astemizole has been researched along with Hypersensitivity in 18 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Astemizole was superior to placebo and the classical antihistamines like Clemastine, Terfenadine, Ketotifen, Mequitazine, pheniramine and Chlorphenamine." | 2.66 | [Total review of all results collected worldwide with astemizole (Hismanal)]. ( Rombaut, N; Vanden Bussche, G, 1985) |
| "Astemizole is an H1-histamine receptor antagonist with a long duration of action permitting once daily administration." | 2.37 | Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy. ( Avery, GS; Brogden, RN; Heel, RC; Richards, DM; Speight, TM, 1984) |
| " In numerous tests no evidence of central activity was found and toxicity studies have shown astemizole to be a very safe drug despite of its long duration of action." | 1.27 | The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole. ( Awouters, F; Janssen, PA; Niemegeers, CJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Menciu, C | 1 |
| Duflos, M | 1 |
| Fouchard, F | 1 |
| Le Baut, G | 1 |
| Emig, P | 1 |
| Achterrath, U | 1 |
| Szelenyi, I | 1 |
| Nickel, B | 1 |
| Schmidt, J | 1 |
| Kutscher, B | 1 |
| Günther, E | 1 |
| CASTELAIN, PY | 1 |
| BESSON, J | 1 |
| BENDA, R | 1 |
| ORINSTEIN, E | 1 |
| MIRAVET, LF | 1 |
| Awouters, FH | 1 |
| Niemegeers, CJ | 2 |
| Janssen, PA | 2 |
| Richards, DM | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Mazzotta, P | 1 |
| Koren, G | 1 |
| Lane, HY | 1 |
| Chang, WH | 1 |
| Chou, JC | 1 |
| Ryhal, BT | 1 |
| Fletcher, MP | 1 |
| Kamei, C | 1 |
| Mio, M | 1 |
| Izushi, K | 1 |
| Kitazumi, K | 1 |
| Tsujimoto, S | 1 |
| Fujisawa, K | 1 |
| Adachi, Y | 1 |
| Tasaka, K | 1 |
| Chand, N | 2 |
| Pillar, J | 1 |
| Diamantis, W | 2 |
| Sofia, RD | 2 |
| Lantin, JP | 1 |
| Pécoud, A | 2 |
| Rombaut, N | 1 |
| Vanden Bussche, G | 1 |
| Karrass, W | 1 |
| Brandon, ML | 1 |
| Awouters, F | 1 |
| Harrison, JE | 1 |
| Rooney, SM | 1 |
2 reviews available for astemizole and Hypersensitivity
| Article | Year |
|---|---|
Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy.
Topics: Animals; Astemizole; Benzimidazoles; Conjunctivitis; Dermatitis, Contact; Histamine H1 Antagonists; | 1984 |
The second-generation antihistamines. What makes them different?
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Brain; Cetirizine; Cyprohepta | 1991 |
2 trials available for astemizole and Hypersensitivity
| Article | Year |
|---|---|
[Total review of all results collected worldwide with astemizole (Hismanal)].
Topics: Astemizole; Beclomethasone; Benzimidazoles; Bronchitis; Clinical Trials as Topic; Conjunctivitis; Do | 1985 |
[Hismanal--a non-sedating H1 antihistaminic].
Topics: Arousal; Astemizole; Automobile Driving; Benzimidazoles; Brain; Clinical Trials as Topic; Dose-Respo | 1985 |
14 other studies available for astemizole and Hypersensitivity
| Article | Year |
|---|---|
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Topics: Acetylcholine; Animals; Anti-Allergic Agents; Bronchoalveolar Lavage; Capillary Permeability; Carbac | 1999 |
[Clinical study of the effects of human gamma globulin with high histamino protective power in 69 cases of allergic diseases].
Topics: Astemizole; gamma-Globulins; Globulins; Hypersensitivity; Immune System Diseases | 1960 |
[Histamino-protective (or histaminophylactic) capacity of certain human serums. Application to the study of asthma and various allergic syndromes].
Topics: Astemizole; Asthma; Humans; Hypersensitivity; Immune System Diseases; Syndrome | 1959 |
Pharmacology of the specific histamine H1-antagonist astemizole.
Topics: Animals; Astemizole; Benzimidazoles; Dogs; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity; | 1983 |
Nonsedating antihistamines in pregnancy.
Topics: Adult; Anti-Allergic Agents; Astemizole; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; | 1997 |
Seizure during risperidone treatment in an elderly woman treated with concomitant medications.
Topics: Age Factors; Aged; Antipsychotic Agents; Astemizole; Comorbidity; Dose-Response Relationship, Drug; | 1998 |
Antiallergic effects of major metabolites of astemizole in rats and guinea pigs.
Topics: Animals; Astemizole; Binding, Competitive; Bronchoconstriction; Cerebellum; Guinea Pigs; Heart Rate; | 1991 |
Inhibition of IgE-mediated allergic histamine release from rat peritoneal mast cells by azelastine and selected antiallergic drugs.
Topics: Animals; Astemizole; Benzimidazoles; Diphenhydramine; Histamine Release; Hypersensitivity; Immunoglo | 1985 |
[Optimal use of antihistaminics].
Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; | 1989 |
[Allergy treatment--10 years' results using astemizole. Proceedings of the International Hismanal Symposium. Garmisch-Partenkirchen, 24-26 February 1989. Abstracts].
Topics: Astemizole; Benzimidazoles; Histamine H1 Antagonists; Humans; Hypersensitivity | 1989 |
Newer non-sedating antihistamines. Will they replace older agents?
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Humans; Hypersensitivity | 1985 |
The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole.
Topics: Anaphylaxis; Animals; Astemizole; Benzimidazoles; Histamine H1 Antagonists; Hypersensitivity; p-Meth | 1986 |
[A new generation of H1-receptor antagonist antihistaminics].
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Hypersensitivity; Phenot | 1986 |
Inhibition of passive cutaneous anaphylaxis (PCA) by azelastine: dissociation of its antiallergic activities from antihistaminic and antiserotonin properties.
Topics: Animals; Antigens; Astemizole; Benzimidazoles; Histamine Antagonists; Hypersensitivity; Ketotifen; M | 1985 |