for the treatment of chronic idiopathic urticaria. ( Bernstein, DI; Bernstein, IL, 1986) |
| "40 patients suffering from chronic urticaria were randomly treated with either Terfenadine or Astemizole." | 5.05 | [Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients]. ( Bödeker, RH; Paul, E, 1985) |
| "The second-generation H1-receptor antagonists terfenadine, astemizole, loratadine, and cetirizine are important first-line drugs for the relief of symptoms in patients with allergic rhinoconjunctivitis or chronic urticaria and may eventually supplant the potentially sedating first-generation H1-receptor antagonists in the treatment of these disorders." | 4.78 | Recent advances in H1-receptor antagonist treatment. ( Simons, FE, 1990) |
| "Three cases of solar urticaria in the visible spectrum successfully treated with astemizole, a H1 antihistamine, are reported." | 3.68 | Solar urticaria in the visible spectrum successfully treated with astemizole. ( Monfrecola, G; Nappa, P; Pini, D, 1990) |
| "20 patients, 12 suffering from chronic urticaria, 2 from acute urticaria, 1 from pressure urticaria, 2 from cold urticaria and 3 from urticaria factitia were treated in an open pilot study with the new H1-antihistamine Astemizole." | 3.67 | [Treatment of urticaria with the new H1 antihistaminic astemizole--with special reference to the time of onset of effect and maximum effect]. ( Kurz, K, 1986) |
| "An open multicentric pediatric clinical trial has been performed to evaluate the safety and efficacy of astemizole (HISMANAL suspension) at a 1 ml (2 mg) dosage per 10 kg body weight once daily in children with chronic urticaria." | 3.67 | [Treatment of chronic urticaria with astemizole: a multicenter pediatric study]. ( Guinnepain, MT, 1987) |
| "The effect of astemizole on the weal and flare response to intradermal histamine has been studied in normal volunteers after single dosing, and in patients with urticaria and pruritus after chronic dosing with the drug." | 3.66 | The effects of astemizole on histamine-induced weal and flare. ( Bateman, DN; Chapman, PH; Rawlins, MD, 1983) |
| "Astemizole was superior to placebo and the classical antihistamines like Clemastine, Terfenadine, Ketotifen, Mequitazine, pheniramine and Chlorphenamine." | 2.66 | [Total review of all results collected worldwide with astemizole (Hismanal)]. ( Rombaut, N; Vanden Bussche, G, 1985) |
| "Treatment with astemizole, as measured at the end point of each patient's treatment and compared to placebo, resulted in significant improvement of pruritus, erythema, number of wheals, frequency of urticarial attacks, and control of urticaria (p less than or equal to 0." | 2.66 | The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials. ( Bukantz, SC; Fox, RW; Lockey, RF; Serbousek, D, 1986) |
| "Astemizole is a long-acting, highly selective histamine1-receptor antagonist with minimal central and anticholinergic effects." | 2.37 | Astemizole: a long-acting, nonsedating antihistamine. ( Cluxton, RJ; Krstenansky, PM, 1987) |
| "Astemizole is a non-sedative and non-toxic drug, even during chronic use." | 1.27 | [General review of a non-sedative antihistaminic, astemizole (Hismanal), a H1 receptor antagonist]. ( Molkhou, P, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (60.00) | 18.7374 |
| 1990's | 14 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bateman, DN | 1 |
| Chapman, PH | 1 |
| Rawlins, MD | 1 |
| Krause, LB | 2 |
| Shuster, S | 3 |
| Breneman, D | 1 |
| Bronsky, EA | 1 |
| Bruce, S | 1 |
