astemizole has been researched along with Pregnancy in 9 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Astemizole (ATZ), a non-sedative antihistamine, which antagonize histamine at the level of H1 receptor, was administered daily to female Wistar rats as a 10-mg/kg dose throughout pregnancy." | 3.69 | Perinatal astemizole exposure in the rat throughout gestation: long-term behavioral and anatomic effects associated with reproduction. ( Almeida, RG; Bernardi, MM; Massoco, CO; Spinosa, HS, 1996) |
| " Instead, single dosing on specific days is proposed to be a better way to characterize the teratogenic potential of Ikr blocking drugs." | 2.44 | Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. ( Danielsson, BR; Danielsson, C; Nilsson, MF, 2007) |
| " However, this activity may be missed in conventional teratology studies because repeat dosing may cause resorptions." | 1.36 | Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs. ( Bengtsson, E; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Khan, KM; Kultima, K; Nilsson, MF; Sköld, AC; Webster, WS; Wilson, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nilsson, MF | 2 |
| Danielsson, C | 2 |
| Sköld, AC | 1 |
| Johansson, A | 1 |
| Blomgren, B | 1 |
| Wilson, J | 1 |
| Khan, KM | 1 |
| Bengtsson, E | 1 |
| Kultima, K | 1 |
| Webster, WS | 1 |
| Danielsson, BR | 2 |
| Tena Alavez, G | 1 |
| Blancas Espinosa, R | 1 |
| Ruiz Medina, J | 1 |
| Almeida, RG | 1 |
| Massoco, CO | 1 |
| Spinosa, HS | 1 |
| Bernardi, MM | 1 |
| Pastuszak, A | 1 |
| Schick, B | 1 |
| D'Alimonte, D | 1 |
| Donnenfeld, A | 1 |
| Koren, G | 2 |
| Mazzotta, P | 1 |
| Kelso, JM | 1 |
| Schatz, M | 1 |
| Lantin, JP | 1 |
| Pécoud, A | 1 |
| Whyatt, PL | 1 |
1 review available for astemizole and Pregnancy
| Article | Year |
|---|---|
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 2007 |
8 other studies available for astemizole and Pregnancy
| Article | Year |
|---|---|
Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Cetirizine; Drug Evaluation, Preclinical; Embryo C | 2010 |
[Gestational herpes. Presentation of a case and review of the literature].
Topics: Adult; Astemizole; Female; Humans; Infant, Newborn; Ointments; Pemphigoid Gestationis; Postpartum Pe | 1994 |
Perinatal astemizole exposure in the rat throughout gestation: long-term behavioral and anatomic effects associated with reproduction.
Topics: Animals; Astemizole; Behavior, Animal; Female; Histamine H1 Antagonists; Male; Motor Activity; Pregn | 1996 |
The safety of astemizole in pregnancy.
Topics: Abnormalities, Multiple; Adult; Anti-Allergic Agents; Astemizole; Female; Histamine H1 Antagonists; | 1996 |
Nonsedating antihistamines in pregnancy.
Topics: Adult; Anti-Allergic Agents; Astemizole; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; | 1997 |
Astemizole use in pregnancy.
Topics: Astemizole; Asthma; Case-Control Studies; Ethics, Medical; Female; Histamine H1 Antagonists; Humans; | 1998 |
[Optimal use of antihistaminics].
Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; | 1989 |
Astemizole in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Benzimidazoles; Female; Histamine H1 Antagonists; | 1986 |