Compounds > astemizole
Page last updated: 2024-10-23

astemizole and Arrhythmia

astemizole has been researched along with Arrhythmia in 29 studies

Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.

Research Excerpts

ExcerptRelevanceReference
"Astemizole, a relatively new H1 blocker, has been reported to cause ventricular arrhythmias in the poisoned patient."8.79Arrhythmias after astemizole overdose. ( Heidemann, SM; Sarnaik, AP, 1996)
"To clarify the mechanisms of enhanced cardiotoxic effects of astemizole in ischemic hearts, we examined the effects of astemizole on ventricular activation, effective refractory periods (ERPs), RT intervals, and incidence of programmed electrical stimulation (PES)-induced ventricular arrhythmias in the dog heart after myocardial infarction."7.70Effects of astemizole on ventricular activation, effective refractory periods, RT intervals, and programmed stimulation-induced ventricular arrhythmias in dog hearts with myocardial infarction. ( Hashimoto, H; Ikeda, Y; Nakamura, R; Nakashima, M; Nishimoto, M; Ohmura, T; Umemura, K; Watanabe, S, 1998)
"In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model."7.69Effects of astemizole on ventricular activation delay and RT intervals in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, Y; Nakashima, M; Nishimoto, M; Ohashi, K; Ohmura, T; Umemura, K; Watanabe, S, 1997)
"Although the new second-generation nonsedative antihistamines terfenadine and astemizole were launched as highly selective and specific H(1)-receptor antagonists, they were later found to cause prolongation of the QT-interval and severe cardiac arrhythmias."4.81Cardiotoxicity of new antihistamines and cisapride. ( Paakkari, I, 2002)
"Astemizole, a relatively new H1 blocker, has been reported to cause ventricular arrhythmias in the poisoned patient."4.79Arrhythmias after astemizole overdose. ( Heidemann, SM; Sarnaik, AP, 1996)
"To clarify the mechanisms of enhanced cardiotoxic effects of astemizole in ischemic hearts, we examined the effects of astemizole on ventricular activation, effective refractory periods (ERPs), RT intervals, and incidence of programmed electrical stimulation (PES)-induced ventricular arrhythmias in the dog heart after myocardial infarction."3.70Effects of astemizole on ventricular activation, effective refractory periods, RT intervals, and programmed stimulation-induced ventricular arrhythmias in dog hearts with myocardial infarction. ( Hashimoto, H; Ikeda, Y; Nakamura, R; Nakashima, M; Nishimoto, M; Ohmura, T; Umemura, K; Watanabe, S, 1998)
"Astemizole is a potent histamine H1-antagonist that has been associated with cases of life-threatening cardiac arrhythmias, including torsade de pointes and atrioventricular (AV) block."3.69Electrophysiological and arrhythmogenic effects of the histamine type 1-receptor antagonist astemizole on rabbit Purkinje fibers: clinical relevance. ( Adamantidis, MM; Caron, JF; Dupuis, BA; Lacroix, DL, 1995)
"Terfenadine and astemizole are widely prescribed nonsedating antihistamines that have been associated with QT-interval prolongation and ventricular arrhythmias."3.69Regulation of potassium channels by nonsedating antihistamines. ( Berul, CI; Morad, M, 1995)
"Concurrent use of terfenadine or astemizole with erythromycin or ketoconazole can prolong the QT interval and produce potentially fatal ventricular arrhythmias."3.69Possible interactions with terfenadine or astemizole. ( Eiselt-Proteau, D; Haxby, D; Hedges, JR; Zechnich, AD, 1994)
"In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model."3.69Effects of astemizole on ventricular activation delay and RT intervals in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, Y; Nakashima, M; Nishimoto, M; Ohashi, K; Ohmura, T; Umemura, K; Watanabe, S, 1997)
"6 cases of accidental astemizole poisoning in children have been reported to the Finnish Poison Information Center."3.68Accidental astemizole overdose in young children. ( Hoppu, K; Kouvalainen, K; Remes, M; Saarenpää-Heikkilä, O; Tapanainen, P; Tikanoja, T, 1991)
" Instead, single dosing on specific days is proposed to be a better way to characterize the teratogenic potential of Ikr blocking drugs."2.44Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. ( Danielsson, BR; Danielsson, C; Nilsson, MF, 2007)
"Astemizole was released in 1988."1.29Use of astemizole in a large group practice. ( Craig, J; Craig, TJ; Greenwald, M; Kauffmann, V, 1996)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's23 (79.31)18.2507
2000's4 (13.79)29.6817
2010's1 (3.45)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Jia, L1
Sun, H1
Brinkwirth, N1
Takasuna, K1
Doi, M1
Becker, N1
Obergrussberger, A1
Friis, S1
Furukawa, H1
Hasegawa, Y1
Oka, T1
Ohtsuki, A1
Fertig, N1
Stoelzle-Feix, S1
Watanabe, H1
Honda, Y1
Deguchi, J1
Yamada, T1
Bando, K1
Danielsson, BR1
Danielsson, C1
Nilsson, MF1
Adamantidis, MM1
Lacroix, DL1
Caron, JF1
Dupuis, BA1
Berul, CI1
Morad, M1
Zechnich, AD2
Hedges, JR1
Eiselt-Proteau, D1
Haxby, D1
Honig, PK2
Cantilena, LR1
Cohen, MR1
Davis, NM1
Gowardman, J1
Craig, TJ1
Greenwald, M1
Kauffmann, V1
Craig, J1
Haxby, DG1
Heidemann, SM1
Sarnaik, AP1
Clark, S1
Himmel, MH1
Worobec, AS1
Nishimoto, M2
Hashimoto, H2
Ohmura, T3
Ikeda, Y2
Watanabe, S2
Ohashi, K1
Umemura, K2
Nakashima, M2
Nakamura, R1
de Abajo, FJ1
Rodríguez, LA1
Gottlieb, S1
Chachin, M1
Tarui, S1
Nagakura, A1
Igarashi, T1
Ikeda, H1
Ikegami, K1
Kitagawa, H1
Uchida, S1
Gilbert, JD1
Cahill, SA1
McCartney, DG1
Lukas, A1
Gross, GJ1
Paakkari, I1
Tikanoja, T2
Hoppu, K2
Kouvalainen, K2
Mack, RB1
Wiley, JF1
Gelber, ML1
Henretig, FM1
Wiley, CC1
Sandhu, S1
Loiselle, J1
Tapanainen, P1
Remes, M1
Saarenpää-Heikkilä, O1
Tobin, JR1
Doyle, TP1
Ackerman, AD1
Brenner, JI1