| Kalivas, JT | 1 |
| Klein, GL | 1 |
| Roth, HL | 1 |
| Tharp, MD | 1 |
| Treger, C | 1 |
| Soter, N | 1 |
| Goldsmith, P | 1 |
| Dowd, PM | 1 |
| Leenutaphong, V | 1 |
| Bernhard, JD | 1 |
| Martínez-Escribano, JA | 1 |
| Quecedo, E | 1 |
| De la Cuadra, J | 1 |
| Frías, J | 1 |
| Sánchez-Pedreño, P | 1 |
| Aliaga, A | 1 |
| Nichols, AW | 1 |
| Soter, NA | 1 |
| Lin, AY | 1 |
| Zahtz, G | 1 |
| Myssiorek, D | 1 |
| Sussman, G | 1 |
| Jancelewicz, Z | 1 |
| Monfrecola, G | 1 |
| Nappa, P | 1 |
| Pini, D | 1 |
| Honsinger, RW | 1 |
| Thomsen, RJ | 1 |
| Simons, FE | 2 |
| McMillan, JL | 1 |
| Simons, KJ | 1 |
| Lobaton, P | 1 |
| Moreno, F | 1 |
| Coulie, P | 1 |
| Paul, E | 2 |
| Bödeker, RH | 2 |
| Huerter, CJ | 1 |
| Bergfeld, WF | 1 |
| Wagner, WO | 1 |
| Dijkstra, JW | 1 |
| Rombaut, N | 2 |
| Vanden Bussche, G | 2 |
| Kurz, K | 2 |
| Emanuel, MB | 1 |
| Kailasam, V | 1 |
| Mathews, KP | 1 |
| Cainelli, T | 1 |
| Seidenari, S | 1 |
| Valsecchi, R | 1 |
| Mosca, M | 1 |
| Ray, JA | 1 |
| Krstenansky, PM | 1 |
| Cluxton, RJ | 1 |
| Oestreich, W | 1 |
| Molkhou, P | 1 |
| Forck, G | 1 |
| Bernstein, IL | 1 |
| Bernstein, DI | 1 |
| Fox, RW | 1 |
| Lockey, RF | 1 |
| Bukantz, SC | 1 |
| Serbousek, D | 1 |
| Guinnepain, MT | 1 |
4 reviews available for astemizole and Urticaria
| Article | Year |
|---|---|
The new H1 antihistamines. Treatment of urticaria and other clinical problems.
Topics: Astemizole; Cetirizine; Dermatitis, Atopic; Histamine H1 Antagonists; Humans; Loratadine; Terfenadin | 1993 |
Exercise-induced anaphylaxis and urticaria.
Topics: Anaphylaxis; Astemizole; Clemastine; Exercise; Humans; Terfenadine; Urticaria | 1992 |
Recent advances in H1-receptor antagonist treatment.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonis | 1990 |
Astemizole: a long-acting, nonsedating antihistamine.
Topics: Animals; Astemizole; Benzimidazoles; Histamine H1 Antagonists; Humans; Rhinitis; Urticaria | 1987 |
17 trials available for astemizole and Urticaria
| Article | Year |
|---|---|
H1-receptor-active histamine not sole cause of chronic idiopathic urticaria.
Topics: Astemizole; Benzimidazoles; Chronic Disease; Histamine; Histamine H1 Antagonists; Humans; Urticaria | 1984 |
Cetirizine and astemizole therapy for chronic idiopathic urticaria: a double-blind, placebo-controlled, comparative trial.
Topics: Adult; Astemizole; Cetirizine; Double-Blind Method; Drug Administration Schedule; Female; Humans; Ma | 1995 |
Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria.
Topics: Adult; Aged; Astemizole; Chronic Disease; Diphenhydramine; Dose-Response Relationship, Drug; Double- | 1991 |
Prolonged benefit in the treatment of chronic idiopathic urticaria with astemizole.
Topics: Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Histamin | 1990 |
A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects.
Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Cyproheptadin | 1990 |
Comparison of cetirizine with astemizole in the treatment of perennial allergic rhinitis and study of the concomitant effect on histamine and allergen-induced wheal responses.
Topics: Adult; Astemizole; Benzimidazoles; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Humans | 1990 |
Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double- | 1989 |
Treatment of chronic idiopathic urticaria with astemizole.
Topics: Adolescent; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Female; Histamine | 1989 |
[Total review of all results collected worldwide with astemizole (Hismanal)].
