astemizole has been researched along with Disease Models, Animal in 15 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since astemizole in an oral dose of 50 mg/kg/day was recently reported to exert anti-cancer effect in mice, we evaluated its proarrhythmic potential using the atrioventricular block dogs in order to clarify its cardiac safety profile." | 7.83 | Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Nakamura, Y; Sugiyama, A; Wada, T, 2016) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 7.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| "In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model." | 7.69 | Effects of astemizole on ventricular activation delay and RT intervals in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, Y; Nakashima, M; Nishimoto, M; Ohashi, K; Ohmura, T; Umemura, K; Watanabe, S, 1997) |
| "Since astemizole in an oral dose of 50 mg/kg/day was recently reported to exert anti-cancer effect in mice, we evaluated its proarrhythmic potential using the atrioventricular block dogs in order to clarify its cardiac safety profile." | 3.83 | Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Nakamura, Y; Sugiyama, A; Wada, T, 2016) |
| "Effects of tecastemizole were assessed in a murine model of allergic lung inflammation, in passive cutaneous anaphylaxis (PCA) responses in guinea-pig skin and in in vitro assays measuring endothelial adhesion molecule expression and leucocyte-endothelial adhesion." | 3.74 | Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. ( Hefni, A; Lever, R; Moffatt, JD; Page, CP; Paul, W, 2007) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 3.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| "In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model." | 3.69 | Effects of astemizole on ventricular activation delay and RT intervals in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, Y; Nakashima, M; Nishimoto, M; Ohashi, K; Ohmura, T; Umemura, K; Watanabe, S, 1997) |
| "Parkinson's disease is a growing threat to an ever-ageing population." | 1.46 | Validating the Predicted Effect of Astemizole and Ketoconazole Using a Drosophila Model of Parkinson's Disease. ( Styczyńska-Soczka, K; Zechini, L; Zografos, L, 2017) |
| "These data support the view that hyperalgesia induced by the magnesium-depleted diet is not a consequence of the inflammatory process." | 1.31 | Assessment of the relationship between hyperalgesia and peripheral inflammation in magnesium-deficient rats. ( Alloui, A; Begon, S; Dubray, C; Eschalier, A; Mazur, A; Rayssiguier, Y, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 5 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chong, CR | 1 |
| Chen, X | 1 |
| Shi, L | 1 |
| Liu, JO | 1 |
| Sullivan, DJ | 1 |
| Musonda, CC | 1 |
| Whitlock, GA | 1 |
| Witty, MJ | 1 |
| Brun, R | 1 |
| Kaiser, M | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Mambwe, D | 2 |
| Korkor, CM | 2 |
| Mabhula, A | 2 |
| Ngqumba, Z | 2 |
| Cloete, C | 2 |
| Kumar, M | 2 |
| Barros, PL | 2 |
| Leshabane, M | 2 |
| Coertzen, D | 2 |
| Taylor, D | 2 |
| Gibhard, L | 2 |
| Njoroge, M | 2 |
| Lawrence, N | 2 |
| Reader, J | 2 |
| Moreira, DR | 2 |
| Birkholtz, LM | 2 |
| Wittlin, S | 2 |
| Egan, TJ | 2 |
| Chibale, K | 2 |
| Styczyńska-Soczka, K | 1 |
| Zechini, L | 1 |
| Zografos, L | 1 |
| Izumi-Nakaseko, H | 1 |
| Nakamura, Y | 1 |
| Cao, X | 1 |
| Wada, T | 1 |
| Ando, K | 1 |
| Sugiyama, A | 1 |
| Vu, K | 1 |
| Gelli, A | 1 |
| Lever, R | 1 |
| Hefni, A | 1 |
| Moffatt, JD | 1 |
| Paul, W | 1 |
| Page, CP | 1 |
| Nishimoto, M | 1 |
| Hashimoto, H | 1 |
| Ohmura, T | 1 |
| Ikeda, Y | 1 |
| Watanabe, S | 1 |
| Ohashi, K | 1 |
| Umemura, K | 1 |
| Nakashima, M | 1 |
| Sugimoto, Y | 1 |
| Kawamoto, E | 1 |
| Chen, Z | 1 |
