astaxanthine and Ventricular-Dysfunction--Left

Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxanthin supplementation. Oxidative stress markers-serum Diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations, LV ejection fraction (LVEF), and 6-min walk distance (6MWD) were assessed before and after 3-month astaxanthin supplementation. Finally, the data of 16 HF patients were analyzed. Following 3-month astaxanthin supplementation, dROM level decreased from 385.6 ± 82.6 U.CARR to 346.5 ± 56.9 U.CARR (

Topics: Aged; Antioxidants; Dietary Supplements; Exercise Tolerance; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Contraction; Oxidative Stress; Pilot Projects; Prospective Studies; Stroke Volume; Ventricular Dysfunction, Left; Ventricular Function, Left; Xanthophylls