astatine and Body-Weight

Tissue factor (TF), the trigger protein of the extrinsic blood coagulation cascade, is abundantly expressed in various cancers including gastric cancer. Anti-TF monoclonal antibodies (mAbs) capable of targeting cancers have been successfully applied to armed antibodies such as antibody-drug conjugates (ADCs) and molecular imaging probes. We prepared an anti-TF mAb, clone 1084, labeled with astatine-211 (

Topics: Animals; Antibodies, Monoclonal, Humanized; Ascorbic Acid; Astatine; Blood Coagulation; Body Weight; Cell Line, Tumor; Female; Heterografts; Humans; Immunoconjugates; Linear Energy Transfer; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Denaturation; Radiation-Protective Agents; Radioimmunotherapy; Receptor, ErbB-2; Stomach Neoplasms; Thromboplastin

The goal of this study was to investigate whether targeted α-therapy can be used to successfully treat macrotumors, in addition to its established role for treating micrometastatic and minimal disease. We used an intravenous fractionated regimen of α-radioimmunotherapy in a subcutaneous tumor model in mice. We aimed to evaluate the absorbed dose levels required for tumor eradication and growth monitoring, as well as to evaluate long-term survival after treatment.

Topics: Alpha Particles; Animals; Antibodies, Monoclonal; Astatine; Body Weight; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Radiation Dosage; Radioimmunotherapy; Radiometry; Survival Analysis; Time Factors; Tissue Distribution

Topics: Androgens; Animals; Astatine; Body Weight; Castration; Estrogens; Female; Hyperplasia; Hypertrophy; Leydig Cell Tumor; Male; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Neoplasm Transplantation; Organ Size; Ovary; Pituitary Gland; Prostate; Rats; Seminal Vesicles; Testicular Neoplasms; Uterus; Vagina