Reviews

3 reviews available for astemizole and Arrhythmia

ArticleYear
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
    Reproductive toxicology (Elmsford, N.Y.), 2007, Volume: 24, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac;

2007
Arrhythmias after astemizole overdose.
    Pediatric emergency care, 1996, Volume: 12, Issue:2

    Topics: Adolescent; Arrhythmias, Cardiac; Astemizole; Drug Overdose; Female; Histamine H1 Antagonists; Human

1996
Cardiotoxicity of new antihistamines and cisapride.
    Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3

    Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Disea

2002

Other Studies

26 other studies available for astemizole and Arrhythmia

ArticleYear
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant

2008
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment.
    Journal of pharmacological and toxicological methods, 2020, Volume: 105

    Topics: Animals; Arrhythmias, Cardiac; Astemizole; Benchmarking; Calibration; Cardiovascular Agents; Cell Li

2020
Usefulness of cardiotoxicity assessment using calcium transient in human induced pluripotent stem cell-derived cardiomyocytes.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:4

    Topics: Arrhythmias, Cardiac; Astemizole; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cell Differ

2017
Electrophysiological and arrhythmogenic effects of the histamine type 1-receptor antagonist astemizole on rabbit Purkinje fibers: clinical relevance.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:2

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Astemizole; Dose-Response Relationship, Drug; Hist

1995
Regulation of potassium channels by nonsedating antihistamines.
    Circulation, 1995, Apr-15, Volume: 91, Issue:8

    Topics: Animals; Arrhythmias, Cardiac; Astemizole; Cells, Cultured; Dose-Response Relationship, Drug; Electr

1995
Possible interactions with terfenadine or astemizole.
    The Western journal of medicine, 1994, Volume: 160, Issue:4

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Child; Drug Interactions; Drug Prescripti

1994
Ketoconazole and fluconazole drug interactions.
    Archives of internal medicine, 1994, May-09, Volume: 154, Issue:9

    Topics: Antifungal Agents; Arrhythmias, Cardiac; Astemizole; Drug Interactions; Fluconazole; Humans; Ketocon

1994
Errors caused by medical office personnel.
    American pharmacy, 1993, Volume: NS33, Issue:7

    Topics: Arrhythmias, Cardiac; Astemizole; Communication; Drug Prescriptions; Humans; Medication Errors; Offi