| Kamei, C | 1 |
| Yamamoto, K | 1 |
| Tamura, T | 1 |
| Imai, R | 1 |
| Yamamoto, M | 1 |
| Begon, S | 1 |
| Alloui, A | 1 |
| Eschalier, A | 1 |
| Mazur, A | 1 |
| Rayssiguier, Y | 1 |
| Dubray, C | 1 |
| Kim, MB | 1 |
| Lee, Y | 1 |
| Bae, M | 1 |
| Kang, H | 1 |
| Hu, S | 1 |
| Pham, TX | 1 |
| Lee, JY | 1 |
| Park, YK | 1 |
| Han, HJ | 1 |
| Park, SK | 1 |
| Kang, JY | 1 |
| Kim, JM | 1 |
| Yoo, SK | 1 |
| Kim, DO | 1 |
| Kim, GH | 1 |
| Heo, HJ | 1 |
| Woo, H | 1 |
| Kim, MK | 1 |
| Park, S | 1 |
| Han, SH | 1 |
| Shin, HC | 1 |
| Kim, BG | 1 |
| Oh, SH | 1 |
| Suh, MW | 1 |
| Lee, JH | 1 |
| Park, MK | 1 |
15 other studies available for astemizole and Disease Models, Animal
| Article | Year |
|---|---|
A clinical drug library screen identifies astemizole as an antimalarial agent.
Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Dose-Response Relationship, | 2006 |
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity.
Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinica | 2009 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and
Topics: Animals; Antimalarials; Astemizole; Disease Models, Animal; Malaria; Mice; Plasmodium berghei; Plasm | 2022 |
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and
Topics: Animals; Antimalarials; Astemizole; Disease Models, Animal; Malaria; Mice; Plasmodium berghei; Plasm | 2022 |
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and
Topics: Animals; Antimalarials; Astemizole; Disease Models, Animal; Malaria; Mice; Plasmodium berghei; Plasm | 2022 |
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and
Topics: Animals; Antimalarials; Astemizole; Disease Models, Animal; Malaria; Mice; Plasmodium berghei; Plasm | 2022 |
Validating the Predicted Effect of Astemizole and Ketoconazole Using a Drosophila Model of Parkinson's Disease.
Topics: Animals; Astemizole; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Drug Repo | 2017 |
Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model.
Topics: Animals; Antineoplastic Agents; Astemizole; Atrioventricular Block; Disease Models, Animal; Dogs; Fe | 2016 |
Astemizole and an analogue promote fungicidal activity of fluconazole against Cryptococcus neoformans var. grubii and Cryptococcus gattii.
Topics: Animals; Antifungal Agents; Astemizole; Cryptococcosis; Cryptococcus gattii; Cryptococcus neoformans | 2010 |
Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Astemizole; Benzimidazoles; Cell Adhesion; Cell Adhe | 2007 |
Effects of astemizole on ventricular activation delay and RT intervals in a canine myocardial infarction model.
Topics: Animals; Arrhythmias, Cardiac; Astemizole; Blood Pressure; Disease Models, Animal; Dogs; Dose-Respon | 1997 |
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Mode | 2000 |
Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.
Topics: Acute Disease; Anesthesia; Anesthetics, Inhalation; Animals; Astemizole; Atrioventricular Node; Cath | 2001 |
Assessment of the relationship between hyperalgesia and peripheral inflammation in magnesium-deficient rats.
Topics: Animals; Anti-Inflammatory Agents; Astemizole; Cimetidine; Cromolyn Sodium; Dexamethasone; Disease M | 2002 |
Sugar kelp (Saccharina latissima) inhibits hepatic inflammation and fibrosis in a mouse model of diet-induced nonalcoholic steatohepatitis.
Topics: Adipose Tissue, White; Animals; Diet; Diet, High-Fat; Disease Models, Animal; Energy Metabolism; Hep | 2021 |
Mixture of Phlorotannin and Fucoidan from
Topics: Acetylcholine; Animals; Aquatic Organisms; Brain; Cholinergic Agents; Cognitive Dysfunction; Disease | 2021 |
Effect of Phlorofucofuroeckol A and Dieckol Extracted from
Topics: Animals; Antioxidants; Aquatic Organisms; Benzofurans; Cochlea; Dioxins; Disease Models, Animal; Evo | 2021 |