astemizole has been researched along with Chronic Disease in 18 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind clinical trial of 51 patients with chronic idiopathic urticaria using oral astemizole for 8 weeks demonstrated significant improvement in symptoms and lesions in 75% of treated patients versus 20% in the placebo group." | 9.06 | Prolonged benefit in the treatment of chronic idiopathic urticaria with astemizole. ( Honsinger, RW; Thomsen, RJ, 1990) |
| "Forty patients with chronic urticaria were treated with terfenadine or astemizole in a randomized double-blind study." | 9.06 | Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients. ( Bödeker, RH; Paul, E, 1989) |
| "Astemizole is a new, long-acting H1 receptor antagonist that has proven effective in controlling the signs and symptoms of chronic idiopathic urticaria, without the sedative and anticholinergic side effects that typify use of many antihistamines." | 9.06 | Treatment of chronic idiopathic urticaria with astemizole. ( Bergfeld, WF; Dijkstra, JW; Huerter, CJ; Wagner, WO, 1989) |
| "Astemizole, one of the newer generation of nonsedating antihistamines, was evaluated in a double-blind study of forty-six patients who had chronic idiopathic urticaria with or without angioedema; most had severe disease." | 9.06 | Controlled clinical assessment of astemizole in the treatment of chronic idiopathic urticaria and angioedema. ( Kailasam, V; Mathews, KP, 1987) |
| "Two new non-sedating antihistamines, astemizole (10 mg per day) and terfenadine (120 mg per day), were compared in a double-blind randomized study in 42 adult patients suffering from chronic urticaria." | 9.06 | Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria. ( Cainelli, T; Mosca, M; Seidenari, S; Valsecchi, R, 1986) |
| "The efficacy and safety of astemizole (AST), a new long-acting H1 antagonist with minimal sedative or anticholinergic side effects, were studied in an 8-week double-blind trial of 51 patients with chronic idiopathic urticaria." | 9.06 | Efficacy and safety of astemizole, a long-acting and nonsedating H1 antagonist for the treatment of chronic idiopathic urticaria. ( Bernstein, DI; Bernstein, IL, 1986) |
| "Thirty-eight patients with chronic vertigo and positional and/or spontaneous nystagmus finished a double-blind study to determine the efficacy of astemizole on nystagmus and its symptoms." | 9.06 | Astemizole. Its use in the treatment of patients with chronic vertigo. ( Jackson, RT; Turner, JS, 1987) |
| "40 patients suffering from chronic urticaria were randomly treated with either Terfenadine or Astemizole." | 9.05 | [Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients]. ( Bödeker, RH; Paul, E, 1985) |
| "An open multicentric pediatric clinical trial has been performed to evaluate the safety and efficacy of astemizole (HISMANAL suspension) at a 1 ml (2 mg) dosage per 10 kg body weight once daily in children with chronic urticaria." | 7.67 | [Treatment of chronic urticaria with astemizole: a multicenter pediatric study]. ( Guinnepain, MT, 1987) |
| "Treatment with astemizole, as measured at the end point of each patient's treatment and compared to placebo, resulted in significant improvement of pruritus, erythema, number of wheals, frequency of urticarial attacks, and control of urticaria (p less than or equal to 0." | 6.66 | The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials. ( Bukantz, SC; Fox, RW; Lockey, RF; Serbousek, D, 1986) |
| "The efficacy of astemizole, diphenhydramine, and hydroxyzine hydrochloride in the treatment of chronic idiopathic urticaria was evaluated in this 3-month double-blind, randomized, parallel group study." | 5.07 | Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria. ( Jancelewicz, Z; Sussman, G, 1991) |
| "A double-blind clinical trial of 51 patients with chronic idiopathic urticaria using oral astemizole for 8 weeks demonstrated significant improvement in symptoms and lesions in 75% of treated patients versus 20% in the placebo group." | 5.06 | Prolonged benefit in the treatment of chronic idiopathic urticaria with astemizole. ( Honsinger, RW; Thomsen, RJ, 1990) |
| "Forty patients with chronic urticaria were treated with terfenadine or astemizole in a randomized double-blind study." | 5.06 | Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients. ( Bödeker, RH; Paul, E, 1989) |
| "Astemizole is a new, long-acting H1 receptor antagonist that has proven effective in controlling the signs and symptoms of chronic idiopathic urticaria, without the sedative and anticholinergic side effects that typify use of many antihistamines." | 5.06 | Treatment of chronic idiopathic urticaria with astemizole. ( Bergfeld, WF; Dijkstra, JW; Huerter, CJ; Wagner, WO, 1989) |
| "Astemizole, one of the newer generation of nonsedating antihistamines, was evaluated in a double-blind study of forty-six patients who had chronic idiopathic urticaria with or without angioedema; most had severe disease." | 5.06 | Controlled clinical assessment of astemizole in the treatment of chronic idiopathic urticaria and angioedema. ( Kailasam, V; Mathews, KP, 1987) |
| "Two new non-sedating antihistamines, astemizole (10 mg per day) and terfenadine (120 mg per day), were compared in a double-blind randomized study in 42 adult patients suffering from chronic urticaria." | 5.06 | Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria. ( Cainelli, T; Mosca, M; Seidenari, S; Valsecchi, R, 1986) |
