astemizole has been researched along with Asthma in 15 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a placebo-controlled, double-blind, crossover study with a washout phase of 2 months between each treatment period, single daily doses of 10 and 30 mg of astemizole were given to 12 patients with extrinsic asthma during 28 consecutive days." | 9.07 | Effect of astemizole on allergic asthma. ( Abadías, M; Cisteró, A; Jané, F; Lafuente, V; Lleonart, R; Pintó, E; Torrent, J, 1992) |
| "Astemizole, administered for seven days to asthmatic subjects, had an effect of bronchoconstriction induced by inhaled histamine for a mean period of 42 days." | 9.07 | Single-dose effect of astemizole on bronchoconstriction induced by histamine in asthmatic subjects. ( Benoît, C; Cartier, A; Ghezzo, H; Malo, JL, 1992) |
| "The ability of the new generation H1-receptor antagonist, astemizole, to prevent histamine-induced airway obstruction and exercise-induced asthma (EIA) was studied in 20 children with asthma." | 9.06 | The effect of astemizole on bronchial hyperresponsiveness and exercise-induced asthma in children. ( Bach-Mortensen, N; Backer, V; Becker, U; Brink, L; Hansen, KK; Howitz, P; Jensen, DW; Laursen, EM, 1989) |
| "Astemizole, a new oral long acting antihistamine devoid of significant central, sedative or anticholinergic effects, was studied in nine patients with exercise-induced asthma." | 9.05 | The effect of astemizole on exercise-induced asthma. ( Clee, MD; Ingram, CG; Reid, PC; Robertson, AS, 1984) |
| "The disparity between the activation of mast cells in the airways of patients with allergic asthma and the lack of efficacy of H1-antihistamines in asthma therapy has been difficult to reconcile." | 7.67 | Astemizole and other H1-antihistaminic drug treatment of asthma. ( Emanuel, MB; Holgate, ST; Howarth, PH, 1985) |
| "In a placebo-controlled, double-blind, crossover study with a washout phase of 2 months between each treatment period, single daily doses of 10 and 30 mg of astemizole were given to 12 patients with extrinsic asthma during 28 consecutive days." | 5.07 | Effect of astemizole on allergic asthma. ( Abadías, M; Cisteró, A; Jané, F; Lafuente, V; Lleonart, R; Pintó, E; Torrent, J, 1992) |
| "Astemizole, administered for seven days to asthmatic subjects, had an effect of bronchoconstriction induced by inhaled histamine for a mean period of 42 days." | 5.07 | Single-dose effect of astemizole on bronchoconstriction induced by histamine in asthmatic subjects. ( Benoît, C; Cartier, A; Ghezzo, H; Malo, JL, 1992) |
| " To investigate the possibility that benzalkonium chloride-induced bronchoconstriction results from the endogenous release of histamine, we examined the effect of the selective histamine antagonists terfenadine and astemizole, on the airways response to inhaled benzalkonium chloride and histamine in 12 asthmatic subjects." | 5.06 | The contribution of histamine release to bronchoconstriction provoked by inhaled benzalkonium chloride in asthma. ( Beasley, R; Holgate, ST; Miszkiel, KA; Rafferty, P, 1988) |
| "The ability of the new generation H1-receptor antagonist, astemizole, to prevent histamine-induced airway obstruction and exercise-induced asthma (EIA) was studied in 20 children with asthma." | 5.06 | The effect of astemizole on bronchial hyperresponsiveness and exercise-induced asthma in children. ( Bach-Mortensen, N; Backer, V; Becker, U; Brink, L; Hansen, KK; Howitz, P; Jensen, DW; Laursen, EM, 1989) |
| "Astemizole, a new oral long acting antihistamine devoid of significant central, sedative or anticholinergic effects, was studied in nine patients with exercise-induced asthma." | 5.05 | The effect of astemizole on exercise-induced asthma. ( Clee, MD; Ingram, CG; Reid, PC; Robertson, AS, 1984) |
| "The disparity between the activation of mast cells in the airways of patients with allergic asthma and the lack of efficacy of H1-antihistamines in asthma therapy has been difficult to reconcile." | 3.67 | Astemizole and other H1-antihistaminic drug treatment of asthma. ( Emanuel, MB; Holgate, ST; Howarth, PH, 1985) |
| "PC20 histamine was assessed on the 3 consecutive days before starting the trial, on the last day of medication, 3 days later, and once a week thereafter until PC20 returned to baseline." | 2.67 | Duration of the effect of astemizole on histamine-inhalation tests. ( Cartier, A; Fu, CL; Ghezzo, H; L'Archevêque, J; Malo, JL, 1990) |
