astemizole has been researched along with Rhinitis, Allergic, Nonseasonal in 27 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the efficacy and side effects of the H1-antihistamine astemizole in perennial rhinitis." | 9.05 | Effect of the nonsedative H1-receptor antagonist astemizole in perennial allergic and nonallergic rhinitis. ( Bresson, K; Gundersen, G; Mygind, N; Petersen, BN; Petersen, LN; Wihl, JA, 1985) |
| "We studied the efficacy and side effects of the H1-antihistamine astemizole in perennial rhinitis." | 5.05 | Effect of the nonsedative H1-receptor antagonist astemizole in perennial allergic and nonallergic rhinitis. ( Bresson, K; Gundersen, G; Mygind, N; Petersen, BN; Petersen, LN; Wihl, JA, 1985) |
| "The second-generation H1-receptor antagonists terfenadine, astemizole, loratadine, and cetirizine are important first-line drugs for the relief of symptoms in patients with allergic rhinoconjunctivitis or chronic urticaria and may eventually supplant the potentially sedating first-generation H1-receptor antagonists in the treatment of these disorders." | 4.78 | Recent advances in H1-receptor antagonist treatment. ( Simons, FE, 1990) |
| "Astemizole is a long-acting antihistamine that blocks the H1 receptors." | 3.76 | [A new H1-blocking antihistamine. Critical review of pharmacological and clinical studies]. ( Emmi, L; Rossi, O, 1988) |
| "Astemizole is a nonsedative H1-antagonist." | 2.66 | Astemizole in perennial allergic rhinitis with seasonal exacerbations: a placebo-controlled double-blind study. ( Neuman, I; Tanay, A, 1989) |
| "Astemizole was superior to placebo and the classical antihistamines like Clemastine, Terfenadine, Ketotifen, Mequitazine, pheniramine and Chlorphenamine." | 2.66 | [Total review of all results collected worldwide with astemizole (Hismanal)]. ( Rombaut, N; Vanden Bussche, G, 1985) |
| "Triamcinolone is a commonly used synthetic corticosteroid that has recently been tested in a large clinical trial for chronic obstructive pulmonary disease and shown to have some benefits." | 2.41 | Triamcinolone: new and old indications. ( Doggrell, SA, 2001) |
| " Second-generation antihistamines have become increasingly popular because of their comparable efficacy and lower incidence of adverse effects relative to their first-generation counterparts, and the safety and efficacy of this drug class are established in the adult population." | 1.35 | Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. ( Moeller, ML; Nahata, MC; Phan, H, 2009) |
| "Astemizole is a non-sedative and non-toxic drug, even during chronic use." | 1.27 | [General review of a non-sedative antihistaminic, astemizole (Hismanal), a H1 receptor antagonist]. ( Molkhou, P, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (44.44) | 18.7374 |
| 1990's | 12 (44.44) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Menciu, C | 1 |
| Duflos, M | 1 |
| Fouchard, F | 1 |
| Le Baut, G | 1 |
| Emig, P | 1 |
| Achterrath, U | 1 |
| Szelenyi, I | 1 |
| Nickel, B | 1 |
| Schmidt, J | 1 |
| Kutscher, B | 1 |
| Günther, E | 1 |
| Phan, H | 1 |
| Moeller, ML | 1 |
| Nahata, MC | 1 |
| Simons, FE | 3 |
| Watson, WT | 1 |
| Becker, AB | 1 |
| Simons, KJ | 2 |
| Day, JH | 1 |
| Briscoe, MP | 1 |
| Clark, RH | 1 |
| Ellis, AK | 1 |
| Gervais, P | 1 |
| Crawford, WW | 1 |
| Klaustermeyer, WB | 1 |
| Lee, PH | 1 |
| Placik, IM | 1 |
| Sugimoto, Y | 1 |
| Kawamoto, E | 1 |
| Chen, Z | 1 |
| Kamei, C | 1 |
| Doggrell, SA | 1 |
| Krause, HF | 1 |
| Faraj, BA | 1 |
| Jackson, RT | 1 |
| Yaniv, E | 1 |
| Oppenheim, D | 1 |
| Fuchs, C | 1 |
| Businco, L | 1 |
| Monteleone, A | 1 |
| Ruggeri, L | 1 |
| Cantani, A | 1 |
| Chevallier, P | 1 |
| Wood, SF | 1 |
| Bunnag, C | 1 |
| Jareoncharsri, P | 1 |
| Wong, EC | 1 |
| Lobaton, P | 1 |
| Moreno, F | 1 |
| Coulie, P | 1 |
| Tanay, A | 1 |
| Neuman, I | 1 |
| Rombaut, N | 2 |
| Vanden Bussche, G | 2 |
| Wihl, JA | 1 |
| Petersen, BN | 1 |
| Petersen, LN | 1 |
| Gundersen, G | 1 |
| Bresson, K | 1 |
| Mygind, N | 1 |
| Sooknundun, M | 1 |
| Kacker, SK | 1 |
| Sundaram, KR | 1 |
| Emanuel, MB | 1 |
| Ray, JA | 1 |
| Emmi, L | 1 |
| Rossi, O | 1 |
| Boland, N | 1 |
| Molkhou, P | 1 |
| Kesselman, MS | 1 |
| Giddins, NG | 1 |
| Pelech, AN | 1 |
| Sibbald, B | 1 |
| Hilton, S | 1 |
| D'Souza, M | 1 |
| Fish, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age[NCT04957927] | Phase 4 | 60 participants (Anticipated) | Interventional | 2020-12-12 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for astemizole and Rhinitis, Allergic, Nonseasonal
| Article | Year |
|---|---|
Triamcinolone: new and old indications.
