astemizole has been researched along with Long QT Syndrome in 14 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 7.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| " We compared cetirizine, another compound of that class, to D-sotalol and to astemizole in a model of acquired long QT syndrome." | 7.70 | Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. ( Cheymol, G; Jaillon, P; Noyer, M; Weissenburger, J, 1999) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 3.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| " We compared cetirizine, another compound of that class, to D-sotalol and to astemizole in a model of acquired long QT syndrome." | 3.70 | Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. ( Cheymol, G; Jaillon, P; Noyer, M; Weissenburger, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Pearlstein, R | 1 |
| Vaz, R | 1 |
| Rampe, D | 1 |
| Romero, L | 1 |
| Trenor, B | 1 |
| Yang, PC | 1 |
| Saiz, J | 1 |
| Clancy, CE | 1 |
| Dabhi, J | 1 |
| Mehta, A | 1 |
| Roy, J | 1 |
| Vantol, B | 1 |
| Cowley, EA | 1 |
| Blay, J | 1 |
| Linsdell, P | 1 |
| Conti, CR | 1 |
| Broadhurst, P | 1 |
| Nathan, AW | 1 |
| Sakemi, H | 1 |
| VanNatta, B | 1 |
| Hsieh, MH | 1 |
| Chen, SA | 1 |
| Chiang, CE | 1 |
| Tai, CT | 1 |
| Lee, SH | 1 |
| Wen, ZC | 1 |
| Chang, MS | 1 |
| Weissenburger, J | 1 |
| Noyer, M | 1 |
| Cheymol, G | 1 |
| Jaillon, P | 1 |
| Zhou, Z | 1 |
| Gong, Q | 1 |
| January, CT | 1 |
| Yamamoto, K | 1 |
| Tamura, T | 1 |
| Imai, R | 1 |
| Yamamoto, M | 1 |
| Mansfield, RJ | 1 |
| Thomas, RD | 1 |
| Ficker, E | 1 |
| Obejero-Paz, CA | 1 |
| Zhao, S | 1 |
| Brown, AM | 1 |
1 review available for astemizole and Long QT Syndrome
| Article | Year |
|---|---|
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ER | 2003 |
13 other studies available for astemizole and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.
Topics: Action Potentials; Anti-Arrhythmia Agents; Astemizole; Cisapride; Computer Simulation; Gene Expressi | 2014 |
QT prolongation and safety in the Indian population.
Topics: Astemizole; Cisapride; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Electroc | 2007 |
Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7.
Topics: Adenocarcinoma; Anti-Allergic Agents; Anti-Arrhythmia Agents; Astemizole; Breast Neoplasms; Cell Pro | 2008 |
The nonsedating antihistamine scare.
Topics: Astemizole; Drug Interactions; Drug Therapy, Combination; Humans; Long QT Syndrome; Terfenadine | 1994 |
Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion.
Topics: Adult; Astemizole; Electrocardiography; Female; Heart Arrest; Humans; Long QT Syndrome | 1993 |
Torsade de pointes induced by astemizole in a patient with prolongation of the QT interval.
Topics: Adult; Astemizole; Electrocardiography; Female; Humans; Long QT Syndrome; Torsades de Pointes | 1993 |
Drug-induced torsades de pointes in one patient with congenital long QT syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Astemizole; Cardiac Pacing, Artificial; Electr | 1996 |
Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Astemizole; Cetirizine; Dogs; Dose-Response Rela | 1999 |
Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects.
Topics: Anti-Arrhythmia Agents; Astemizole; Biological Transport; Cation Transport Proteins; Cell Compartmen | 1999 |
Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.
Topics: Acute Disease; Anesthesia; Anesthetics, Inhalation; Animals; Astemizole; Atrioventricular Node; Cath | 2001 |
Recurrent syncope. Drug induced long QT syndrome.
Topics: Adult; Anti-Allergic Agents; Antimalarials; Astemizole; Chloroquine; Electrocardiography; Humans; Lo | 2001 |
The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
Topics: Anti-Arrhythmia Agents; Astemizole; Benzimidazoles; Binding Sites; Blotting, Western; Cation Transpo | 2002 |