| "Triamcinolone is a commonly used synthetic corticosteroid that has recently been tested in a large clinical trial for chronic obstructive pulmonary disease and shown to have some benefits." | 2.41 | Triamcinolone: new and old indications. ( Doggrell, SA, 2001) |
| "Astemizole is a non-sedative and non-toxic drug, even during chronic use." | 1.27 | [General review of a non-sedative antihistaminic, astemizole (Hismanal), a H1 receptor antagonist]. ( Molkhou, P, 1988) |
| " The cumulative results indicate that the nonsedative antihistamine terfenadine, given orally at a dosage of 60 mg twice daily, is effective in the treatment of seasonal allergic rhinitis in both adults and children." | 1.27 | The use of antihistamines for the treatment of airway disease. ( Meltzer, EO, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BENDA, R | 1 |
| ORINSTEIN, E | 1 |
| MIRAVET, LF | 1 |
| Clee, MD | 1 |
| Ingram, CG | 1 |
| Reid, PC | 1 |
| Robertson, AS | 1 |
| Kelso, JM | 1 |
| Schatz, M | 1 |
| Doggrell, SA | 1 |
| Wood, SF | 1 |
| Cisteró, A | 1 |
| Abadías, M | 1 |
| Lleonart, R | 1 |
| Lafuente, V | 1 |
| Pintó, E | 1 |
| Torrent, J | 1 |
| Jané, F | 1 |
| Benoît, C | 1 |
| Malo, JL | 2 |
| Ghezzo, H | 2 |
| Cartier, A | 2 |
| Tasaka, K | 1 |
| Akagi, M | 1 |
| Izushi, K | 1 |
| Mio, M | 1 |
| Fu, CL | 1 |
| L'Archevêque, J | 1 |
| Miszkiel, KA | 1 |
| Beasley, R | 1 |
| Rafferty, P | 1 |
| Holgate, ST | 2 |
| Backer, V | 1 |
| Bach-Mortensen, N | 1 |
| Becker, U | 1 |
| Brink, L | 1 |
| Howitz, P | 1 |
| Hansen, KK | 1 |
| Jensen, DW | 1 |
| Laursen, EM | 1 |
| Lantin, JP | 1 |
| Pécoud, A | 1 |
| Emanuel, MB | 1 |
| Howarth, PH | 1 |
| Molkhou, P | 1 |
| Meltzer, EO | 1 |
2 reviews available for astemizole and Asthma
| Article | Year |
|---|---|
Triamcinolone: new and old indications.
Topics: Administration, Intranasal; Adult; Aerosols; Androstadienes; Anti-Inflammatory Agents; Arthritis, Rh | 2001 |
Clinical experience with non-sedating antihistamines in paediatric allergic rhinitis.
Topics: Adolescent; Astemizole; Asthma; Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; | 1992 |
6 trials available for astemizole and Asthma
| Article | Year |
|---|---|
The effect of astemizole on exercise-induced asthma.
Topics: Adult; Astemizole; Asthma; Asthma, Exercise-Induced; Benzimidazoles; Clinical Trials as Topic; Femal | 1984 |
Effect of astemizole on allergic asthma.
Topics: Adolescent; Adult; Albuterol; Astemizole; Asthma; Bronchial Provocation Tests; Double-Blind Method; | 1992 |
Single-dose effect of astemizole on bronchoconstriction induced by histamine in asthmatic subjects.
Topics: Adult; Aged; Astemizole; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Meth | 1992 |
Duration of the effect of astemizole on histamine-inhalation tests.
Topics: Administration, Inhalation; Adult; Aged; Astemizole; Asthma; Benzimidazoles; Bronchial Provocation T | 1990 |
The contribution of histamine release to bronchoconstriction provoked by inhaled benzalkonium chloride in asthma.
Topics: Adult; Astemizole; Asthma; Benzalkonium Compounds; Benzhydryl Compounds; Benzimidazoles; Bronchial P | 1988 |
The effect of astemizole on bronchial hyperresponsiveness and exercise-induced asthma in children.
Topics: Administration, Oral; Adolescent; Astemizole; Asthma; Asthma, Exercise-Induced; Benzimidazoles; Bron | 1989 |
7 other studies available for astemizole and Asthma
| Article | Year |
|---|---|
[Histamino-protective (or histaminophylactic) capacity of certain human serums. Application to the study of asthma and various allergic syndromes].
Topics: Astemizole; Asthma; Humans; Hypersensitivity; Immune System Diseases; Syndrome | 1959 |
Astemizole use in pregnancy.
Topics: Astemizole; Asthma; Case-Control Studies; Ethics, Medical; Female; Histamine H1 Antagonists; Humans; | 1998 |
Antiallergic effects of astemizole on immediate type hypersensitivity reactions.
Topics: Airway Resistance; Animals; Astemizole; Asthma; Benzimidazoles; Calcium; Guinea Pigs; Histamine H1 A | 1990 |
[Optimal use of antihistaminics].
Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; | 1989 |
Astemizole and other H1-antihistaminic drug treatment of asthma.
Topics: Astemizole; Asthma; Benzimidazoles; Bronchial Provocation Tests; Bronchial Spasm; Histamine; Histami | 1985 |
[General review of a non-sedative antihistaminic, astemizole (Hismanal), a H1 receptor antagonist].
Topics: Astemizole; Asthma; Benzimidazoles; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Perennial; | 1988 |
The use of antihistamines for the treatment of airway disease.
Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Child; Chlorpheniramine; Double-Blind Meth | 1988 |