Topics: Administration, Intranasal; Adult; Aerosols; Androstadienes; Anti-Inflammatory Agents; Arthritis, Rh | 2001 |
New strategies for the prevention and treatment of allergic rhinitis in children.
Topics: Allergens; Animals; Astemizole; Child; Histamine H1 Antagonists; Household Articles; Humans; Mites; | 1992 |
Clinical experience with non-sedating antihistamines in paediatric allergic rhinitis.
Topics: Adolescent; Astemizole; Asthma; Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; | 1992 |
Recent advances in H1-receptor antagonist treatment.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonis | 1990 |
[A new H1-blocking antihistamine. Critical review of pharmacological and clinical studies].
Topics: Animals; Astemizole; Benzimidazoles; Clinical Trials as Topic; Conjunctivitis, Allergic; Dogs; Doubl | 1988 |
13 trials available for astemizole and Rhinitis, Allergic, Nonseasonal
| Article | Year |
|---|---|
Histamine blockade after astemizole in children: a single-dose, placebo-controlled study.
Topics: Astemizole; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Female; Histamine Rele | 1994 |
Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis.
Topics: Adolescent; Adult; Anti-Allergic Agents; Astemizole; Cetirizine; Double-Blind Method; Environmental | 1997 |
Comparative efficacy of terfenadine, loratadine, and astemizole in perennial allergic rhinitis.
Topics: Adrenergic Agents; Allergens; Ambulatory Care; Analysis of Variance; Anti-Allergic Agents; Astemizol | 1998 |
A double-blind comparison of nasal budesonide and oral astemizole for the treatment of perennial rhinitis.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Astemizole; Budesonide; | 1992 |
Comparison of cetirizine with astemizole in the treatment of perennial allergic rhinitis and study of the concomitant effect on histamine and allergen-induced wheal responses.
Topics: Adult; Astemizole; Benzimidazoles; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Humans | 1990 |
Astemizole in perennial allergic rhinitis with seasonal exacerbations: a placebo-controlled double-blind study.
Topics: Astemizole; Benzimidazoles; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; | 1989 |
[Total review of all results collected worldwide with astemizole (Hismanal)].
Topics: Astemizole; Beclomethasone; Benzimidazoles; Bronchitis; Clinical Trials as Topic; Conjunctivitis; Do | 1985 |
Effect of the nonsedative H1-receptor antagonist astemizole in perennial allergic and nonallergic rhinitis.
Topics: Adolescent; Adult; Aged; Astemizole; Beclomethasone; Benzimidazoles; Circadian Rhythm; Clinical Tria | 1985 |
Clinical profile of astemizole. A survey of 50 double-blind trials.
Topics: Astemizole; Benzimidazoles; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; | 1987 |
[A new H1-blocking antihistamine. Critical review of pharmacological and clinical studies].
Topics: Animals; Astemizole; Benzimidazoles; Clinical Trials as Topic; Conjunctivitis, Allergic; Dogs; Doubl | 1988 |
A double-blind study of astemizole and terfenadine in the treatment of perennial rhinitis.
Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Clinical Trials as Topic | 1988 |
An open cross-over trial comparing two doses of astemizole and beclomethasone dipropionate in the treatment of perennial rhinitis.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Astemizole; Beclomethasone; Benzimidazoles; Cli | 1986 |
[Multicenter double-blind study comparing astemizole and terfenadine for nonseasonal rhinitis in the adult].
Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Double-Blind Method; Drug Tolerance; Female | 1988 |
10 other studies available for astemizole and Rhinitis, Allergic, Nonseasonal
| Article | Year |
|---|---|
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Topics: Acetylcholine; Animals; Anti-Allergic Agents; Bronchoalveolar Lavage; Capillary Permeability; Carbac | 1999 |
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.
Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Ceti | 2009 |
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Mode | 2000 |
Antihistamines and decongestants.
Topics: Astemizole; Drug Interactions; Histamine H1 Antagonists; Humans; Nasal Decongestants; Rhinitis, Alle | 1992 |
Effect of astemizole on antigen-mediated histamine release from the blood of patients with allergic rhinitis.
Topics: Adolescent; Adult; Allergens; Astemizole; Basophils; Child; Histamine Release; Humans; In Vitro Tech | 1992 |
Chronic rhinitis in children.
Topics: Age Factors; Astemizole; Bacterial Infections; Carbolines; Child; Child, Preschool; Chronic Disease; | 1992 |
Treatment of allergic rhinitis with a new long-acting H1 receptor antagonist: astemizole.
Topics: Adult; Appetite; Astemizole; Benzimidazoles; Chlorpheniramine; Drug Evaluation; Female; Histamine H1 | 1987 |
The development of a new antihistamine: astemizole.
Topics: Administration, Oral; Animals; Astemizole; Benzimidazoles; Conjunctivitis, Allergic; Histamine H1 An | 1985 |
[General review of a non-sedative antihistaminic, astemizole (Hismanal), a H1 receptor antagonist].
Topics: Astemizole; Asthma; Benzimidazoles; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Perennial; | 1988 |
Astemizole-induced torsade de pointes.
Topics: Adolescent; Astemizole; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; Rhinitis, Allergic | 1988 |