astemizole has been researched along with Breast Cancer in 9 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to study the potential cooperative antiproliferative effect of the EGFR inhibitor gefitinib and the EAG1-blocker astemizole, in breast cancer cells." | 7.91 | ASTEMIZOLE, AN INHIBITOR OF ETHER-À-GO-GO-1 POTASSIUM CHANNEL, INCREASES THE ACTIVITY OF THE TYROSINE KINASE INHIBITOR GEFITINIB IN BREAST CANCER CELLS. ( Díaz, L; García-Becerra, R; García-Quiroz, J; González-González, ME; Larrea, F; Ordaz-Rosado, D; Prado-García, H; Segovia-Mendoza, M, 2019) |
| " Since astemizole improves calcitriol bioavailability and activity, decreased calcitriol dosing is advised for conjoint administration." | 5.38 | Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy. ( Avila, E; Barrera, D; Camacho, J; Díaz, L; Gamboa-Domínguez, A; García-Becerra, R; García-Quiroz, J; Halhali, A; Larrea, F; Medina-Franco, H; Ordaz-Rosado, D; Rivas-Suárez, M; Rodríguez, P; Santos, N, 2012) |
| "We aimed to study the potential cooperative antiproliferative effect of the EGFR inhibitor gefitinib and the EAG1-blocker astemizole, in breast cancer cells." | 3.91 | ASTEMIZOLE, AN INHIBITOR OF ETHER-À-GO-GO-1 POTASSIUM CHANNEL, INCREASES THE ACTIVITY OF THE TYROSINE KINASE INHIBITOR GEFITINIB IN BREAST CANCER CELLS. ( Díaz, L; García-Becerra, R; García-Quiroz, J; González-González, ME; Larrea, F; Ordaz-Rosado, D; Prado-García, H; Segovia-Mendoza, M, 2019) |
| "In the present study, exposure of MCF-7 breast cancer cells to HIS and the H1 receptor antagonist AST both alone and together with HIS (AST-HIS) led to generation of intracellular ROS, which induced massive cellular vacuolization through dilation of the ER and mitochondria." | 1.43 | Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis. ( Bhardwaj, M; Jakhar, R; Kang, SC; Paul, S, 2016) |
| " Since astemizole improves calcitriol bioavailability and activity, decreased calcitriol dosing is advised for conjoint administration." | 1.38 | Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy. ( Avila, E; Barrera, D; Camacho, J; Díaz, L; Gamboa-Domínguez, A; García-Becerra, R; García-Quiroz, J; Halhali, A; Larrea, F; Medina-Franco, H; Ordaz-Rosado, D; Rivas-Suárez, M; Rodríguez, P; Santos, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Germain, AR | 1 |
| Carmody, LC | 1 |
| Nag, PP | 1 |
| Morgan, B | 1 |
| Verplank, L | 1 |
| Fernandez, C | 1 |
| Donckele, E | 1 |
| Feng, Y | 1 |
| Perez, JR | 1 |
| Dandapani, S | 1 |
| Palmer, M | 1 |
| Lander, ES | 1 |
| Gupta, PB | 1 |
| Schreiber, SL | 1 |
| Munoz, B | 1 |
| García-Quiroz, J | 3 |
| González-González, ME | 1 |
| Díaz, L | 3 |
| Ordaz-Rosado, D | 3 |
| Segovia-Mendoza, M | 1 |
| Prado-García, H | 1 |
| Larrea, F | 3 |
| García-Becerra, R | 3 |
| Santos-Martínez, N | 1 |
| Barrera, D | 2 |
| Avila, E | 2 |
| Halhali, A | 2 |
| Villanueva, O | 1 |
| Ibarra-Sánchez, MJ | 1 |
| Esparza-López, J | 1 |
| Gamboa-Domínguez, A | 2 |
| Camacho, J | 2 |
| Jakhar, R | 1 |
| Paul, S | 1 |
| Bhardwaj, M | 1 |
| Kang, SC | 1 |
| Santos, N | 1 |
| Rivas-Suárez, M | 1 |
| Rodríguez, P | 1 |
| Medina-Franco, H | 1 |
| Borowiec, AS | 1 |
| Hague, F | 1 |
| Harir, N | 1 |
| Guénin, S | 1 |
| Guerineau, F | 1 |
| Gouilleux, F | 1 |
| Roudbaraki, M | 2 |
| Lassoued, K | 1 |
| Ouadid-Ahidouch, H | 2 |
| Roy, J | 1 |
| Vantol, B | 1 |
| Cowley, EA | 1 |
| Blay, J | 1 |
| Linsdell, P | 1 |
| Gudi, R | 1 |
| Krishnamurthy, M | 1 |
| Pachter, BR | 1 |
| Le Bourhis, X | 1 |
| Toillon, RA | 1 |
| Delcourt, P | 1 |
| Prevarskaya, N | 1 |
9 other studies available for astemizole and Breast Cancer
| Article | Year |
|---|---|
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neopla | 2013 |
ASTEMIZOLE, AN INHIBITOR OF ETHER-À-GO-GO-1 POTASSIUM CHANNEL, INCREASES THE ACTIVITY OF THE TYROSINE KINASE INHIBITOR GEFITINIB IN BREAST CANCER CELLS.
Topics: Antineoplastic Agents; Astemizole; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Resp | 2019 |
In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astemizole; Breast N | 2014 |
Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apo | 2016 |
Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy.
Topics: Antineoplastic Agents; Astemizole; Blotting, Western; Breast Neoplasms; Calcitriol; Calcium Channel | 2012 |
IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.
Topics: Androstadienes; Astemizole; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Ether-A-Go-Go Po | 2007 |
Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7.
Topics: Adenocarcinoma; Anti-Allergic Agents; Anti-Arrhythmia Agents; Astemizole; Breast Neoplasms; Cell Pro | 2008 |
Astemizole in the treatment of granulocyte colony-stimulating factor-induced bone pain.
Topics: Astemizole; Bone and Bones; Breast Neoplasms; Female; Granulocyte Colony-Stimulating Factor; Humans; | 1995 |
Changes in the K+ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h-ether.a-gogo K+ channel.
Topics: Astemizole; Biological Transport; Breast Neoplasms; Cell Cycle; Electric Conductivity; Ether-A-Go-Go | 2001 |