astemizole has been researched along with Drug Overdose in 13 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Astemizole, a relatively new H1 blocker, has been reported to cause ventricular arrhythmias in the poisoned patient." | 8.79 | Arrhythmias after astemizole overdose. ( Heidemann, SM; Sarnaik, AP, 1996) |
| "The possible occurrence of torsade de pointes in astemizole overdose, and the long elimination time of astemizole and hydroxylated metabolites, makes it necessary to maintain ECG monitoring until QT interval has returned to normal." | 5.29 | Prolonged QT interval and torsade de pointes following astemizole overdose. ( Danel, V; Dixmerias, F; Saviuc, P, 1993) |
| "Astemizole (Hismanal-Janssen, New Brunswick, NJ) is a nonsedating antihistamine that has the advantage of a once-daily dosage schedule." | 5.29 | Torsade de pointes associated with Astemizole overdose treated with magnesium sulfate. ( Hasan, RA; Nolan, BM; Zureikat, GY, 1993) |
| "Astemizole, a relatively new H1 blocker, has been reported to cause ventricular arrhythmias in the poisoned patient." | 4.79 | Arrhythmias after astemizole overdose. ( Heidemann, SM; Sarnaik, AP, 1996) |
| " We report a case in which a deliberate overdose of astemizole was associated with Mobitz type two heart block and prolongation of the QT interval, causing the so-called torsade-de-pointes ventricular tachycardia." | 3.68 | Astemizole-induced ventricular arrhythmias: an unexpected cause of convulsions. ( Clark, A; Love, H, 1991) |
| "Treatment of astemizole-induced torsades de pointes includes discontinuing use of astemizole, intravenous administration of magnesium sulfate and isoproterenol, temporary cardiac pacing, and, when necessary, direct current cardioversion." | 2.39 | Torsades de pointes ventricular tachycardia associated with overdose of astemizole. ( Adlakha, A; Meloy, TD; Rao, KA; Stanton, MS; Verma-Ansil, B, 1994) |
| "The possible occurrence of torsade de pointes in astemizole overdose, and the long elimination time of astemizole and hydroxylated metabolites, makes it necessary to maintain ECG monitoring until QT interval has returned to normal." | 1.29 | Prolonged QT interval and torsade de pointes following astemizole overdose. ( Danel, V; Dixmerias, F; Saviuc, P, 1993) |
| "Astemizole (Hismanal-Janssen, New Brunswick, NJ) is a nonsedating antihistamine that has the advantage of a once-daily dosage schedule." | 1.29 | Torsade de pointes associated with Astemizole overdose treated with magnesium sulfate. ( Hasan, RA; Nolan, BM; Zureikat, GY, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kelloway, JS | 1 |
| Pongowski, MA | 1 |
| Schoenwetter, WF | 1 |
| Henretig, FM | 2 |
| Rao, KA | 1 |
| Adlakha, A | 1 |
| Verma-Ansil, B | 1 |
| Meloy, TD | 1 |
| Stanton, MS | 1 |
| Wiley, JF | 1 |
| Honig, PK | 1 |
| Sevka, MJ | 1 |
| Saviuc, P | 1 |
| Danel, V | 1 |
| Dixmerias, F | 1 |
| Burke, TG | 1 |
| Mutnick, AH | 1 |
| Hasan, RA | 1 |
| Zureikat, GY | 1 |
| Nolan, BM | 1 |
| Heidemann, SM | 1 |
| Sarnaik, AP | 1 |
| Mack, RB | 1 |
| Leor, J | 1 |
| Harman, M | 1 |
| Rabinowitz, B | 1 |
| Mozes, B | 1 |
| Clark, A | 1 |
| Love, H | 1 |
| Tobin, JR | 1 |
| Doyle, TP | 1 |
| Ackerman, AD | 1 |
| Brenner, JI | 1 |
4 reviews available for astemizole and Drug Overdose
| Article | Year |
|---|---|
Special considerations in the poisoned pediatric patient.
Topics: Acetaminophen; Alcoholic Intoxication; Astemizole; Child; Child, Preschool; Clonidine; Cocaine; Crit | 1994 |
Torsades de pointes ventricular tachycardia associated with overdose of astemizole.
Topics: Adult; Astemizole; Drug Overdose; Electrocardiography; Female; Humans; Rhinitis, Vasomotor; Torsades | 1994 |
Ventricular fibrillation and anoxic encephalopathy secondary to astemizole overdose.
Topics: Adult; Astemizole; Brain Diseases; Drug Overdose; Female; Humans; Hypoxia, Brain; Resuscitation; Ven | 1993 |
Arrhythmias after astemizole overdose.
Topics: Adolescent; Arrhythmias, Cardiac; Astemizole; Drug Overdose; Female; Histamine H1 Antagonists; Human | 1996 |
9 other studies available for astemizole and Drug Overdose
| Article | Year |
|---|---|
Additional causes of torsades de pointes.
Topics: Astemizole; Drug Overdose; Humans; Terfenadine; Torsades de Pointes | 1995 |
Torsade de pointes.
Topics: Adolescent; Astemizole; Drug Overdose; Humans; Magnesium Sulfate; Torsades de Pointes | 1993 |
Comment: ventricular fibrillation and anoxic encephalopathy secondary to astemizole overdose.
Topics: Astemizole; Drug Overdose; Female; Humans; Hypoxia, Brain; Ventricular Fibrillation | 1993 |
Prolonged QT interval and torsade de pointes following astemizole overdose.
Topics: Adult; Astemizole; Drug Overdose; Electrocardiography; Female; Gastric Lavage; Half-Life; Humans; Is | 1993 |
Torsade de pointes associated with Astemizole overdose treated with magnesium sulfate.
Topics: Adolescent; Astemizole; Drug Overdose; Electrocardiography; Female; Humans; Magnesium Sulfate; Poiso | 1993 |
Was Hercules a stable person? Astemizole overdose.
Topics: Age Factors; Arrhythmias, Cardiac; Astemizole; Child, Preschool; Dose-Response Relationship, Drug; D | 1992 |
Giant U waves and associated ventricular tachycardia complicating astemizole overdose: successful therapy with intravenous magnesium.
Topics: Adult; Astemizole; Benzimidazoles; Drug Overdose; Electrocardiography; Histamine H1 Antagonists; Hum | 1991 |
Astemizole-induced ventricular arrhythmias: an unexpected cause of convulsions.
Topics: Adolescent; Astemizole; Drug Overdose; Electrocardiography; Female; Heart Block; Humans; Seizures; T | 1991 |
Astemizole-induced cardiac conduction disturbances in a child.
Topics: Arrhythmias, Cardiac; Astemizole; Drug Overdose; Electrocardiography; Female; Heart Conduction Syste | 1991 |