astemizole has been researched along with Abnormalities, Drug-Induced in 3 studies
Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Instead, single dosing on specific days is proposed to be a better way to characterize the teratogenic potential of Ikr blocking drugs." | 2.44 | Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. ( Danielsson, BR; Danielsson, C; Nilsson, MF, 2007) |
| " However, this activity may be missed in conventional teratology studies because repeat dosing may cause resorptions." | 1.36 | Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs. ( Bengtsson, E; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Khan, KM; Kultima, K; Nilsson, MF; Sköld, AC; Webster, WS; Wilson, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nilsson, MF | 2 |
| Danielsson, C | 2 |
| Sköld, AC | 1 |
| Johansson, A | 1 |
| Blomgren, B | 1 |
| Wilson, J | 1 |
| Khan, KM | 1 |
| Bengtsson, E | 1 |
| Kultima, K | 1 |
| Webster, WS | 1 |
| Danielsson, BR | 2 |
| Whyatt, PL | 1 |
1 review available for astemizole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 2007 |
2 other studies available for astemizole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Cetirizine; Drug Evaluation, Preclinical; Embryo C | 2010 |
Astemizole in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Benzimidazoles; Female; Histamine H1 Antagonists; | 1986 |