astemizole has been researched along with Diabetic Retinopathy in 2 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of astemizole, an antihistamine, versus placebo on the 1-year course of diabetic macular edema (DME) and to illustrate use of a modified ETDRS system for grading areas of retinal thickening and hard exudates that may be useful in clinical trials of treatments for this disorder." | 9.12 | An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy Trial. ( Blankenship, GW; Brod, RD; Davis, MD; Gardner, TW; Hubbard, L; Kunselman, A; Larsen, ML; Lund-Andersen, H; Parving, HH; Post-Hansen, H; Quillen, DA; Reimers, J; Sander, B; Tenhave, T; Wilmarth, MH, 2006) |
| "To compare the effects of astemizole, an antihistamine, versus placebo on the 1-year course of diabetic macular edema (DME) and to illustrate use of a modified ETDRS system for grading areas of retinal thickening and hard exudates that may be useful in clinical trials of treatments for this disorder." | 5.12 | An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy Trial. ( Blankenship, GW; Brod, RD; Davis, MD; Gardner, TW; Hubbard, L; Kunselman, A; Larsen, ML; Lund-Andersen, H; Parving, HH; Post-Hansen, H; Quillen, DA; Reimers, J; Sander, B; Tenhave, T; Wilmarth, MH, 2006) |
| "Fourteen patients with type I (insulin-dependent) diabetes and mild nonproliferative diabetic retinopathy were treated with combined astemizole, 20 mg, and ranitidine, 600 mg, or an identical placebo for 6 months in a double-masked fashion." | 5.08 | Antihistamines reduce blood-retinal barrier permeability in type I (insulin-dependent) diabetic patients with nonproliferative retinopathy. A pilot study. ( D'Antonio, JA; Eller, AW; Friberg, TR; Gardner, TW; Hollis, TM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gardner, TW | 2 |
| Sander, B | 1 |
| Larsen, ML | 1 |
| Kunselman, A | 1 |
| Tenhave, T | 1 |
| Lund-Andersen, H | 1 |
| Reimers, J | 1 |
| Hubbard, L | 1 |
| Blankenship, GW | 1 |
| Quillen, DA | 1 |
| Brod, RD | 1 |
| Wilmarth, MH | 1 |
| Post-Hansen, H | 1 |
| Parving, HH | 1 |
| Davis, MD | 1 |
| Eller, AW | 1 |
| Friberg, TR | 1 |
| D'Antonio, JA | 1 |
| Hollis, TM | 1 |
2 trials available for astemizole and Diabetic Retinopathy
| Article | Year |
|---|---|
An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy Trial.
Topics: Adult; Astemizole; Blood-Retinal Barrier; Diabetic Retinopathy; Diagnostic Techniques, Ophthalmologi | 2006 |
Antihistamines reduce blood-retinal barrier permeability in type I (insulin-dependent) diabetic patients with nonproliferative retinopathy. A pilot study.
Topics: Adult; Astemizole; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Type 1; Diabeti | 1995 |