| "The efficacy and safety of astemizole (AST), a new long-acting H1 antagonist with minimal sedative or anticholinergic side effects, were studied in an 8-week double-blind trial of 51 patients with chronic idiopathic urticaria." | 5.06 | Efficacy and safety of astemizole, a long-acting and nonsedating H1 antagonist for the treatment of chronic idiopathic urticaria. ( Bernstein, DI; Bernstein, IL, 1986) |
| "Thirty-eight patients with chronic vertigo and positional and/or spontaneous nystagmus finished a double-blind study to determine the efficacy of astemizole on nystagmus and its symptoms." | 5.06 | Astemizole. Its use in the treatment of patients with chronic vertigo. ( Jackson, RT; Turner, JS, 1987) |
| "40 patients suffering from chronic urticaria were randomly treated with either Terfenadine or Astemizole." | 5.05 | [Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients]. ( Bödeker, RH; Paul, E, 1985) |
| "An open multicentric pediatric clinical trial has been performed to evaluate the safety and efficacy of astemizole (HISMANAL suspension) at a 1 ml (2 mg) dosage per 10 kg body weight once daily in children with chronic urticaria." | 3.67 | [Treatment of chronic urticaria with astemizole: a multicenter pediatric study]. ( Guinnepain, MT, 1987) |
| "Treatment with astemizole, as measured at the end point of each patient's treatment and compared to placebo, resulted in significant improvement of pruritus, erythema, number of wheals, frequency of urticarial attacks, and control of urticaria (p less than or equal to 0." | 2.66 | The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials. ( Bukantz, SC; Fox, RW; Lockey, RF; Serbousek, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (83.33) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turner, JS | 2 |
| Jackson, RT | 2 |
| Krause, LB | 1 |
| Shuster, S | 2 |
| Yaniv, E | 1 |
| Oppenheim, D | 1 |
| Fuchs, C | 1 |
| Sussman, G | 1 |
| Jancelewicz, Z | 1 |
| Honsinger, RW | 1 |
| Thomsen, RJ | 1 |
| Paul, E | 2 |
| Bödeker, RH | 2 |
| Huerter, CJ | 1 |
| Bergfeld, WF | 1 |
| Wagner, WO | 1 |
| Dijkstra, JW | 1 |
| Kailasam, V | 1 |
| Mathews, KP | 1 |
| Cainelli, T | 1 |
| Seidenari, S | 1 |
| Valsecchi, R | 1 |
| Mosca, M | 1 |
| Bernstein, IL | 1 |
| Bernstein, DI | 1 |
| Fox, RW | 1 |
| Lockey, RF | 1 |
| Bukantz, SC | 1 |
| Serbousek, D | 1 |
| De Castro-Costa, M | 1 |
| Gybels, J | 1 |
| Kupers, R | 1 |
| Van Hees, J | 1 |
| Wexler, DB | 1 |
| Guinnepain, MT | 1 |
11 trials available for astemizole and Chronic Disease
| Article | Year |
|---|---|
H1-receptor-active histamine not sole cause of chronic idiopathic urticaria.
Topics: Astemizole; Benzimidazoles; Chronic Disease; Histamine; Histamine H1 Antagonists; Humans; Urticaria | 1984 |
Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria.
Topics: Adult; Aged; Astemizole; Chronic Disease; Diphenhydramine; Dose-Response Relationship, Drug; Double- | 1991 |
Prolonged benefit in the treatment of chronic idiopathic urticaria with astemizole.
Topics: Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Histamin | 1990 |
Comparative study of astemizole and terfenadine in the treatment of chronic idiopathic urticaria. A randomized double-blind study of 40 patients.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double- | 1989 |
Treatment of chronic idiopathic urticaria with astemizole.
Topics: Adolescent; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Female; Histamine | 1989 |
[Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients].
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double- | 1985 |
Controlled clinical assessment of astemizole in the treatment of chronic idiopathic urticaria and angioedema.
Topics: Adult; Angioedema; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Double-Bli | 1987 |
Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria.
Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Double-Blind M | 1986 |
Efficacy and safety of astemizole, a long-acting and nonsedating H1 antagonist for the treatment of chronic idiopathic urticaria.
Topics: Adult; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Consumer Behavior; Dou | 1986 |
The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials.
Topics: Adolescent; Adult; Aged; Astemizole; Benzimidazoles; Chronic Disease; Clinical Trials as Topic; Doub | 1986 |
Astemizole. Its use in the treatment of patients with chronic vertigo.
Topics: Adult; Aged; Astemizole; Benzimidazoles; Chronic Disease; Consumer Behavior; Dizziness; Double-Blind | 1987 |
7 other studies available for astemizole and Chronic Disease
| Article | Year |
|---|---|
Astemizole: its use in patients with chronic vertigo and eng signs--a pilot study of a new drug.
Topics: Adult; Astemizole; Benzimidazoles; Chronic Disease; Electronystagmography; Female; Histamine H1 Anta | 1983 |
Chronic rhinitis in children.
Topics: Age Factors; Astemizole; Bacterial Infections; Carbolines; Child; Child, Preschool; Chronic Disease; | 1992 |
Astemizole--another non-sedating antihistamine.
Topics: Astemizole; Benzimidazoles; Chronic Disease; Drug Administration Schedule; Histamine H1 Antagonists; | 1989 |
Antihistamines in the treatment of urticarial disorders.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Chronic Disease; Histamine H1 Antagonists; Humans; | 1988 |
Scratching behaviour in arthritic rats: a sign of chronic pain or itch?
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Astemizole; Behavior, Animal; Benzimidazoles; | 1987 |
Astemizole for treatment of chronic vertigo.
Topics: Astemizole; Benzimidazoles; Chronic Disease; Humans; Research Design; Vertigo | 1987 |
[Treatment of chronic urticaria with astemizole: a multicenter pediatric study].
Topics: Adolescent; Astemizole; Benzimidazoles; Child; Child, Preschool; Chronic Disease; Cross-Sectional St | 1987 |