1993
QT prolongation on the standard dose of astemizole.
    The New Zealand medical journal, 1996, Feb-09, Volume: 109, Issue:1015

    Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Astemizole; Electrocardiography; Female; Histamine H1

1996
Use of astemizole in a large group practice.
    The Journal of the American Osteopathic Association, 1996, Volume: 96, Issue:6

    Topics: Arrhythmias, Cardiac; Astemizole; Contraindications; Drug Utilization; Group Practice; Histamine H1

1996
Drug interactions associated with terfenadine and related nonsedating antihistamines.
    The Western journal of medicine, 1996, Volume: 164, Issue:1

    Topics: Arrhythmias, Cardiac; Astemizole; Drug Interactions; Histamine H1 Antagonists; Humans; Terfenadine

1996
Dangers of non-sedating antihistamines.
    Lancet (London, England), 1997, May-03, Volume: 349, Issue:9061

    Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legi

1997
Dangers of non-sedating antihistamines.
    Lancet (London, England), 1997, Jul-05, Volume: 350, Issue:9070

    Topics: Adverse Drug Reaction Reporting Systems; Arrhythmias, Cardiac; Astemizole; Histamine H1 Antagonists;

1997
Effects of astemizole on ventricular activation delay and RT intervals in a canine myocardial infarction model.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:9

    Topics: Animals; Arrhythmias, Cardiac; Astemizole; Blood Pressure; Disease Models, Animal; Dogs; Dose-Respon

1997
Effects of astemizole on ventricular activation, effective refractory periods, RT intervals, and programmed stimulation-induced ventricular arrhythmias in dog hearts with myocardial infarction.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Astemizole; Dogs; Dose-Response Relationship, Drug; Electrocardiograp

1998
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.
    British journal of clinical pharmacology, 1999, Volume: 47, Issue:3

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child;

1999
Antihistamine drug withdrawn by manufacturer.
    BMJ (Clinical research ed.), 1999, Jul-03, Volume: 319, Issue:7201

    Topics: Arrhythmias, Cardiac; Astemizole; Drug and Narcotic Control; Drug Industry; Histamine H1 Antagonists

1999
Effects of terfenadine, astemizole and epinastine on electrocardiogram in conscious cynomolgus monkeys.
    European journal of pharmacology, 1999, Aug-06, Volume: 378, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Astemizole; Dibenzazepines; Electrocardiography; Heart Block; Histami

1999
Predictors of torsades de pointes in rabbit ventricles perfused with sedating and nonsedating histamine H1-receptor antagonists.
    Canadian journal of physiology and pharmacology, 2000, Volume: 78, Issue:5

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Astemizole; Cetirizine; Electrocardiography; Heart

2000
[Risk of arrhythmia in long-acting H1-selective antihistaminics poisoning].
    Duodecim; laaketieteellinen aikakauskirja, 1992, Volume: 108, Issue:19

    Topics: Adolescent; Arrhythmias, Cardiac; Astemizole; Child; Child, Preschool; Electrocardiography; Female;

1992
Special drug communication teleconference. August 7, 1992.
    Ear, nose, & throat journal, 1992, Volume: 71, Issue:9

    Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Astemizole; Contraindications; Drug Incompatibility; Dr

1992
Was Hercules a stable person? Astemizole overdose.
    North Carolina medical journal, 1992, Volume: 53, Issue:10

    Topics: Age Factors; Arrhythmias, Cardiac; Astemizole; Child, Preschool; Dose-Response Relationship, Drug; D

1992
Cardiotoxic effects of astemizole overdose in children.
    The Journal of pediatrics, 1992, Volume: 120, Issue:5

    Topics: Arrhythmias, Cardiac; Astemizole; Child; Child, Preschool; Electrocardiography; Heart Block; Humans;

1992
Accidental astemizole overdose in young children.
    Lancet (London, England), 1991, Aug-31, Volume: 338, Issue:8766

    Topics: Accidents, Home; Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Charcoal; Child, Preschool; Combi

1991
Safety of terfenadine and astemizole.
    The Medical letter on drugs and therapeutics, 1992, Feb-07, Volume: 34, Issue:863

    Topics: Arrhythmias, Cardiac; Astemizole; Humans; Terfenadine

1992
Astemizole-induced cardiac conduction disturbances in a child.
    JAMA, 1991, Nov-20, Volume: 266, Issue:19

    Topics: Arrhythmias, Cardiac; Astemizole; Drug Overdose; Electrocardiography; Female; Heart Conduction Syste

1991