Topics: Astemizole; Beclomethasone; Benzimidazoles; Bronchitis; Clinical Trials as Topic; Conjunctivitis; Do | 1985 |
[Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients].
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double- | 1985 |
Clinical profile of astemizole. A survey of 50 double-blind trials.
Topics: Astemizole; Benzimidazoles; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; | 1987 |
Controlled clinical assessment of astemizole in the treatment of chronic idiopathic urticaria and angioedema.
Topics: Adult; Angioedema; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double-Bli | 1987 |
Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria.
Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Double-Blind M | 1986 |
[Astemizole in urticaria--a multicenter study by 412 established dermatologists].
Topics: Administration, Oral; Adult; Astemizole; Benzimidazoles; Clinical Trials as Topic; Female; Histamine | 1987 |
Efficacy and safety of astemizole, a long-acting and nonsedating H1 antagonist for the treatment of chronic idiopathic urticaria.
Topics: Adult; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Consumer Behavior; Dou | 1986 |
The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials.
Topics: Adolescent; Adult; Aged; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Doub | 1986 |
A comparison of astemizole and chlorpheniramine in dermographic urticaria.
Topics: Adolescent; Adult; Aged; Astemizole; Benzimidazoles; Chlorpheniramine; Clinical Trials as Topic; Dou | 1985 |
14 other studies available for astemizole and Urticaria
| Article | Year |
|---|---|
The effects of astemizole on histamine-induced weal and flare.
Topics: Adult; Aged; Astemizole; Benzimidazoles; Drug Hypersensitivity; Drug Interactions; Female; Histamine | 1983 |
Solar urticaria induced by UVA and inhibited by visible light.
Topics: Adolescent; Astemizole; Dose-Response Relationship, Radiation; Female; Humans; Radiation Injuries; S | 1993 |
Treatment of solar urticaria with terfenadine.
Topics: Astemizole; Humans; Sunlight; Terfenadine; Urticaria | 1993 |
Treatment of aquagenic urticaria with PUVA and astemizole.
Topics: Adult; Anti-Allergic Agents; Astemizole; Erythema; Female; Humans; Pruritus; PUVA Therapy; Urticaria | 1997 |
Treatment of urticaria and angioedema: low-sedating H1-type antihistamines.
Topics: Angioedema; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine | 1991 |
Astemizole-associated urinary retention.
Topics: Adult; Astemizole; Benzimidazoles; Common Cold; Histamine H1 Antagonists; Humans; Male; Middle Aged; | 1991 |
Solar urticaria in the visible spectrum successfully treated with astemizole.
Topics: Adult; Astemizole; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; Middle Aged; Sunlight; | 1990 |
Astemizole--another non-sedating antihistamine.
Topics: Astemizole; Benzimidazoles; Chronic Disease; Drug Administration Schedule; Histamine H1 Antagonists; | 1989 |
[Treatment of urticaria with the new H1 antihistaminic astemizole--with special reference to the time of onset of effect and maximum effect].
Topics: Adolescent; Adult; Angioedema; Astemizole; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; | 1986 |
The development of a new antihistamine: astemizole.
Topics: Administration, Oral; Animals; Astemizole; Benzimidazoles; Conjunctivitis, Allergic; Histamine H1 An | 1985 |
[General review of a non-sedative antihistaminic, astemizole (Hismanal), a H1 receptor antagonist].
Topics: Astemizole; Asthma; Benzimidazoles; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Perennial; | 1988 |
Antihistamines in the treatment of urticarial disorders.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Histamine H1 Antagonists; Humans; | 1988 |
[Experimental studies with external and internal administration of antihistaminics in insect venom allergies].
Topics: Administration, Oral; Administration, Topical; Anaphylaxis; Astemizole; Bee Venoms; Benzimidazoles; | 1988 |
[Treatment of chronic urticaria with astemizole: a multicenter pediatric study].
Topics: Adolescent; Astemizole; Benzimidazoles; Child; Child, Preschool; Chronic Disease; Cross-Sectional St | 1987 |