astaxanthine and Glioma

astaxanthine has been researched along with Glioma* in 1 studies

Other Studies

1 other study(ies) available for astaxanthine and Glioma

ArticleYear
Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin.
    Marine drugs, 2019, Mar-23, Volume: 17, Issue:3

    Stress, protein aggregation, and loss of functional properties of cells have been shown to contribute to several deleterious pathologies including cancer and neurodegeneration. The incidence of these pathologies has also been shown to increase with age and are often presented as evidence to the cumulative effect of stress and protein aggregation. Prevention or delay of onset of these diseases may prove to be unprecedentedly beneficial. In this study, we explored the anti-stress and differentiation-inducing potential of two marine bioactive carotenoids (astaxanthin and fucoxanthin) using rat glioma cells as a model. We found that the low (nontoxic) doses of both protected cells against UV-induced DNA damage, heavy metal, and heat-induced protein misfolding and aggregation of proteins. Their long-term treatment in glioma cells caused the induction of physiological differentiation into astrocytes. These phenotypes were supported by upregulation of proteins that regulate cell proliferation, DNA damage repair mechanism, and glial differentiation, suggesting their potential for prevention and treatment of stress, protein aggregation, and age-related pathologies.

    Topics: Animals; Antioxidants; Cell Differentiation; Cell Line, Tumor; Cell Survival; DNA Damage; Glioma; Inhibitory Concentration 50; Protein Aggregates; Protein Aggregation, Pathological; Rats; Stress, Physiological; Ultraviolet Rays; Xanthophylls

2019