astemizole has been researched along with Atopic Hypersensitivity in 11 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of astemizole on the weal and flare response to intradermal histamine has been studied in normal volunteers after single dosing, and in patients with urticaria and pruritus after chronic dosing with the drug." | 3.66 | The effects of astemizole on histamine-induced weal and flare. ( Bateman, DN; Chapman, PH; Rawlins, MD, 1983) |
| "Erythromycin was started to treat presumed bacterial infection in children with complete radiologic opacification of the maxillary sinus(es)." | 2.69 | Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children. ( Delgado, LF; Naspitz, CK; Pferferman, A; Solé, D, 1998) |
| " As expected, astemizole-D tended to have a longer duration of action, with symptom severity lower with this agent than with loratadine-D during the second challenge session despite the differences in dosing schedule." | 2.68 | Efficacy and tolerability of astemizole-D and Loratadine-D during prolonged, controlled allergen challenge in the Vienna Challenge Chamber. ( Berger, U; Horak, F; Jäger, S; Toth, J, 1996) |
| "Astemizole is a very effective inhibitor of allergic reactions in rats and dogs." | 1.27 | [Pharmacology of astemizole (Hismanal) a non-sedating H1 antihistaminic]. ( Niemegeers, CJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bateman, DN | 1 |
| Chapman, PH | 1 |
| Rawlins, MD | 1 |
| Janssens, MM | 1 |
| Horak, F | 2 |
| Toth, J | 2 |
| Jäger, S | 2 |
| Berger, U | 2 |
| Delgado, LF | 1 |
| Pferferman, A | 1 |
| Solé, D | 1 |
| Naspitz, CK | 1 |
| Klausner, MA | 1 |
| Kaliner, MA | 1 |
| Bierman, CW | 1 |
| Maxwell, D | 1 |
| Rytina, E | 1 |
| Emanuel, MB | 1 |
| Lee, TH | 1 |
| Tasaka, K | 1 |
| Akagi, M | 1 |
| Izushi, K | 1 |
| Mio, M | 1 |
| Niemegeers, CJ | 1 |
| Gendreau-Reid, L | 1 |
| Simons, KJ | 1 |
| Simons, FE | 1 |
2 reviews available for astemizole and Atopic Hypersensitivity
| Article | Year |
|---|---|
Astemizole. A nonsedating antihistamine with fast and sustained activity.
Topics: Astemizole; Child; Humans; Hypersensitivity, Immediate; Nasal Provocation Tests; Psychomotor Perform | 1993 |
Nonsedating antihistamines: pharmacology, clinical efficacy and adverse effects.
Topics: Astemizole; Cyproheptadine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadin | 1992 |
5 trials available for astemizole and Atopic Hypersensitivity
| Article | Year |
|---|---|
Effects of H1-receptor antagonists on nasal obstruction in atopic patients.
Topics: Adult; Airway Resistance; Allergens; Astemizole; Diagnosis, Computer-Assisted; Double-Blind Method; | 1993 |
Efficacy and tolerability of astemizole-D and Loratadine-D during prolonged, controlled allergen challenge in the Vienna Challenge Chamber.
Topics: Adult; Airway Resistance; Anti-Allergic Agents; Astemizole; Bronchial Provocation Tests; Cross-Over | 1996 |
Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children.
Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Astemizole; Cetirizine; Child; Child, Preschool; Drug I | 1998 |
Effect of H1-receptor blockade on late cutaneous reactions to antigen: a double-blind, controlled study.
Topics: Antigens; Astemizole; Benzimidazoles; Biopsy; Double-Blind Method; Eosinophils; Histamine H1 Antagon | 1991 |
Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on histamine-induced wheals and flares in humans.
Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Dose-Response Relationship, Immunologic; Do | 1986 |
4 other studies available for astemizole and Atopic Hypersensitivity
| Article | Year |
|---|---|
The effects of astemizole on histamine-induced weal and flare.
Topics: Adult; Aged; Astemizole; Benzimidazoles; Drug Hypersensitivity; Drug Interactions; Female; Histamine | 1983 |
Astemizole use with erythromycin.
Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Astemizole; Child; Contraindications; Drug Interactions | 1999 |
Antiallergic effects of astemizole on immediate type hypersensitivity reactions.
Topics: Airway Resistance; Animals; Astemizole; Asthma; Benzimidazoles; Calcium; Guinea Pigs; Histamine H1 A | 1990 |
[Pharmacology of astemizole (Hismanal) a non-sedating H1 antihistaminic].
Topics: Administration, Oral; Anaphylaxis; Animals; Arousal; Astemizole; Benzimidazoles; Cerebellum; Dose-Re | 1985 |